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The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

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The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity. / Christoffersen, Christina; Federspiel, Christine K; Borup, Anna; Christensen, Pernille M; Madsen, Andreas N; Heine, Markus; Nielsen, Carsten H; Kjaer, Andreas; Holst, Birgitte; Heeren, Joerg; Nielsen, Lars B.

In: CELL REP, Vol. 22, No. 1, 02.01.2018, p. 175-188.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Christoffersen, C, Federspiel, CK, Borup, A, Christensen, PM, Madsen, AN, Heine, M, Nielsen, CH, Kjaer, A, Holst, B, Heeren, J & Nielsen, LB 2018, 'The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity', CELL REP, vol. 22, no. 1, pp. 175-188. https://doi.org/10.1016/j.celrep.2017.12.029

APA

Christoffersen, C., Federspiel, C. K., Borup, A., Christensen, P. M., Madsen, A. N., Heine, M., Nielsen, C. H., Kjaer, A., Holst, B., Heeren, J., & Nielsen, L. B. (2018). The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity. CELL REP, 22(1), 175-188. https://doi.org/10.1016/j.celrep.2017.12.029

Vancouver

Christoffersen C, Federspiel CK, Borup A, Christensen PM, Madsen AN, Heine M et al. The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity. CELL REP. 2018 Jan 2;22(1):175-188. https://doi.org/10.1016/j.celrep.2017.12.029

Bibtex

@article{f8bd0d375a984c51a5c51c62f8844c78,
title = "The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity",
abstract = "Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism.",
keywords = "Journal Article",
author = "Christina Christoffersen and Federspiel, {Christine K} and Anna Borup and Christensen, {Pernille M} and Madsen, {Andreas N} and Markus Heine and Nielsen, {Carsten H} and Andreas Kjaer and Birgitte Holst and Joerg Heeren and Nielsen, {Lars B}",
note = "Copyright {\textcopyright} 2017 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = jan,
day = "2",
doi = "10.1016/j.celrep.2017.12.029",
language = "English",
volume = "22",
pages = "175--188",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

AU - Christoffersen, Christina

AU - Federspiel, Christine K

AU - Borup, Anna

AU - Christensen, Pernille M

AU - Madsen, Andreas N

AU - Heine, Markus

AU - Nielsen, Carsten H

AU - Kjaer, Andreas

AU - Holst, Birgitte

AU - Heeren, Joerg

AU - Nielsen, Lars B

N1 - Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2018/1/2

Y1 - 2018/1/2

N2 - Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism.

AB - Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism.

KW - Journal Article

U2 - 10.1016/j.celrep.2017.12.029

DO - 10.1016/j.celrep.2017.12.029

M3 - SCORING: Journal article

C2 - 29298420

VL - 22

SP - 175

EP - 188

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 1

ER -