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The 5-HTTLPR genotype modulates heart rate variability and its adjustment by pharmacological panic challenge in healthy men

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The 5-HTTLPR genotype modulates heart rate variability and its adjustment by pharmacological panic challenge in healthy men. / Agorastos, Agorastos; Kellner, Michael; Stiedl, Oliver; Muhtz, Christoph; Becktepe, Jos S; Wiedemann, Klaus; Demiralay, Cüneyt.

In: J PSYCHIATR RES, Vol. 50, 01.03.2014, p. 51-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Agorastos, A, Kellner, M, Stiedl, O, Muhtz, C, Becktepe, JS, Wiedemann, K & Demiralay, C 2014, 'The 5-HTTLPR genotype modulates heart rate variability and its adjustment by pharmacological panic challenge in healthy men', J PSYCHIATR RES, vol. 50, pp. 51-8. https://doi.org/10.1016/j.jpsychires.2013.11.013

APA

Agorastos, A., Kellner, M., Stiedl, O., Muhtz, C., Becktepe, J. S., Wiedemann, K., & Demiralay, C. (2014). The 5-HTTLPR genotype modulates heart rate variability and its adjustment by pharmacological panic challenge in healthy men. J PSYCHIATR RES, 50, 51-8. https://doi.org/10.1016/j.jpsychires.2013.11.013

Vancouver

Agorastos A, Kellner M, Stiedl O, Muhtz C, Becktepe JS, Wiedemann K et al. The 5-HTTLPR genotype modulates heart rate variability and its adjustment by pharmacological panic challenge in healthy men. J PSYCHIATR RES. 2014 Mar 1;50:51-8. https://doi.org/10.1016/j.jpsychires.2013.11.013

Bibtex

@article{627a1817af9d422581abc3ed77b5f18b,
title = "The 5-HTTLPR genotype modulates heart rate variability and its adjustment by pharmacological panic challenge in healthy men",
abstract = "Abnormal serotonin transporter (5-HTT) function and autonomic nervous system (ANS) dysregulation has been proposed in panic disorder. However, in contrast to hypothalamo-pituitary-adrenocortical (HPA) functioning, ANS reactivity during panic response has yet not been investigated in humans with respect to the 5-HTT genotype. The present study assessed the influence of challenging by cholecystokinin tetrapeptide (CCK-4) on heart rate variability (HRV) measures, to monitor autonomic reactivity and its relationship to 5-HTT-linked polymorphic region (5-HTTLPR) genotypes. We hypothesized substantial effects of the 5-HTTLPR genotype on autonomic reactivity. We studied 30 healthy young men, 15 of each with the long/long (l/l) or short/short (s/s) genotype for the 5-HTTLPR. All participants received an intravenous application of 50 μg CCK-4. HRV measures were assessed in both groups at baseline and immediately after CCK-4 application. Our results indicated lower parasympathetic activity in s/s carriers during baseline, time and frequency domain measures. CCK-4 application significantly enhanced the sympathetic tone in both groups, leading to diminished group differences. A significant treatment by genotype effect indicated reduced autonomic reactivity to CCK-4 challenge in the s/s compared to l/l carriers. Our findings show enhanced sympathetic and/or diminished cardiac vagal activity under basal conditions and blunted autonomic reactivity in s/s vs. l/l carriers. Our study provides novel data supporting claims that the s/s genotype represents a genetic vulnerability factor associated with inadequate hyporeactivity to stress and extends current knowledge on the impact of the central serotonergic activity on the sympathoadrenal pathway.",
author = "Agorastos Agorastos and Michael Kellner and Oliver Stiedl and Christoph Muhtz and Becktepe, {Jos S} and Klaus Wiedemann and C{\"u}neyt Demiralay",
note = "Copyright {\textcopyright} 2013 Elsevier Ltd. All rights reserved.",
year = "2014",
month = mar,
day = "1",
doi = "10.1016/j.jpsychires.2013.11.013",
language = "English",
volume = "50",
pages = "51--8",
journal = "J PSYCHIATR RES",
issn = "0022-3956",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - The 5-HTTLPR genotype modulates heart rate variability and its adjustment by pharmacological panic challenge in healthy men

AU - Agorastos, Agorastos

AU - Kellner, Michael

AU - Stiedl, Oliver

AU - Muhtz, Christoph

AU - Becktepe, Jos S

AU - Wiedemann, Klaus

AU - Demiralay, Cüneyt

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Abnormal serotonin transporter (5-HTT) function and autonomic nervous system (ANS) dysregulation has been proposed in panic disorder. However, in contrast to hypothalamo-pituitary-adrenocortical (HPA) functioning, ANS reactivity during panic response has yet not been investigated in humans with respect to the 5-HTT genotype. The present study assessed the influence of challenging by cholecystokinin tetrapeptide (CCK-4) on heart rate variability (HRV) measures, to monitor autonomic reactivity and its relationship to 5-HTT-linked polymorphic region (5-HTTLPR) genotypes. We hypothesized substantial effects of the 5-HTTLPR genotype on autonomic reactivity. We studied 30 healthy young men, 15 of each with the long/long (l/l) or short/short (s/s) genotype for the 5-HTTLPR. All participants received an intravenous application of 50 μg CCK-4. HRV measures were assessed in both groups at baseline and immediately after CCK-4 application. Our results indicated lower parasympathetic activity in s/s carriers during baseline, time and frequency domain measures. CCK-4 application significantly enhanced the sympathetic tone in both groups, leading to diminished group differences. A significant treatment by genotype effect indicated reduced autonomic reactivity to CCK-4 challenge in the s/s compared to l/l carriers. Our findings show enhanced sympathetic and/or diminished cardiac vagal activity under basal conditions and blunted autonomic reactivity in s/s vs. l/l carriers. Our study provides novel data supporting claims that the s/s genotype represents a genetic vulnerability factor associated with inadequate hyporeactivity to stress and extends current knowledge on the impact of the central serotonergic activity on the sympathoadrenal pathway.

AB - Abnormal serotonin transporter (5-HTT) function and autonomic nervous system (ANS) dysregulation has been proposed in panic disorder. However, in contrast to hypothalamo-pituitary-adrenocortical (HPA) functioning, ANS reactivity during panic response has yet not been investigated in humans with respect to the 5-HTT genotype. The present study assessed the influence of challenging by cholecystokinin tetrapeptide (CCK-4) on heart rate variability (HRV) measures, to monitor autonomic reactivity and its relationship to 5-HTT-linked polymorphic region (5-HTTLPR) genotypes. We hypothesized substantial effects of the 5-HTTLPR genotype on autonomic reactivity. We studied 30 healthy young men, 15 of each with the long/long (l/l) or short/short (s/s) genotype for the 5-HTTLPR. All participants received an intravenous application of 50 μg CCK-4. HRV measures were assessed in both groups at baseline and immediately after CCK-4 application. Our results indicated lower parasympathetic activity in s/s carriers during baseline, time and frequency domain measures. CCK-4 application significantly enhanced the sympathetic tone in both groups, leading to diminished group differences. A significant treatment by genotype effect indicated reduced autonomic reactivity to CCK-4 challenge in the s/s compared to l/l carriers. Our findings show enhanced sympathetic and/or diminished cardiac vagal activity under basal conditions and blunted autonomic reactivity in s/s vs. l/l carriers. Our study provides novel data supporting claims that the s/s genotype represents a genetic vulnerability factor associated with inadequate hyporeactivity to stress and extends current knowledge on the impact of the central serotonergic activity on the sympathoadrenal pathway.

U2 - 10.1016/j.jpsychires.2013.11.013

DO - 10.1016/j.jpsychires.2013.11.013

M3 - SCORING: Journal article

C2 - 24342768

VL - 50

SP - 51

EP - 58

JO - J PSYCHIATR RES

JF - J PSYCHIATR RES

SN - 0022-3956

ER -