TH17 cell immune adaptation

Theodora Agalioti; Filippo Cortesi; Nicola Gagliani

doi:10.1016/j.coi.2023.102333

TH17 cell immune adaptation

Standard

TH17 cell immune adaptation. / Agalioti, Theodora ; Cortesi, Filippo ; Gagliani, Nicola.

In: CURR OPIN IMMUNOL, Vol. 83, 08.2023, p. 102333.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Agalioti, T , Cortesi, F & Gagliani, N 2023, 'TH17 cell immune adaptation', CURR OPIN IMMUNOL, vol. 83, pp. 102333. https://doi.org/10.1016/j.coi.2023.102333

APA

Agalioti, T., Cortesi, F., & Gagliani, N. (2023). TH17 cell immune adaptation. CURR OPIN IMMUNOL, 83, 102333. https://doi.org/10.1016/j.coi.2023.102333

Vancouver

Agalioti T , Cortesi F , Gagliani N. TH17 cell immune adaptation. CURR OPIN IMMUNOL. 2023 Aug;83:102333. https://doi.org/10.1016/j.coi.2023.102333

Bibtex

@article{9870a40e79f543bc88e418be5b45cd18,

title = "TH17 cell immune adaptation",

abstract = "At mucosal barriers, the T helper 17 (TH17) cell population plays a fundamental role in controlling tissue homeostasis. The adaptability of this population to a more pro-inflammatory or anti-inflammatory function - that is, their functional plasticity and consequently heterogeneity - primarily depends on the environment. We would like to term this process environmental immune adaptation. Interfering with TH17 cell adaptation leads to pathological consequences, including development of immune-mediated inflammatory diseases or even cancer. Several molecular mechanisms have been shown to participate in this process and recently, a better understanding of the transcriptional and metabolic profiling of TH17 cells has shed light on a new level of complexity. Here, we offer a summary on the role of TH17 cell plasticity in inflammatory diseases and cancer as well as the latest discoveries and controversies regarding the mechanisms that control the adaptability of the TH17 cell population.",

keywords = "Humans, Cell Plasticity, Neoplasms/metabolism, Adaptation, Physiological, Th17 Cells",

author = "Theodora Agalioti and Filippo Cortesi and Nicola Gagliani",

year = "2023",

month = aug,

doi = "10.1016/j.coi.2023.102333",

language = "English",

volume = "83",

pages = "102333",

}

RIS

TY - JOUR

T1 - TH17 cell immune adaptation

AU - Agalioti, Theodora

AU - Cortesi, Filippo

AU - Gagliani, Nicola

PY - 2023/8

Y1 - 2023/8

N2 - At mucosal barriers, the T helper 17 (TH17) cell population plays a fundamental role in controlling tissue homeostasis. The adaptability of this population to a more pro-inflammatory or anti-inflammatory function - that is, their functional plasticity and consequently heterogeneity - primarily depends on the environment. We would like to term this process environmental immune adaptation. Interfering with TH17 cell adaptation leads to pathological consequences, including development of immune-mediated inflammatory diseases or even cancer. Several molecular mechanisms have been shown to participate in this process and recently, a better understanding of the transcriptional and metabolic profiling of TH17 cells has shed light on a new level of complexity. Here, we offer a summary on the role of TH17 cell plasticity in inflammatory diseases and cancer as well as the latest discoveries and controversies regarding the mechanisms that control the adaptability of the TH17 cell population.

AB - At mucosal barriers, the T helper 17 (TH17) cell population plays a fundamental role in controlling tissue homeostasis. The adaptability of this population to a more pro-inflammatory or anti-inflammatory function - that is, their functional plasticity and consequently heterogeneity - primarily depends on the environment. We would like to term this process environmental immune adaptation. Interfering with TH17 cell adaptation leads to pathological consequences, including development of immune-mediated inflammatory diseases or even cancer. Several molecular mechanisms have been shown to participate in this process and recently, a better understanding of the transcriptional and metabolic profiling of TH17 cells has shed light on a new level of complexity. Here, we offer a summary on the role of TH17 cell plasticity in inflammatory diseases and cancer as well as the latest discoveries and controversies regarding the mechanisms that control the adaptability of the TH17 cell population.

KW - Humans

KW - Cell Plasticity

KW - Neoplasms/metabolism

KW - Adaptation, Physiological

KW - Th17 Cells

U2 - 10.1016/j.coi.2023.102333

DO - 10.1016/j.coi.2023.102333

M3 - SCORING: Review article

C2 - 37172412

VL - 83

SP - 102333

ER -