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Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection

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Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection. / Licona-Limón, Paula; Henao-Mejia, Jorge; Temann, Angela U; Gagliani, Nicola; Licona-Limón, Ileana; Ishigame, Harumichi; Hao, Liming; Herbert, De'broski R; Flavell, Richard A.

In: IMMUNITY, Vol. 39, No. 4, 17.10.2013, p. 744-57.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Licona-Limón, P, Henao-Mejia, J, Temann, AU, Gagliani, N, Licona-Limón, I, Ishigame, H, Hao, L, Herbert, DR & Flavell, RA 2013, 'Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection', IMMUNITY, vol. 39, no. 4, pp. 744-57. https://doi.org/10.1016/j.immuni.2013.07.020

APA

Licona-Limón, P., Henao-Mejia, J., Temann, A. U., Gagliani, N., Licona-Limón, I., Ishigame, H., Hao, L., Herbert, D. R., & Flavell, R. A. (2013). Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection. IMMUNITY, 39(4), 744-57. https://doi.org/10.1016/j.immuni.2013.07.020

Vancouver

Licona-Limón P, Henao-Mejia J, Temann AU, Gagliani N, Licona-Limón I, Ishigame H et al. Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection. IMMUNITY. 2013 Oct 17;39(4):744-57. https://doi.org/10.1016/j.immuni.2013.07.020

Bibtex

@article{004908618f584e40a64a304ab5137877,
title = "Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection",
abstract = "Type 2 inflammatory cytokines, including interleukin-4 (IL-4), IL-5, IL-9, and IL-13, drive the characteristic features of immunity against parasitic worms and allergens. Whether IL-9 serves an essential role in the initiation of host-protective responses is controversial, and the importance of IL-9- versus IL-4-producing CD4⁺ effector T cells in type 2 immunity is incompletely defined. Herein, we generated IL-9-deficient and IL-9-fluorescent reporter mice that demonstrated an essential role for this cytokine in the early type 2 immunity against Nippostrongylus brasiliensis. Whereas T helper 9 (Th9) cells and type 2 innate lymphoid cells (ILC2s) were major sources of infection-induced IL-9 production, the adoptive transfer of Th9 cells, but not Th2 cells, caused rapid worm expulsion, marked basophilia, and increased mast cell numbers in Rag2-deficient hosts. Taken together, our data show a critical and nonredundant role for Th9 cells and IL-9 in host-protective type 2 immunity against parasitic worm infection.",
keywords = "Adoptive Transfer, Animals, DNA-Binding Proteins, Gene Expression Regulation, Immunity, Cellular, Interleukin-4, Interleukin-9, Intestines, Lectins, C-Type, Male, Mice, Mice, Knockout, Nippostrongylus, Signal Transduction, Strongylida Infections, T-Lymphocytes, Helper-Inducer, Journal Article, Research Support, Non-U.S. Gov't",
author = "Paula Licona-Lim{\'o}n and Jorge Henao-Mejia and Temann, {Angela U} and Nicola Gagliani and Ileana Licona-Lim{\'o}n and Harumichi Ishigame and Liming Hao and Herbert, {De'broski R} and Flavell, {Richard A}",
note = "Copyright {\textcopyright} 2013 Elsevier Inc. All rights reserved.",
year = "2013",
month = oct,
day = "17",
doi = "10.1016/j.immuni.2013.07.020",
language = "English",
volume = "39",
pages = "744--57",
journal = "IMMUNITY",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection

AU - Licona-Limón, Paula

AU - Henao-Mejia, Jorge

AU - Temann, Angela U

AU - Gagliani, Nicola

AU - Licona-Limón, Ileana

AU - Ishigame, Harumichi

AU - Hao, Liming

AU - Herbert, De'broski R

AU - Flavell, Richard A

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2013/10/17

Y1 - 2013/10/17

N2 - Type 2 inflammatory cytokines, including interleukin-4 (IL-4), IL-5, IL-9, and IL-13, drive the characteristic features of immunity against parasitic worms and allergens. Whether IL-9 serves an essential role in the initiation of host-protective responses is controversial, and the importance of IL-9- versus IL-4-producing CD4⁺ effector T cells in type 2 immunity is incompletely defined. Herein, we generated IL-9-deficient and IL-9-fluorescent reporter mice that demonstrated an essential role for this cytokine in the early type 2 immunity against Nippostrongylus brasiliensis. Whereas T helper 9 (Th9) cells and type 2 innate lymphoid cells (ILC2s) were major sources of infection-induced IL-9 production, the adoptive transfer of Th9 cells, but not Th2 cells, caused rapid worm expulsion, marked basophilia, and increased mast cell numbers in Rag2-deficient hosts. Taken together, our data show a critical and nonredundant role for Th9 cells and IL-9 in host-protective type 2 immunity against parasitic worm infection.

AB - Type 2 inflammatory cytokines, including interleukin-4 (IL-4), IL-5, IL-9, and IL-13, drive the characteristic features of immunity against parasitic worms and allergens. Whether IL-9 serves an essential role in the initiation of host-protective responses is controversial, and the importance of IL-9- versus IL-4-producing CD4⁺ effector T cells in type 2 immunity is incompletely defined. Herein, we generated IL-9-deficient and IL-9-fluorescent reporter mice that demonstrated an essential role for this cytokine in the early type 2 immunity against Nippostrongylus brasiliensis. Whereas T helper 9 (Th9) cells and type 2 innate lymphoid cells (ILC2s) were major sources of infection-induced IL-9 production, the adoptive transfer of Th9 cells, but not Th2 cells, caused rapid worm expulsion, marked basophilia, and increased mast cell numbers in Rag2-deficient hosts. Taken together, our data show a critical and nonredundant role for Th9 cells and IL-9 in host-protective type 2 immunity against parasitic worm infection.

KW - Adoptive Transfer

KW - Animals

KW - DNA-Binding Proteins

KW - Gene Expression Regulation

KW - Immunity, Cellular

KW - Interleukin-4

KW - Interleukin-9

KW - Intestines

KW - Lectins, C-Type

KW - Male

KW - Mice

KW - Mice, Knockout

KW - Nippostrongylus

KW - Signal Transduction

KW - Strongylida Infections

KW - T-Lymphocytes, Helper-Inducer

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.immuni.2013.07.020

DO - 10.1016/j.immuni.2013.07.020

M3 - SCORING: Journal article

C2 - 24138883

VL - 39

SP - 744

EP - 757

JO - IMMUNITY

JF - IMMUNITY

SN - 1074-7613

IS - 4

ER -