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TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

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TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer. / Perez, Laura Garcia; Kempski, Jan; M McGee, Heather; Pelzcar, Penelope; Agalioti, Theodora; Giannou, Anastasios; Konczalla, Leonie; Brockmann, Leonie; Wahib, Ramez; Xu, Hao; Vesely, Maria Carolina Amezcua; Soukou, Shiwa; Steglich, Babett; Bedke, Tanja; Manthey, Carolin; Seiz, Oliver; Diercks, Björn-Philipp; Gnafakis, Stylianos; Guse, Andreas H; Perez, Daniel; Izbicki, Jakob R; Gagliani, Nicola; Flavell, Richard A; Huber, Samuel.

In: NAT COMMUN, Vol. 11, No. 1, 25.05.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Perez, LG, Kempski, J, M McGee, H, Pelzcar, P, Agalioti, T, Giannou, A, Konczalla, L, Brockmann, L, Wahib, R, Xu, H, Vesely, MCA, Soukou, S, Steglich, B, Bedke, T, Manthey, C, Seiz, O, Diercks, B-P, Gnafakis, S, Guse, AH, Perez, D, Izbicki, JR, Gagliani, N, Flavell, RA & Huber, S 2020, 'TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer', NAT COMMUN, vol. 11, no. 1. https://doi.org/10.1038/s41467-020-16363-w

APA

Perez, L. G., Kempski, J., M McGee, H., Pelzcar, P., Agalioti, T., Giannou, A., Konczalla, L., Brockmann, L., Wahib, R., Xu, H., Vesely, M. C. A., Soukou, S., Steglich, B., Bedke, T., Manthey, C., Seiz, O., Diercks, B-P., Gnafakis, S., Guse, A. H., ... Huber, S. (2020). TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer. NAT COMMUN, 11(1). https://doi.org/10.1038/s41467-020-16363-w

Vancouver

Perez LG, Kempski J, M McGee H, Pelzcar P, Agalioti T, Giannou A et al. TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer. NAT COMMUN. 2020 May 25;11(1). https://doi.org/10.1038/s41467-020-16363-w

Bibtex

@article{14a57a9ee1894e7fa98eebc1970d6d51,
title = "TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer",
abstract = "IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major source of IL-22, but the effect of TGF-β signaling on the production of IL-22 in CD4+ T cells is controversial. Here we show an increased presence of IL-17+IL-22+ cells and TGF-β1 in colorectal cancer compared to normal adjacent tissue, whereas the frequency of IL-22 single producing cells is not changed. Accordingly, TGF-β signaling in CD4+ T cells (specifically Th17 cells) promotes the emergence of IL-22-producing Th17 cells and thereby tumorigenesis in mice. IL-22 single producing T cells, however, are not dependent on TGF-β signaling. We show that TGF-β, via AhR induction, and PI3K signaling promotes IL-22 production in Th17 cells.",
author = "Perez, {Laura Garcia} and Jan Kempski and {M McGee}, Heather and Penelope Pelzcar and Theodora Agalioti and Anastasios Giannou and Leonie Konczalla and Leonie Brockmann and Ramez Wahib and Hao Xu and Vesely, {Maria Carolina Amezcua} and Shiwa Soukou and Babett Steglich and Tanja Bedke and Carolin Manthey and Oliver Seiz and Bj{\"o}rn-Philipp Diercks and Stylianos Gnafakis and Guse, {Andreas H} and Daniel Perez and Izbicki, {Jakob R} and Nicola Gagliani and Flavell, {Richard A} and Samuel Huber",
year = "2020",
month = may,
day = "25",
doi = "10.1038/s41467-020-16363-w",
language = "English",
volume = "11",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

AU - Perez, Laura Garcia

AU - Kempski, Jan

AU - M McGee, Heather

AU - Pelzcar, Penelope

AU - Agalioti, Theodora

AU - Giannou, Anastasios

AU - Konczalla, Leonie

AU - Brockmann, Leonie

AU - Wahib, Ramez

AU - Xu, Hao

AU - Vesely, Maria Carolina Amezcua

AU - Soukou, Shiwa

AU - Steglich, Babett

AU - Bedke, Tanja

AU - Manthey, Carolin

AU - Seiz, Oliver

AU - Diercks, Björn-Philipp

AU - Gnafakis, Stylianos

AU - Guse, Andreas H

AU - Perez, Daniel

AU - Izbicki, Jakob R

AU - Gagliani, Nicola

AU - Flavell, Richard A

AU - Huber, Samuel

PY - 2020/5/25

Y1 - 2020/5/25

N2 - IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major source of IL-22, but the effect of TGF-β signaling on the production of IL-22 in CD4+ T cells is controversial. Here we show an increased presence of IL-17+IL-22+ cells and TGF-β1 in colorectal cancer compared to normal adjacent tissue, whereas the frequency of IL-22 single producing cells is not changed. Accordingly, TGF-β signaling in CD4+ T cells (specifically Th17 cells) promotes the emergence of IL-22-producing Th17 cells and thereby tumorigenesis in mice. IL-22 single producing T cells, however, are not dependent on TGF-β signaling. We show that TGF-β, via AhR induction, and PI3K signaling promotes IL-22 production in Th17 cells.

AB - IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major source of IL-22, but the effect of TGF-β signaling on the production of IL-22 in CD4+ T cells is controversial. Here we show an increased presence of IL-17+IL-22+ cells and TGF-β1 in colorectal cancer compared to normal adjacent tissue, whereas the frequency of IL-22 single producing cells is not changed. Accordingly, TGF-β signaling in CD4+ T cells (specifically Th17 cells) promotes the emergence of IL-22-producing Th17 cells and thereby tumorigenesis in mice. IL-22 single producing T cells, however, are not dependent on TGF-β signaling. We show that TGF-β, via AhR induction, and PI3K signaling promotes IL-22 production in Th17 cells.

U2 - 10.1038/s41467-020-16363-w

DO - 10.1038/s41467-020-16363-w

M3 - SCORING: Journal article

C2 - 32451418

VL - 11

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -