Temporal trends in incidence, causes, use of mechanical circulatory support and mortality in cardiogenic shock

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@article{d498d68831b7420d9a01f9314837dc87,
title = "Temporal trends in incidence, causes, use of mechanical circulatory support and mortality in cardiogenic shock",
abstract = "AIM: The management of cardiogenic shock remains a clinical challenge even in well-developed healthcare systems, best illustrated by its high mortality despite numerous innovative proposals for management. The aim of this study was to describe temporal trends in incidence, causes, use of mechanical circulatory support, and mortality in cardiogenic shock in Germany.METHODS AND RESULTS: Data on all cardiogenic shock patients treated in German hospitals between 2005 and 2017 were obtained from the Federal Bureau of Statistics. The data set comprised 441 696 patients with cardiogenic shock, mean age 71 (±13.8) years, 171 383 (39%) female patients. Incidence rates increased from 33.1/100 000 population in 2005 (27 246 cases) to 51.7/100 000 population in 2017 (42 779 cases). Acute myocardial infarction was the most common cause of cardiogenic shock in 2005-07 (43 422 of 82 037 cases, 52.9%), but the proportion of cases caused by it decreased until 2014-17 (73 274 of 165 873 cases, 44.2%). Over time, intra-aortic balloon pump (2005: 5104; 2017: 973 cases) was used less frequently, whereas use of extracorporeal-membrane-oxygenation (2007: 35; 2017: 2414 cases) and percutaneous left ventricular assist devices (2005: 27; 2017: 1323 cases) increased. Mortality remained high at around 60% without relevant temporal trends in patients without acute myocardial infarction and slightly decreased in patients with acute myocardial infarction.CONCLUSIONS: In this large, nation-wide study, annual incidence of cardiogenic shock was growing, its causes were changing, and mortality was high despite a shift towards use of novel mechanical circulatory support devices. This highlights the need to address the evidence gap in this field, in particular for cardiogenic shock caused by diseases other than acute myocardial infarction.",
author = "Benedikt Schrage and Becher, {Peter Moritz} and Alina Go{\ss}ling and Gianluigi Savarese and Salim Dabboura and Isabell Yan and Benedikt Beer and Gerold S{\"o}ffker and Moritz Seiffert and Stefan Kluge and Paulus Kirchhof and Stefan Blankenberg and Dirk Westermann",
note = "{\textcopyright} 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.",
year = "2021",
month = apr,
doi = "10.1002/ehf2.13202",
language = "English",
volume = "8",
pages = "1295--1303",
journal = "ESC HEART FAIL",
issn = "2055-5822",
publisher = "The Heart Failure Association of the European Society of Cardiology",
number = "2",

}

RIS

TY - JOUR

T1 - Temporal trends in incidence, causes, use of mechanical circulatory support and mortality in cardiogenic shock

AU - Schrage, Benedikt

AU - Becher, Peter Moritz

AU - Goßling, Alina

AU - Savarese, Gianluigi

AU - Dabboura, Salim

AU - Yan, Isabell

AU - Beer, Benedikt

AU - Söffker, Gerold

AU - Seiffert, Moritz

AU - Kluge, Stefan

AU - Kirchhof, Paulus

AU - Blankenberg, Stefan

AU - Westermann, Dirk

N1 - © 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

PY - 2021/4

Y1 - 2021/4

N2 - AIM: The management of cardiogenic shock remains a clinical challenge even in well-developed healthcare systems, best illustrated by its high mortality despite numerous innovative proposals for management. The aim of this study was to describe temporal trends in incidence, causes, use of mechanical circulatory support, and mortality in cardiogenic shock in Germany.METHODS AND RESULTS: Data on all cardiogenic shock patients treated in German hospitals between 2005 and 2017 were obtained from the Federal Bureau of Statistics. The data set comprised 441 696 patients with cardiogenic shock, mean age 71 (±13.8) years, 171 383 (39%) female patients. Incidence rates increased from 33.1/100 000 population in 2005 (27 246 cases) to 51.7/100 000 population in 2017 (42 779 cases). Acute myocardial infarction was the most common cause of cardiogenic shock in 2005-07 (43 422 of 82 037 cases, 52.9%), but the proportion of cases caused by it decreased until 2014-17 (73 274 of 165 873 cases, 44.2%). Over time, intra-aortic balloon pump (2005: 5104; 2017: 973 cases) was used less frequently, whereas use of extracorporeal-membrane-oxygenation (2007: 35; 2017: 2414 cases) and percutaneous left ventricular assist devices (2005: 27; 2017: 1323 cases) increased. Mortality remained high at around 60% without relevant temporal trends in patients without acute myocardial infarction and slightly decreased in patients with acute myocardial infarction.CONCLUSIONS: In this large, nation-wide study, annual incidence of cardiogenic shock was growing, its causes were changing, and mortality was high despite a shift towards use of novel mechanical circulatory support devices. This highlights the need to address the evidence gap in this field, in particular for cardiogenic shock caused by diseases other than acute myocardial infarction.

AB - AIM: The management of cardiogenic shock remains a clinical challenge even in well-developed healthcare systems, best illustrated by its high mortality despite numerous innovative proposals for management. The aim of this study was to describe temporal trends in incidence, causes, use of mechanical circulatory support, and mortality in cardiogenic shock in Germany.METHODS AND RESULTS: Data on all cardiogenic shock patients treated in German hospitals between 2005 and 2017 were obtained from the Federal Bureau of Statistics. The data set comprised 441 696 patients with cardiogenic shock, mean age 71 (±13.8) years, 171 383 (39%) female patients. Incidence rates increased from 33.1/100 000 population in 2005 (27 246 cases) to 51.7/100 000 population in 2017 (42 779 cases). Acute myocardial infarction was the most common cause of cardiogenic shock in 2005-07 (43 422 of 82 037 cases, 52.9%), but the proportion of cases caused by it decreased until 2014-17 (73 274 of 165 873 cases, 44.2%). Over time, intra-aortic balloon pump (2005: 5104; 2017: 973 cases) was used less frequently, whereas use of extracorporeal-membrane-oxygenation (2007: 35; 2017: 2414 cases) and percutaneous left ventricular assist devices (2005: 27; 2017: 1323 cases) increased. Mortality remained high at around 60% without relevant temporal trends in patients without acute myocardial infarction and slightly decreased in patients with acute myocardial infarction.CONCLUSIONS: In this large, nation-wide study, annual incidence of cardiogenic shock was growing, its causes were changing, and mortality was high despite a shift towards use of novel mechanical circulatory support devices. This highlights the need to address the evidence gap in this field, in particular for cardiogenic shock caused by diseases other than acute myocardial infarction.

U2 - 10.1002/ehf2.13202

DO - 10.1002/ehf2.13202

M3 - SCORING: Journal article

C2 - 33605565

VL - 8

SP - 1295

EP - 1303

JO - ESC HEART FAIL

JF - ESC HEART FAIL

SN - 2055-5822

IS - 2

ER -