Tenascin demarcates the boundary between the myelinated and nonmyelinated part of retinal ganglion cell axons in the developing and adult mouse
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Tenascin demarcates the boundary between the myelinated and nonmyelinated part of retinal ganglion cell axons in the developing and adult mouse. / Bartsch, U; Faissner, A; Trotter, J; Dörries, U; Bartsch, S; Mohajeri, H; Schachner, M.
In: J NEUROSCI, Vol. 14, No. 8, 08.1994, p. 4756-68.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Tenascin demarcates the boundary between the myelinated and nonmyelinated part of retinal ganglion cell axons in the developing and adult mouse
AU - Bartsch, U
AU - Faissner, A
AU - Trotter, J
AU - Dörries, U
AU - Bartsch, S
AU - Mohajeri, H
AU - Schachner, M
PY - 1994/8
Y1 - 1994/8
N2 - The molecular determinants controlling the topographically restricted distribution of neural cells in the mammalian CNS are largely unknown. In the mouse, myelin-forming oligodendrocytes are differentially distributed along retinal ganglion cell axons. These axons are myelin free intraretinally and in the most proximal (i.e., retinal) part of the optic nerve, but become myelinated in the distal (i.e., chiasmal) part of the optic nerve. Tenascin protein and mRNA are detectable in increased amounts at the retinal end of the developing optic nerve before the arrival of oligodendrocyte progenitor cells and are restricted to this region in the adult optic nerve. Tenascin is a nonadhesive substrate for oligodendrocytes and their progenitor cells in vitro when offered as a substrate in choice with polyornithine. These observations suggest that tenascin is critical for the establishment and maintenance of the restricted distribution of myelin-forming oligodendrocytes along retinal ganglion cell axons of the mouse.
AB - The molecular determinants controlling the topographically restricted distribution of neural cells in the mammalian CNS are largely unknown. In the mouse, myelin-forming oligodendrocytes are differentially distributed along retinal ganglion cell axons. These axons are myelin free intraretinally and in the most proximal (i.e., retinal) part of the optic nerve, but become myelinated in the distal (i.e., chiasmal) part of the optic nerve. Tenascin protein and mRNA are detectable in increased amounts at the retinal end of the developing optic nerve before the arrival of oligodendrocyte progenitor cells and are restricted to this region in the adult optic nerve. Tenascin is a nonadhesive substrate for oligodendrocytes and their progenitor cells in vitro when offered as a substrate in choice with polyornithine. These observations suggest that tenascin is critical for the establishment and maintenance of the restricted distribution of myelin-forming oligodendrocytes along retinal ganglion cell axons of the mouse.
KW - Animals
KW - Axons
KW - Cell Adhesion Molecules, Neuronal
KW - Cells, Cultured
KW - Extracellular Matrix Proteins
KW - Fluorescent Antibody Technique
KW - Glial Fibrillary Acidic Protein
KW - In Situ Hybridization
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Inbred ICR
KW - Microscopy, Immunoelectron
KW - Nerve Fibers, Myelinated
KW - Nerve Tissue Proteins
KW - Oligodendroglia
KW - Optic Nerve
KW - RNA, Messenger
KW - Receptors, Platelet-Derived Growth Factor
KW - Retinal Ganglion Cells
KW - Stem Cells
KW - Tenascin
KW - Journal Article
M3 - SCORING: Journal article
C2 - 7519256
VL - 14
SP - 4756
EP - 4768
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 8
ER -