The Brain's Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample
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The Brain's Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample. / Stringaris, Argyris; Vidal-Ribas Belil, Pablo; Artiges, Eric; Lemaitre, Hervé; Gollier-Briant, Fanny; Wolke, Selina; Vulser, Hélène; Miranda, Ruben; Penttilä, Jani; Struve, Maren; Fadai, Tahmine; Kappel, Viola; Grimmer, Yvonne; Goodman, Robert; Poustka, Luise; Conrod, Patricia; Cattrell, Anna; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Nees, Frauke; Papadopoulos, Dimitri; Paus, Tomas; Smolka, Michael N; Walter, Henrik; Whelan, Rob; Martinot, Jean-Luc; Schumann, Gunter; Paillère-Martinot, Marie-Laure; IMAGEN Consortium.
In: AM J PSYCHIAT, Vol. 172, No. 12, 12.2015, p. 1215-23.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The Brain's Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample
AU - Stringaris, Argyris
AU - Vidal-Ribas Belil, Pablo
AU - Artiges, Eric
AU - Lemaitre, Hervé
AU - Gollier-Briant, Fanny
AU - Wolke, Selina
AU - Vulser, Hélène
AU - Miranda, Ruben
AU - Penttilä, Jani
AU - Struve, Maren
AU - Fadai, Tahmine
AU - Kappel, Viola
AU - Grimmer, Yvonne
AU - Goodman, Robert
AU - Poustka, Luise
AU - Conrod, Patricia
AU - Cattrell, Anna
AU - Banaschewski, Tobias
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Flor, Herta
AU - Frouin, Vincent
AU - Gallinat, Jürgen
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Nees, Frauke
AU - Papadopoulos, Dimitri
AU - Paus, Tomas
AU - Smolka, Michael N
AU - Walter, Henrik
AU - Whelan, Rob
AU - Martinot, Jean-Luc
AU - Schumann, Gunter
AU - Paillère-Martinot, Marie-Laure
AU - IMAGEN Consortium
PY - 2015/12
Y1 - 2015/12
N2 - OBJECTIVE: The authors examined whether alterations in the brain's reward network operate as a mechanism across the spectrum of risk for depression. They then tested whether these alterations are specific to anhedonia as compared with low mood and whether they are predictive of depressive outcomes.METHOD: Functional MRI was used to collect blood-oxygen-level-dependent (BOLD) responses to anticipation of reward in the monetary incentive task in 1,576 adolescents in a community-based sample. Adolescents with current subthreshold depression and clinical depression were compared with matched healthy subjects. In addition, BOLD responses were compared across adolescents with anhedonia, low mood, or both symptoms, cross-sectionally and longitudinally.RESULTS: Activity in the ventral striatum was reduced in participants with subthreshold and clinical depression relative to healthy comparison subjects. Low ventral striatum activation predicted transition to subthreshold or clinical depression in previously healthy adolescents at 2-year follow-up. Brain responses during reward anticipation decreased in a graded manner between healthy adolescents, adolescents with current or future subthreshold depression, and adolescents with current or future clinical depression. Low ventral striatum activity was associated with anhedonia but not low mood; however, the combined presence of both symptoms showed the strongest reductions in the ventral striatum in all analyses.CONCLUSIONS: The findings suggest that reduced striatal activation operates as a mechanism across the risk spectrum for depression. It is associated with anhedonia in healthy adolescents and is a behavioral indicator of positive valence systems, consistent with predictions based on the Research Domain Criteria.
AB - OBJECTIVE: The authors examined whether alterations in the brain's reward network operate as a mechanism across the spectrum of risk for depression. They then tested whether these alterations are specific to anhedonia as compared with low mood and whether they are predictive of depressive outcomes.METHOD: Functional MRI was used to collect blood-oxygen-level-dependent (BOLD) responses to anticipation of reward in the monetary incentive task in 1,576 adolescents in a community-based sample. Adolescents with current subthreshold depression and clinical depression were compared with matched healthy subjects. In addition, BOLD responses were compared across adolescents with anhedonia, low mood, or both symptoms, cross-sectionally and longitudinally.RESULTS: Activity in the ventral striatum was reduced in participants with subthreshold and clinical depression relative to healthy comparison subjects. Low ventral striatum activation predicted transition to subthreshold or clinical depression in previously healthy adolescents at 2-year follow-up. Brain responses during reward anticipation decreased in a graded manner between healthy adolescents, adolescents with current or future subthreshold depression, and adolescents with current or future clinical depression. Low ventral striatum activity was associated with anhedonia but not low mood; however, the combined presence of both symptoms showed the strongest reductions in the ventral striatum in all analyses.CONCLUSIONS: The findings suggest that reduced striatal activation operates as a mechanism across the risk spectrum for depression. It is associated with anhedonia in healthy adolescents and is a behavioral indicator of positive valence systems, consistent with predictions based on the Research Domain Criteria.
U2 - 10.1176/appi.ajp.2015.14101298
DO - 10.1176/appi.ajp.2015.14101298
M3 - SCORING: Journal article
C2 - 26085042
VL - 172
SP - 1215
EP - 1223
JO - AM J PSYCHIAT
JF - AM J PSYCHIAT
SN - 0002-953X
IS - 12
ER -
