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The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy.

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The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy. / Chun, Felix K-H; Briganti, Alberto; Lebeau, Thierry; Fradet, Vincent; Steuber, Thomas; Walz, Jochen; Schlomm, Thorsten; Eichelberg, Christian; Haese, Alexander; Erbersdobler, Andreas; McCormack, Michael; Perrotte, Paul; Graefen, Markus; Huland, Hartwig; Karakiewicz, Pierre I.

In: EUR UROL, Vol. 49, No. 2, 2, 2006, p. 273-279.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Chun, FK-H, Briganti, A, Lebeau, T, Fradet, V, Steuber, T, Walz, J, Schlomm, T, Eichelberg, C, Haese, A, Erbersdobler, A, McCormack, M, Perrotte, P, Graefen, M, Huland, H & Karakiewicz, PI 2006, 'The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy.', EUR UROL, vol. 49, no. 2, 2, pp. 273-279. <http://www.ncbi.nlm.nih.gov/pubmed/16413103?dopt=Citation>

APA

Chun, F. K-H., Briganti, A., Lebeau, T., Fradet, V., Steuber, T., Walz, J., Schlomm, T., Eichelberg, C., Haese, A., Erbersdobler, A., McCormack, M., Perrotte, P., Graefen, M., Huland, H., & Karakiewicz, P. I. (2006). The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy. EUR UROL, 49(2), 273-279. [2]. http://www.ncbi.nlm.nih.gov/pubmed/16413103?dopt=Citation

Vancouver

Chun FK-H, Briganti A, Lebeau T, Fradet V, Steuber T, Walz J et al. The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy. EUR UROL. 2006;49(2):273-279. 2.

Bibtex

@article{54af44178f4142fc926fc126562901ab,
title = "The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy.",
abstract = "INTRODUCTION: We examined the prognostic value of AJCC pT2 substages in prediction of biochemical recurrence (BCR) after radical prostatectomy (RP), in European patients. METHODS: A cohort of 1726 RP patients with pT2N0 prostate cancer (PCa) was studied. Multivariate Cox regression models addressed the association between either the 1997 or 1992/2002 pT2 substages after controlling for total PSA, primary and secondary pathologic Gleason scores and surgical margin status and time to PSA recurrence (PSA >0.1 and rising) after RP. Regression coefficients were then used to test the predictive accuracy of multivariate models in a nomogram setting. RESULTS: PSA recurrence occurred in 80 (4.6%) patients. Mean and median times to recurrence were respectively 28.9 and 24.4 months. In univariate analyses, neither the 1997 (p = 0.48) nor the 1992/2002 pT2 substages (p = 0.054) were predictive of recurrence. In multivariate analyses the lack of significance persisted (1997 p = 0.709; 1992/2002 p = 0.124). When either the 1997 or 1992/2002 pT2 substages were added to a multivariate nomogram without pT2 substage information, its accuracy respectively decreased by 0.8% and 1.1%. CONCLUSION: Our data indicate that pT2 substages offer no incremental value relative to pre-treatment total PSA, surgical margin status and pathologic Gleason scores. Therefore, it might be postulated that it is sufficient to confirm organ confinement according to Partin's pathologic staging.",
author = "Chun, {Felix K-H} and Alberto Briganti and Thierry Lebeau and Vincent Fradet and Thomas Steuber and Jochen Walz and Thorsten Schlomm and Christian Eichelberg and Alexander Haese and Andreas Erbersdobler and Michael McCormack and Paul Perrotte and Markus Graefen and Hartwig Huland and Karakiewicz, {Pierre I}",
year = "2006",
language = "Deutsch",
volume = "49",
pages = "273--279",
journal = "EUR UROL",
issn = "0302-2838",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy.

AU - Chun, Felix K-H

AU - Briganti, Alberto

AU - Lebeau, Thierry

AU - Fradet, Vincent

AU - Steuber, Thomas

AU - Walz, Jochen

AU - Schlomm, Thorsten

AU - Eichelberg, Christian

AU - Haese, Alexander

AU - Erbersdobler, Andreas

AU - McCormack, Michael

AU - Perrotte, Paul

AU - Graefen, Markus

AU - Huland, Hartwig

AU - Karakiewicz, Pierre I

PY - 2006

Y1 - 2006

N2 - INTRODUCTION: We examined the prognostic value of AJCC pT2 substages in prediction of biochemical recurrence (BCR) after radical prostatectomy (RP), in European patients. METHODS: A cohort of 1726 RP patients with pT2N0 prostate cancer (PCa) was studied. Multivariate Cox regression models addressed the association between either the 1997 or 1992/2002 pT2 substages after controlling for total PSA, primary and secondary pathologic Gleason scores and surgical margin status and time to PSA recurrence (PSA >0.1 and rising) after RP. Regression coefficients were then used to test the predictive accuracy of multivariate models in a nomogram setting. RESULTS: PSA recurrence occurred in 80 (4.6%) patients. Mean and median times to recurrence were respectively 28.9 and 24.4 months. In univariate analyses, neither the 1997 (p = 0.48) nor the 1992/2002 pT2 substages (p = 0.054) were predictive of recurrence. In multivariate analyses the lack of significance persisted (1997 p = 0.709; 1992/2002 p = 0.124). When either the 1997 or 1992/2002 pT2 substages were added to a multivariate nomogram without pT2 substage information, its accuracy respectively decreased by 0.8% and 1.1%. CONCLUSION: Our data indicate that pT2 substages offer no incremental value relative to pre-treatment total PSA, surgical margin status and pathologic Gleason scores. Therefore, it might be postulated that it is sufficient to confirm organ confinement according to Partin's pathologic staging.

AB - INTRODUCTION: We examined the prognostic value of AJCC pT2 substages in prediction of biochemical recurrence (BCR) after radical prostatectomy (RP), in European patients. METHODS: A cohort of 1726 RP patients with pT2N0 prostate cancer (PCa) was studied. Multivariate Cox regression models addressed the association between either the 1997 or 1992/2002 pT2 substages after controlling for total PSA, primary and secondary pathologic Gleason scores and surgical margin status and time to PSA recurrence (PSA >0.1 and rising) after RP. Regression coefficients were then used to test the predictive accuracy of multivariate models in a nomogram setting. RESULTS: PSA recurrence occurred in 80 (4.6%) patients. Mean and median times to recurrence were respectively 28.9 and 24.4 months. In univariate analyses, neither the 1997 (p = 0.48) nor the 1992/2002 pT2 substages (p = 0.054) were predictive of recurrence. In multivariate analyses the lack of significance persisted (1997 p = 0.709; 1992/2002 p = 0.124). When either the 1997 or 1992/2002 pT2 substages were added to a multivariate nomogram without pT2 substage information, its accuracy respectively decreased by 0.8% and 1.1%. CONCLUSION: Our data indicate that pT2 substages offer no incremental value relative to pre-treatment total PSA, surgical margin status and pathologic Gleason scores. Therefore, it might be postulated that it is sufficient to confirm organ confinement according to Partin's pathologic staging.

M3 - SCORING: Zeitschriftenaufsatz

VL - 49

SP - 273

EP - 279

JO - EUR UROL

JF - EUR UROL

SN - 0302-2838

IS - 2

M1 - 2

ER -