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Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection

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Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection. / Vaidya, Sagar A; Streeck, Hendrik; Beckwith, Noor; Ghebremichael, Musie; Pereyra, Florencia; Kwon, Douglas S; Addo, Marylyn Martina; Rychert, Jenna; Routy, Jean-Pierre; Jessen, Heiko; Kelleher, Anthony D; Hecht, Frederick; Sekaly, Rafick-Pierre; Carrington, Mary; Walker, Bruce D; Allen, Todd M; Rosenberg, Eric S; Altfeld, Marcus.

In: RETROVIROLOGY, Vol. 10, 01.01.2013, p. 139.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Vaidya, SA, Streeck, H, Beckwith, N, Ghebremichael, M, Pereyra, F, Kwon, DS, Addo, MM, Rychert, J, Routy, J-P, Jessen, H, Kelleher, AD, Hecht, F, Sekaly, R-P, Carrington, M, Walker, BD, Allen, TM, Rosenberg, ES & Altfeld, M 2013, 'Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection', RETROVIROLOGY, vol. 10, pp. 139. https://doi.org/10.1186/1742-4690-10-139

APA

Vaidya, S. A., Streeck, H., Beckwith, N., Ghebremichael, M., Pereyra, F., Kwon, D. S., Addo, M. M., Rychert, J., Routy, J-P., Jessen, H., Kelleher, A. D., Hecht, F., Sekaly, R-P., Carrington, M., Walker, B. D., Allen, T. M., Rosenberg, E. S., & Altfeld, M. (2013). Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection. RETROVIROLOGY, 10, 139. https://doi.org/10.1186/1742-4690-10-139

Vancouver

Vaidya SA, Streeck H, Beckwith N, Ghebremichael M, Pereyra F, Kwon DS et al. Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection. RETROVIROLOGY. 2013 Jan 1;10:139. https://doi.org/10.1186/1742-4690-10-139

Bibtex

@article{914eac7d884149398dd93cbdbfaa3721,
title = "Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection",
abstract = "BACKGROUND: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, their role in primary HIV-1 disease is unclear. This study sought to determine the role of HLA-B alleles in viral control during the acute phase of HIV-1 infection and establishment of the early viral load set point (VLSP).FINDINGS: Individuals identified during primary HIV-1 infection were HLA class I typed and followed longitudinally. Associations between HLA-B alleles and HIV-1 viral replication during acute infection and VLSP were analyzed in untreated subjects. The results showed that neither HLA-B*57 nor HLA-B*27 were significantly associated with viral control during acute HIV-1 infection (Fiebig stage I-IV, n=171). HLA-B*57 was however significantly associated with a subsequent lower VLSP (p<0.001, n=135) with nearly 1 log10 less median viral load. Analysis of a known polymorphism at position 97 of HLA-B showed significant associations with both lower initial viral load (p<0.01) and lower VLSP (p<0.05). However, this association was dependent on different amino acids at this position for each endpoint.CONCLUSIONS: The effect of HLA-B*57 on viral control is more pronounced during the later stages of primary HIV-1 infection, which suggests the underlying mechanism of control occurs at a critical period in the first several months after HIV-1 acquisition. The risk profile of polymorphisms at position 97 of HLA-B are more broadly associated with HIV-1 viral load during primary infection and may serve as a focal point in further studies of HLA-B function.",
author = "Vaidya, {Sagar A} and Hendrik Streeck and Noor Beckwith and Musie Ghebremichael and Florencia Pereyra and Kwon, {Douglas S} and Addo, {Marylyn Martina} and Jenna Rychert and Jean-Pierre Routy and Heiko Jessen and Kelleher, {Anthony D} and Frederick Hecht and Rafick-Pierre Sekaly and Mary Carrington and Walker, {Bruce D} and Allen, {Todd M} and Rosenberg, {Eric S} and Marcus Altfeld",
year = "2013",
month = jan,
day = "1",
doi = "10.1186/1742-4690-10-139",
language = "English",
volume = "10",
pages = "139",
journal = "RETROVIROLOGY",
issn = "1742-4690",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection

AU - Vaidya, Sagar A

AU - Streeck, Hendrik

AU - Beckwith, Noor

AU - Ghebremichael, Musie

AU - Pereyra, Florencia

AU - Kwon, Douglas S

AU - Addo, Marylyn Martina

AU - Rychert, Jenna

AU - Routy, Jean-Pierre

AU - Jessen, Heiko

AU - Kelleher, Anthony D

AU - Hecht, Frederick

AU - Sekaly, Rafick-Pierre

AU - Carrington, Mary

AU - Walker, Bruce D

AU - Allen, Todd M

AU - Rosenberg, Eric S

AU - Altfeld, Marcus

PY - 2013/1/1

Y1 - 2013/1/1

N2 - BACKGROUND: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, their role in primary HIV-1 disease is unclear. This study sought to determine the role of HLA-B alleles in viral control during the acute phase of HIV-1 infection and establishment of the early viral load set point (VLSP).FINDINGS: Individuals identified during primary HIV-1 infection were HLA class I typed and followed longitudinally. Associations between HLA-B alleles and HIV-1 viral replication during acute infection and VLSP were analyzed in untreated subjects. The results showed that neither HLA-B*57 nor HLA-B*27 were significantly associated with viral control during acute HIV-1 infection (Fiebig stage I-IV, n=171). HLA-B*57 was however significantly associated with a subsequent lower VLSP (p<0.001, n=135) with nearly 1 log10 less median viral load. Analysis of a known polymorphism at position 97 of HLA-B showed significant associations with both lower initial viral load (p<0.01) and lower VLSP (p<0.05). However, this association was dependent on different amino acids at this position for each endpoint.CONCLUSIONS: The effect of HLA-B*57 on viral control is more pronounced during the later stages of primary HIV-1 infection, which suggests the underlying mechanism of control occurs at a critical period in the first several months after HIV-1 acquisition. The risk profile of polymorphisms at position 97 of HLA-B are more broadly associated with HIV-1 viral load during primary infection and may serve as a focal point in further studies of HLA-B function.

AB - BACKGROUND: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, their role in primary HIV-1 disease is unclear. This study sought to determine the role of HLA-B alleles in viral control during the acute phase of HIV-1 infection and establishment of the early viral load set point (VLSP).FINDINGS: Individuals identified during primary HIV-1 infection were HLA class I typed and followed longitudinally. Associations between HLA-B alleles and HIV-1 viral replication during acute infection and VLSP were analyzed in untreated subjects. The results showed that neither HLA-B*57 nor HLA-B*27 were significantly associated with viral control during acute HIV-1 infection (Fiebig stage I-IV, n=171). HLA-B*57 was however significantly associated with a subsequent lower VLSP (p<0.001, n=135) with nearly 1 log10 less median viral load. Analysis of a known polymorphism at position 97 of HLA-B showed significant associations with both lower initial viral load (p<0.01) and lower VLSP (p<0.05). However, this association was dependent on different amino acids at this position for each endpoint.CONCLUSIONS: The effect of HLA-B*57 on viral control is more pronounced during the later stages of primary HIV-1 infection, which suggests the underlying mechanism of control occurs at a critical period in the first several months after HIV-1 acquisition. The risk profile of polymorphisms at position 97 of HLA-B are more broadly associated with HIV-1 viral load during primary infection and may serve as a focal point in further studies of HLA-B function.

U2 - 10.1186/1742-4690-10-139

DO - 10.1186/1742-4690-10-139

M3 - SCORING: Journal article

C2 - 24245727

VL - 10

SP - 139

JO - RETROVIROLOGY

JF - RETROVIROLOGY

SN - 1742-4690

ER -