Research ExplorerPublicationsThe association of chronic anxiousness with cardiovascular d...

The association of chronic anxiousness with cardiovascular disease and mortality in the community: results from the Gutenberg Health Study

Standard

The association of chronic anxiousness with cardiovascular disease and mortality in the community: results from the Gutenberg Health Study. / Reiner, Iris C; Tibubos, Ana N; Werner, Antonia M; Ernst, Mareike; Brähler, Elmar; Wiltink, Jörg; Michal, Matthias; Schulz, Andreas; Wild, Philipp S; Münzel, Thomas; Arnold, Natalie; Mahmoudpour, Seyed Hamidreza; Lackner, Karl J; Pfeiffer, Norbert; Beutel, Manfred E.

In: SCI REP-UK, Vol. 10, No. 1, 12436, 24.07.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Reiner, IC, Tibubos, AN, Werner, AM, Ernst, M, Brähler, E, Wiltink, J, Michal, M, Schulz, A, Wild, PS, Münzel, T, Arnold, N, Mahmoudpour, SH, Lackner, KJ, Pfeiffer, N & Beutel, ME 2020, 'The association of chronic anxiousness with cardiovascular disease and mortality in the community: results from the Gutenberg Health Study', SCI REP-UK, vol. 10, no. 1, 12436. https://doi.org/10.1038/s41598-020-69427-8

APA

Reiner, I. C., Tibubos, A. N., Werner, A. M., Ernst, M., Brähler, E., Wiltink, J., Michal, M., Schulz, A., Wild, P. S., Münzel, T., Arnold, N., Mahmoudpour, S. H., Lackner, K. J., Pfeiffer, N., & Beutel, M. E. (2020). The association of chronic anxiousness with cardiovascular disease and mortality in the community: results from the Gutenberg Health Study. SCI REP-UK, 10(1), [12436]. https://doi.org/10.1038/s41598-020-69427-8

Vancouver

Reiner IC, Tibubos AN, Werner AM, Ernst M, Brähler E, Wiltink J et al. The association of chronic anxiousness with cardiovascular disease and mortality in the community: results from the Gutenberg Health Study. SCI REP-UK. 2020 Jul 24;10(1). 12436. https://doi.org/10.1038/s41598-020-69427-8

Bibtex

@article{57d9fd2db3514d0c8e20b791ff63892c,
title = "The association of chronic anxiousness with cardiovascular disease and mortality in the community: results from the Gutenberg Health Study",
abstract = "In a large German community sample of adults, we investigated the association of chronic anxiousness with cardiovascular disease and mortality. Self-reported anxiousness from 11,643 German adults between 40 and 80 years of age from the Gutenberg Health Study (GHS) was analyzed over 5 years. Multivariable regression modeling assessed the relation between the variables, cardiovascular disease and mortality. Twelve percent of the participants reported consistently raised (chronic) anxiousness over at least 2.5 years. Anxiousness was more often reported by female, younger participants with a lower socioeconomic status, smokers and those with a family history of stroke and myocardial infarction. New onset of cardiovascular disease was linked to chronic anxiousness in men and new onset of anxiousness in women. However, chronic anxiousness did not predict all-cause mortality. Our results revealed that anxiousness is highly prevalent in German adults from middle to old age, affecting women in particular. In our study, we found sex-specific associations between new onset of cardiovascular disease and different forms of anxiousness in men and women. We suggest that even subclinical levels of anxiety need to be considered as cardiovascular risk factors. To elucidate potential harm of anxiousness for mental and physical health, we propose sex-specific analyses in further research studies, taking age and the course of anxiousness into account.",
keywords = "Adult, Age Factors, Aged, Aged, 80 and over, Anxiety/complications, Cardiovascular Diseases/epidemiology, Chronic Disease/epidemiology, Female, Germany/epidemiology, Health Status, Humans, Male, Mental Health, Middle Aged, Mortality, Prevalence, Residence Characteristics, Risk Factors, Self Report/statistics & numerical data, Sex Factors, Social Class",
author = "Reiner, {Iris C} and Tibubos, {Ana N} and Werner, {Antonia M} and Mareike Ernst and Elmar Br{\"a}hler and J{\"o}rg Wiltink and Matthias Michal and Andreas Schulz and Wild, {Philipp S} and Thomas M{\"u}nzel and Natalie Arnold and Mahmoudpour, {Seyed Hamidreza} and Lackner, {Karl J} and Norbert Pfeiffer and Beutel, {Manfred E}",
year = "2020",
month = jul,
day = "24",
doi = "10.1038/s41598-020-69427-8",
language = "English",
volume = "10",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - The association of chronic anxiousness with cardiovascular disease and mortality in the community: results from the Gutenberg Health Study

AU - Reiner, Iris C

AU - Tibubos, Ana N

AU - Werner, Antonia M

AU - Ernst, Mareike

AU - Brähler, Elmar

AU - Wiltink, Jörg

AU - Michal, Matthias

AU - Schulz, Andreas

AU - Wild, Philipp S

AU - Münzel, Thomas

AU - Arnold, Natalie

AU - Mahmoudpour, Seyed Hamidreza

AU - Lackner, Karl J

AU - Pfeiffer, Norbert

AU - Beutel, Manfred E

PY - 2020/7/24

Y1 - 2020/7/24

N2 - In a large German community sample of adults, we investigated the association of chronic anxiousness with cardiovascular disease and mortality. Self-reported anxiousness from 11,643 German adults between 40 and 80 years of age from the Gutenberg Health Study (GHS) was analyzed over 5 years. Multivariable regression modeling assessed the relation between the variables, cardiovascular disease and mortality. Twelve percent of the participants reported consistently raised (chronic) anxiousness over at least 2.5 years. Anxiousness was more often reported by female, younger participants with a lower socioeconomic status, smokers and those with a family history of stroke and myocardial infarction. New onset of cardiovascular disease was linked to chronic anxiousness in men and new onset of anxiousness in women. However, chronic anxiousness did not predict all-cause mortality. Our results revealed that anxiousness is highly prevalent in German adults from middle to old age, affecting women in particular. In our study, we found sex-specific associations between new onset of cardiovascular disease and different forms of anxiousness in men and women. We suggest that even subclinical levels of anxiety need to be considered as cardiovascular risk factors. To elucidate potential harm of anxiousness for mental and physical health, we propose sex-specific analyses in further research studies, taking age and the course of anxiousness into account.

AB - In a large German community sample of adults, we investigated the association of chronic anxiousness with cardiovascular disease and mortality. Self-reported anxiousness from 11,643 German adults between 40 and 80 years of age from the Gutenberg Health Study (GHS) was analyzed over 5 years. Multivariable regression modeling assessed the relation between the variables, cardiovascular disease and mortality. Twelve percent of the participants reported consistently raised (chronic) anxiousness over at least 2.5 years. Anxiousness was more often reported by female, younger participants with a lower socioeconomic status, smokers and those with a family history of stroke and myocardial infarction. New onset of cardiovascular disease was linked to chronic anxiousness in men and new onset of anxiousness in women. However, chronic anxiousness did not predict all-cause mortality. Our results revealed that anxiousness is highly prevalent in German adults from middle to old age, affecting women in particular. In our study, we found sex-specific associations between new onset of cardiovascular disease and different forms of anxiousness in men and women. We suggest that even subclinical levels of anxiety need to be considered as cardiovascular risk factors. To elucidate potential harm of anxiousness for mental and physical health, we propose sex-specific analyses in further research studies, taking age and the course of anxiousness into account.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Anxiety/complications

KW - Cardiovascular Diseases/epidemiology

KW - Chronic Disease/epidemiology

KW - Female

KW - Germany/epidemiology

KW - Health Status

KW - Humans

KW - Male

KW - Mental Health

KW - Middle Aged

KW - Mortality

KW - Prevalence

KW - Residence Characteristics

KW - Risk Factors

KW - Self Report/statistics & numerical data

KW - Sex Factors

KW - Social Class

U2 - 10.1038/s41598-020-69427-8

DO - 10.1038/s41598-020-69427-8

M3 - SCORING: Journal article

C2 - 32709910

VL - 10

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

M1 - 12436

ER -