The aging prostate is never "normal": implications from the genomic characterization of multifocal prostate cancers

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The aging prostate is never "normal": implications from the genomic characterization of multifocal prostate cancers. / Schlomm, Thorsten; Weischenfeldt, Joachim; Korbel, Jan; Sauter, Guido.

In: EUR UROL, Vol. 68, No. 3, 09.2015, p. 348-50.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

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@article{6eb62cf2f0c248a2bc3a32bd14cd86d9,
title = "The aging prostate is never {"}normal{"}: implications from the genomic characterization of multifocal prostate cancers",
abstract = "We argue against the recently published statement that tumor-specific molecular alterations found in {"}normal{"} prostate tissue from cancer patients challenge focal therapy approaches that only target a visible cancer lesion and not the adjacent molecular field.",
keywords = "Aging, Genetic Heterogeneity, Genomics, Humans, Male, Neoplasms, Multiple Primary, Oncogene Proteins, Fusion, Prostate, Prostatic Neoplasms, Editorial",
author = "Thorsten Schlomm and Joachim Weischenfeldt and Jan Korbel and Guido Sauter",
note = "Copyright {\textcopyright} 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.",
year = "2015",
month = sep,
doi = "10.1016/j.eururo.2015.04.012",
language = "English",
volume = "68",
pages = "348--50",
journal = "EUR UROL",
issn = "0302-2838",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - The aging prostate is never "normal": implications from the genomic characterization of multifocal prostate cancers

AU - Schlomm, Thorsten

AU - Weischenfeldt, Joachim

AU - Korbel, Jan

AU - Sauter, Guido

N1 - Copyright © 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.

PY - 2015/9

Y1 - 2015/9

N2 - We argue against the recently published statement that tumor-specific molecular alterations found in "normal" prostate tissue from cancer patients challenge focal therapy approaches that only target a visible cancer lesion and not the adjacent molecular field.

AB - We argue against the recently published statement that tumor-specific molecular alterations found in "normal" prostate tissue from cancer patients challenge focal therapy approaches that only target a visible cancer lesion and not the adjacent molecular field.

KW - Aging

KW - Genetic Heterogeneity

KW - Genomics

KW - Humans

KW - Male

KW - Neoplasms, Multiple Primary

KW - Oncogene Proteins, Fusion

KW - Prostate

KW - Prostatic Neoplasms

KW - Editorial

U2 - 10.1016/j.eururo.2015.04.012

DO - 10.1016/j.eururo.2015.04.012

M3 - SCORING: Journal article

C2 - 25913065

VL - 68

SP - 348

EP - 350

JO - EUR UROL

JF - EUR UROL

SN - 0302-2838

IS - 3

ER -