Termination rates and histological reclassification of active surveillance patients with low- and early intermediate-risk prostate cancer: results of the PREFERE trial

Standard

Termination rates and histological reclassification of active surveillance patients with low- and early intermediate-risk prostate cancer: results of the PREFERE trial. / Albers, Peter; Wiegel, Thomas; Schmidberger, Heinz; Bussar-Maatz, Roswitha; Härter, Martin; Kristiansen, Glen; Martus, Peter; Meisner, Christoph; Wellek, Stefan; Grozinger, Klaus; Renner, Peter; Burmester, Martin; Schneider, Fried; Stöckle, Michael.

In: WORLD J UROL, Vol. 39, No. 1, 01.2021, p. 65-72.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

Harvard

Albers, P, Wiegel, T, Schmidberger, H, Bussar-Maatz, R, Härter, M, Kristiansen, G, Martus, P, Meisner, C, Wellek, S, Grozinger, K, Renner, P, Burmester, M, Schneider, F & Stöckle, M 2021, 'Termination rates and histological reclassification of active surveillance patients with low- and early intermediate-risk prostate cancer: results of the PREFERE trial', WORLD J UROL, vol. 39, no. 1, pp. 65-72. https://doi.org/10.1007/s00345-020-03154-7

APA

Albers, P., Wiegel, T., Schmidberger, H., Bussar-Maatz, R., Härter, M., Kristiansen, G., Martus, P., Meisner, C., Wellek, S., Grozinger, K., Renner, P., Burmester, M., Schneider, F., & Stöckle, M. (2021). Termination rates and histological reclassification of active surveillance patients with low- and early intermediate-risk prostate cancer: results of the PREFERE trial. WORLD J UROL, 39(1), 65-72. https://doi.org/10.1007/s00345-020-03154-7

Vancouver

Bibtex

@article{a9ae3e2c043446fc90f13046bdc0f10a,
title = "Termination rates and histological reclassification of active surveillance patients with low- and early intermediate-risk prostate cancer: results of the PREFERE trial",
abstract = "PURPOSE: Active surveillance (AS) strategies for patients with low- and early intermediate-risk prostate cancer are still not consistently defined. Within a controlled randomized trial, active surveillance was compared to other treatment options for patients with prostate cancer. Aim of this analysis was to report on termination rates of patients treated with AS including different grade groups.METHODS: A randomized trial comparing radical prostatectomy, active surveillance, external beam radiotherapy and brachytherapy was performed from 2013 to 2016 and included 345 patients with low- and early intermediate-risk prostate cancer (ISUP grade groups 1 and 2). The trial was prematurely stopped due to slow accrual. A total of 130 patients were treated with active surveillance. Among them, 42 patients were diagnosed with intermediate-risk PCA. Reference pathology and AS quality control were performed throughout.RESULTS: After a median follow-up time of 18.8 months, 73 out of the 130 patients (56%) terminated active surveillance. Of these, 56 (77%) patients were histologically reclassified at the time of rebiopsy, including 35% and 60% of the grade group 1 and 2 patients, respectively. No patients who underwent radical prostatectomy at the time of reclassification had radical prostatectomy specimens ≥ grade group 3.CONCLUSION: In this prospectively analyzed subcohort of patients with AS and conventional staging within a randomized trial, the 2-year histological reclassification rates were higher than those previously reported. Active surveillance may not be based on conventional staging alone, and patients with grade group 2 cancers may be recommended for active surveillance in carefully controlled trials only.",
author = "Peter Albers and Thomas Wiegel and Heinz Schmidberger and Roswitha Bussar-Maatz and Martin H{\"a}rter and Glen Kristiansen and Peter Martus and Christoph Meisner and Stefan Wellek and Klaus Grozinger and Peter Renner and Martin Burmester and Fried Schneider and Michael St{\"o}ckle",
year = "2021",
month = jan,
doi = "10.1007/s00345-020-03154-7",
language = "English",
volume = "39",
pages = "65--72",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Termination rates and histological reclassification of active surveillance patients with low- and early intermediate-risk prostate cancer: results of the PREFERE trial

AU - Albers, Peter

AU - Wiegel, Thomas

AU - Schmidberger, Heinz

AU - Bussar-Maatz, Roswitha

AU - Härter, Martin

AU - Kristiansen, Glen

AU - Martus, Peter

AU - Meisner, Christoph

AU - Wellek, Stefan

AU - Grozinger, Klaus

AU - Renner, Peter

AU - Burmester, Martin

AU - Schneider, Fried

AU - Stöckle, Michael

PY - 2021/1

Y1 - 2021/1

N2 - PURPOSE: Active surveillance (AS) strategies for patients with low- and early intermediate-risk prostate cancer are still not consistently defined. Within a controlled randomized trial, active surveillance was compared to other treatment options for patients with prostate cancer. Aim of this analysis was to report on termination rates of patients treated with AS including different grade groups.METHODS: A randomized trial comparing radical prostatectomy, active surveillance, external beam radiotherapy and brachytherapy was performed from 2013 to 2016 and included 345 patients with low- and early intermediate-risk prostate cancer (ISUP grade groups 1 and 2). The trial was prematurely stopped due to slow accrual. A total of 130 patients were treated with active surveillance. Among them, 42 patients were diagnosed with intermediate-risk PCA. Reference pathology and AS quality control were performed throughout.RESULTS: After a median follow-up time of 18.8 months, 73 out of the 130 patients (56%) terminated active surveillance. Of these, 56 (77%) patients were histologically reclassified at the time of rebiopsy, including 35% and 60% of the grade group 1 and 2 patients, respectively. No patients who underwent radical prostatectomy at the time of reclassification had radical prostatectomy specimens ≥ grade group 3.CONCLUSION: In this prospectively analyzed subcohort of patients with AS and conventional staging within a randomized trial, the 2-year histological reclassification rates were higher than those previously reported. Active surveillance may not be based on conventional staging alone, and patients with grade group 2 cancers may be recommended for active surveillance in carefully controlled trials only.

AB - PURPOSE: Active surveillance (AS) strategies for patients with low- and early intermediate-risk prostate cancer are still not consistently defined. Within a controlled randomized trial, active surveillance was compared to other treatment options for patients with prostate cancer. Aim of this analysis was to report on termination rates of patients treated with AS including different grade groups.METHODS: A randomized trial comparing radical prostatectomy, active surveillance, external beam radiotherapy and brachytherapy was performed from 2013 to 2016 and included 345 patients with low- and early intermediate-risk prostate cancer (ISUP grade groups 1 and 2). The trial was prematurely stopped due to slow accrual. A total of 130 patients were treated with active surveillance. Among them, 42 patients were diagnosed with intermediate-risk PCA. Reference pathology and AS quality control were performed throughout.RESULTS: After a median follow-up time of 18.8 months, 73 out of the 130 patients (56%) terminated active surveillance. Of these, 56 (77%) patients were histologically reclassified at the time of rebiopsy, including 35% and 60% of the grade group 1 and 2 patients, respectively. No patients who underwent radical prostatectomy at the time of reclassification had radical prostatectomy specimens ≥ grade group 3.CONCLUSION: In this prospectively analyzed subcohort of patients with AS and conventional staging within a randomized trial, the 2-year histological reclassification rates were higher than those previously reported. Active surveillance may not be based on conventional staging alone, and patients with grade group 2 cancers may be recommended for active surveillance in carefully controlled trials only.

U2 - 10.1007/s00345-020-03154-7

DO - 10.1007/s00345-020-03154-7

M3 - SCORING: Journal article

C2 - 32189088

VL - 39

SP - 65

EP - 72

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 1

ER -