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The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

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The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases. / Roncarolo, Maria Grazia; Gregori, Silvia; Bacchetta, Rosa; Battaglia, Manuela; Gagliani, Nicola.

In: IMMUNITY, Vol. 49, No. 6, 18.12.2018, p. 1004-1019.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Roncarolo, MG, Gregori, S, Bacchetta, R, Battaglia, M & Gagliani, N 2018, 'The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases', IMMUNITY, vol. 49, no. 6, pp. 1004-1019. https://doi.org/10.1016/j.immuni.2018.12.001

APA

Roncarolo, M. G., Gregori, S., Bacchetta, R., Battaglia, M., & Gagliani, N. (2018). The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases. IMMUNITY, 49(6), 1004-1019. https://doi.org/10.1016/j.immuni.2018.12.001

Vancouver

Roncarolo MG, Gregori S, Bacchetta R, Battaglia M, Gagliani N. The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases. IMMUNITY. 2018 Dec 18;49(6):1004-1019. https://doi.org/10.1016/j.immuni.2018.12.001

Bibtex

@article{7b45302e08614405a9b3e4f10940f9e7,
title = "The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases",
abstract = "Thirty years ago, one of the first types of CD4+ T regulatory cells was discovered and named T regulatory type 1 (Tr1) cells. Tr1 cells represent a distinct population of T cells, which are induced in the periphery upon antigen exposure under tolerogenic conditions. They produce the immunosuppressive cytokines interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), do not constitutively express FOXP3, and suppress the function of effector immune cells. In this review, the key studies leading to the identification and biological characterization of Tr1 cells are recapitulated. The fundamental role of Tr1 cells in regulating immune responses to pathogenic and non-pathogenic antigens, as well as their use as cell therapeutics, is summarized.",
keywords = "Journal Article, Review",
author = "Roncarolo, {Maria Grazia} and Silvia Gregori and Rosa Bacchetta and Manuela Battaglia and Nicola Gagliani",
note = "Copyright {\textcopyright} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
month = dec,
day = "18",
doi = "10.1016/j.immuni.2018.12.001",
language = "English",
volume = "49",
pages = "1004--1019",
journal = "IMMUNITY",
issn = "1074-7613",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

AU - Roncarolo, Maria Grazia

AU - Gregori, Silvia

AU - Bacchetta, Rosa

AU - Battaglia, Manuela

AU - Gagliani, Nicola

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018/12/18

Y1 - 2018/12/18

N2 - Thirty years ago, one of the first types of CD4+ T regulatory cells was discovered and named T regulatory type 1 (Tr1) cells. Tr1 cells represent a distinct population of T cells, which are induced in the periphery upon antigen exposure under tolerogenic conditions. They produce the immunosuppressive cytokines interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), do not constitutively express FOXP3, and suppress the function of effector immune cells. In this review, the key studies leading to the identification and biological characterization of Tr1 cells are recapitulated. The fundamental role of Tr1 cells in regulating immune responses to pathogenic and non-pathogenic antigens, as well as their use as cell therapeutics, is summarized.

AB - Thirty years ago, one of the first types of CD4+ T regulatory cells was discovered and named T regulatory type 1 (Tr1) cells. Tr1 cells represent a distinct population of T cells, which are induced in the periphery upon antigen exposure under tolerogenic conditions. They produce the immunosuppressive cytokines interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), do not constitutively express FOXP3, and suppress the function of effector immune cells. In this review, the key studies leading to the identification and biological characterization of Tr1 cells are recapitulated. The fundamental role of Tr1 cells in regulating immune responses to pathogenic and non-pathogenic antigens, as well as their use as cell therapeutics, is summarized.

KW - Journal Article

KW - Review

U2 - 10.1016/j.immuni.2018.12.001

DO - 10.1016/j.immuni.2018.12.001

M3 - SCORING: Review article

C2 - 30566879

VL - 49

SP - 1004

EP - 1019

JO - IMMUNITY

JF - IMMUNITY

SN - 1074-7613

IS - 6

ER -