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The atypical subthalamic nucleus--an anatomical variant relevant for stereotactic targeting

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The atypical subthalamic nucleus--an anatomical variant relevant for stereotactic targeting. / Reese, René; Pinsker, Markus O; Herzog, Jan; Wodarg, Fritz; Steigerwald, Frank; Pötter-Nerger, Monika; Falk, Daniela; Deuschl, Günther; Mehdorn, H Maximilian; Volkmann, Jens.

In: MOVEMENT DISORD, Vol. 27, No. 4, 04.2012, p. 544-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Reese, R, Pinsker, MO, Herzog, J, Wodarg, F, Steigerwald, F, Pötter-Nerger, M, Falk, D, Deuschl, G, Mehdorn, HM & Volkmann, J 2012, 'The atypical subthalamic nucleus--an anatomical variant relevant for stereotactic targeting', MOVEMENT DISORD, vol. 27, no. 4, pp. 544-8. https://doi.org/10.1002/mds.24902

APA

Reese, R., Pinsker, M. O., Herzog, J., Wodarg, F., Steigerwald, F., Pötter-Nerger, M., Falk, D., Deuschl, G., Mehdorn, H. M., & Volkmann, J. (2012). The atypical subthalamic nucleus--an anatomical variant relevant for stereotactic targeting. MOVEMENT DISORD, 27(4), 544-8. https://doi.org/10.1002/mds.24902

Vancouver

Reese R, Pinsker MO, Herzog J, Wodarg F, Steigerwald F, Pötter-Nerger M et al. The atypical subthalamic nucleus--an anatomical variant relevant for stereotactic targeting. MOVEMENT DISORD. 2012 Apr;27(4):544-8. https://doi.org/10.1002/mds.24902

Bibtex

@article{67d681ec018c4a318e530e6bda0b2d92,
title = "The atypical subthalamic nucleus--an anatomical variant relevant for stereotactic targeting",
abstract = "BACKGROUND: The improvement of PD motor symptoms by DBS of the STN depends on exact targeting.METHODS: A combination of MRI and multitrajectory microrecordings was used for localization of the STN in a group of 228 consecutive PD patients.RESULTS: In 1% of our cases, the STN was consistently shifted in the anterior (3.3 ± 0.8mm) and medial (3.0 ± 0.9 mm) direction within the target plane, compared to controls. Adjustment of the original target coordinates after intraoperative reevaluation of the MRI and confirmation by typical subthalamic neuronal recordings along the deviant trajectory allowed the implantation of clinically effective electrodes in all cases. The relative improvement of the motor UPDRS at 6-months follow-up in patients with an atypical and typical STN was comparable.CONCLUSION: An atypical position of the STN does not need to complicate DBS surgery, if detected by a combination of MRI-based targeting and electrophysiological guidance.",
keywords = "Cohort Studies, Deep Brain Stimulation, Female, Humans, Magnetic Resonance Imaging, Male, Parkinson Disease, Stereotaxic Techniques, Subthalamic Nucleus, Journal Article",
author = "Ren{\'e} Reese and Pinsker, {Markus O} and Jan Herzog and Fritz Wodarg and Frank Steigerwald and Monika P{\"o}tter-Nerger and Daniela Falk and G{\"u}nther Deuschl and Mehdorn, {H Maximilian} and Jens Volkmann",
note = "Copyright {\textcopyright} 2012 Movement Disorder Society.",
year = "2012",
month = apr,
doi = "10.1002/mds.24902",
language = "English",
volume = "27",
pages = "544--8",
journal = "MOVEMENT DISORD",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - The atypical subthalamic nucleus--an anatomical variant relevant for stereotactic targeting

AU - Reese, René

AU - Pinsker, Markus O

AU - Herzog, Jan

AU - Wodarg, Fritz

AU - Steigerwald, Frank

AU - Pötter-Nerger, Monika

AU - Falk, Daniela

AU - Deuschl, Günther

AU - Mehdorn, H Maximilian

AU - Volkmann, Jens

N1 - Copyright © 2012 Movement Disorder Society.

PY - 2012/4

Y1 - 2012/4

N2 - BACKGROUND: The improvement of PD motor symptoms by DBS of the STN depends on exact targeting.METHODS: A combination of MRI and multitrajectory microrecordings was used for localization of the STN in a group of 228 consecutive PD patients.RESULTS: In 1% of our cases, the STN was consistently shifted in the anterior (3.3 ± 0.8mm) and medial (3.0 ± 0.9 mm) direction within the target plane, compared to controls. Adjustment of the original target coordinates after intraoperative reevaluation of the MRI and confirmation by typical subthalamic neuronal recordings along the deviant trajectory allowed the implantation of clinically effective electrodes in all cases. The relative improvement of the motor UPDRS at 6-months follow-up in patients with an atypical and typical STN was comparable.CONCLUSION: An atypical position of the STN does not need to complicate DBS surgery, if detected by a combination of MRI-based targeting and electrophysiological guidance.

AB - BACKGROUND: The improvement of PD motor symptoms by DBS of the STN depends on exact targeting.METHODS: A combination of MRI and multitrajectory microrecordings was used for localization of the STN in a group of 228 consecutive PD patients.RESULTS: In 1% of our cases, the STN was consistently shifted in the anterior (3.3 ± 0.8mm) and medial (3.0 ± 0.9 mm) direction within the target plane, compared to controls. Adjustment of the original target coordinates after intraoperative reevaluation of the MRI and confirmation by typical subthalamic neuronal recordings along the deviant trajectory allowed the implantation of clinically effective electrodes in all cases. The relative improvement of the motor UPDRS at 6-months follow-up in patients with an atypical and typical STN was comparable.CONCLUSION: An atypical position of the STN does not need to complicate DBS surgery, if detected by a combination of MRI-based targeting and electrophysiological guidance.

KW - Cohort Studies

KW - Deep Brain Stimulation

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Parkinson Disease

KW - Stereotaxic Techniques

KW - Subthalamic Nucleus

KW - Journal Article

U2 - 10.1002/mds.24902

DO - 10.1002/mds.24902

M3 - SCORING: Journal article

C2 - 22371222

VL - 27

SP - 544

EP - 548

JO - MOVEMENT DISORD

JF - MOVEMENT DISORD

SN - 0885-3185

IS - 4

ER -