The asphericity of the metabolic tumour volume in NSCLC: correlation with histopathology and molecular markers
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The asphericity of the metabolic tumour volume in NSCLC: correlation with histopathology and molecular markers. / Apostolova, Ivayla; Ego, Kilian; Steffen, Ingo G; Buchert, Ralph; Wertzel, Heinz; Achenbach, H Jost; Riedel, Sandra; Schreiber, Jens; Schultz, Meinald; Furth, Christian; Derlin, Thorsten; Amthauer, Holger; Hofheinz, Frank; Kalinski, Thomas.
In: EUR J NUCL MED MOL I, Vol. 43, No. 13, 12.2016, p. 2360-2373.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The asphericity of the metabolic tumour volume in NSCLC: correlation with histopathology and molecular markers
AU - Apostolova, Ivayla
AU - Ego, Kilian
AU - Steffen, Ingo G
AU - Buchert, Ralph
AU - Wertzel, Heinz
AU - Achenbach, H Jost
AU - Riedel, Sandra
AU - Schreiber, Jens
AU - Schultz, Meinald
AU - Furth, Christian
AU - Derlin, Thorsten
AU - Amthauer, Holger
AU - Hofheinz, Frank
AU - Kalinski, Thomas
PY - 2016/12
Y1 - 2016/12
N2 - PURPOSE: Asphericity (ASP) is a tumour shape descriptor based on the PET image. It quantitates the deviation from spherical of the shape of the metabolic tumour volume (MTV). In order to identify its biological correlates, we investigated the relationship between ASP and clinically relevant histopathological and molecular signatures in non-small-cell lung cancer (NSCLC).METHODS: The study included 83 consecutive patients (18 women, aged 66.4 ± 8.9 years) with newly diagnosed NSCLC in whom PET/CT with (18)F-FDG had been performed prior to therapy. Primary tumour resection specimens and core biopsies were used for basic histopathology and determination of the Ki-67 proliferation index. EGFR status, VEGF, p53 and ALK expression were obtained in a subgroup of 44 patients. The FDG PET images of the primary tumours were delineated using an automatic algorithm based on adaptive thresholding taking into account local background. In addition to ASP, SUVmax, MTV and some further descriptors of shape and intratumour heterogeneity were assessed as semiquantitative PET measures.RESULTS: SUVmax, MTV and ASP were associated with pathological T stage (Kruskal-Wallis, p = 0.001, p < 0.0005 and p < 0.0005, respectively) and N stage (p = 0.017, p = 0.003 and p = 0.002, respectively). Only ASP was associated with M stage (p = 0.026). SUVmax, MTV and ASP were correlated with Ki-67 index (Spearman's rho = 0.326/p = 0.003, rho = 0.302/p = 0.006 and rho = 0.271/p = 0.015, respectively). The latter correlations were considerably stronger in adenocarcinomas than in squamous cell carcinomas. ASP, but not SUVmax or MTV, showed a tendency for a significant association with the extent of VEGF expression (p = 0.058). In multivariate Cox regression analysis, ASP (p < 0.0005) and the presence of distant metastases (p = 0.023) were significantly associated with progression-free survival. ASP (p = 0.006), the presence of distant metastases (p = 0.010), and Ki-67 index (p = 0.062) were significantly associated with overall survival.CONCLUSION: The ASP of primary NSCLCs on FDG PET images is associated with tumour dimensions and molecular markers of proliferation and angiogenesis.
AB - PURPOSE: Asphericity (ASP) is a tumour shape descriptor based on the PET image. It quantitates the deviation from spherical of the shape of the metabolic tumour volume (MTV). In order to identify its biological correlates, we investigated the relationship between ASP and clinically relevant histopathological and molecular signatures in non-small-cell lung cancer (NSCLC).METHODS: The study included 83 consecutive patients (18 women, aged 66.4 ± 8.9 years) with newly diagnosed NSCLC in whom PET/CT with (18)F-FDG had been performed prior to therapy. Primary tumour resection specimens and core biopsies were used for basic histopathology and determination of the Ki-67 proliferation index. EGFR status, VEGF, p53 and ALK expression were obtained in a subgroup of 44 patients. The FDG PET images of the primary tumours were delineated using an automatic algorithm based on adaptive thresholding taking into account local background. In addition to ASP, SUVmax, MTV and some further descriptors of shape and intratumour heterogeneity were assessed as semiquantitative PET measures.RESULTS: SUVmax, MTV and ASP were associated with pathological T stage (Kruskal-Wallis, p = 0.001, p < 0.0005 and p < 0.0005, respectively) and N stage (p = 0.017, p = 0.003 and p = 0.002, respectively). Only ASP was associated with M stage (p = 0.026). SUVmax, MTV and ASP were correlated with Ki-67 index (Spearman's rho = 0.326/p = 0.003, rho = 0.302/p = 0.006 and rho = 0.271/p = 0.015, respectively). The latter correlations were considerably stronger in adenocarcinomas than in squamous cell carcinomas. ASP, but not SUVmax or MTV, showed a tendency for a significant association with the extent of VEGF expression (p = 0.058). In multivariate Cox regression analysis, ASP (p < 0.0005) and the presence of distant metastases (p = 0.023) were significantly associated with progression-free survival. ASP (p = 0.006), the presence of distant metastases (p = 0.010), and Ki-67 index (p = 0.062) were significantly associated with overall survival.CONCLUSION: The ASP of primary NSCLCs on FDG PET images is associated with tumour dimensions and molecular markers of proliferation and angiogenesis.
KW - Aged
KW - Aged, 80 and over
KW - Algorithms
KW - Biomarkers, Tumor
KW - Carcinoma, Non-Small-Cell Lung
KW - Female
KW - Fluorodeoxyglucose F18
KW - Humans
KW - Image Interpretation, Computer-Assisted
KW - Lung Neoplasms
KW - Male
KW - Middle Aged
KW - Neoplasm Staging
KW - Positron-Emission Tomography
KW - Radiopharmaceuticals
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Tumor Burden
KW - Journal Article
U2 - 10.1007/s00259-016-3452-z
DO - 10.1007/s00259-016-3452-z
M3 - SCORING: Journal article
C2 - 27470327
VL - 43
SP - 2360
EP - 2373
JO - EUR J NUCL MED MOL I
JF - EUR J NUCL MED MOL I
SN - 1619-7070
IS - 13
ER -
