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Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration

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Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration. / Gomez-Nicola, Diego; Suzzi, Stefano; Vargas-Caballero, Mariana; Fransen, Nina L; Al-Malki, Hussain; Cebrian-Silla, Arantxa; Garcia-Verdugo, Jose Manuel; Riecken, Kristoffer; Fehse, Boris; Perry, V Hugh.

In: BRAIN, Vol. 137, No. Pt 8, 01.08.2014, p. 2312-28.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gomez-Nicola, D, Suzzi, S, Vargas-Caballero, M, Fransen, NL, Al-Malki, H, Cebrian-Silla, A, Garcia-Verdugo, JM, Riecken, K, Fehse, B & Perry, VH 2014, 'Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration', BRAIN, vol. 137, no. Pt 8, pp. 2312-28. https://doi.org/10.1093/brain/awu155

APA

Gomez-Nicola, D., Suzzi, S., Vargas-Caballero, M., Fransen, N. L., Al-Malki, H., Cebrian-Silla, A., Garcia-Verdugo, J. M., Riecken, K., Fehse, B., & Perry, V. H. (2014). Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration. BRAIN, 137(Pt 8), 2312-28. https://doi.org/10.1093/brain/awu155

Vancouver

Gomez-Nicola D, Suzzi S, Vargas-Caballero M, Fransen NL, Al-Malki H, Cebrian-Silla A et al. Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration. BRAIN. 2014 Aug 1;137(Pt 8):2312-28. https://doi.org/10.1093/brain/awu155

Bibtex

@article{31819a3e5e544e909421c094d2a08d86,
title = "Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration",
abstract = "The study of neurogenesis during chronic neurodegeneration is crucial in order to understand the intrinsic repair mechanisms of the brain, and key to designing therapeutic strategies. In this study, using an experimental model of progressive chronic neurodegeneration, murine prion disease, we define the temporal dynamics of the generation, maturation and integration of new neurons in the hippocampal dentate gyrus, using dual pulse-chase, multicolour γ-retroviral tracing, transmission electron microscopy and patch-clamp. We found increased neurogenesis during the progression of prion disease, which partially counteracts the effects of chronic neurodegeneration, as evidenced by blocking neurogenesis with cytosine arabinoside, and helps to preserve the hippocampal function. Evidence obtained from human post-mortem samples, of both variant Creutzfeldt-Jakob disease and Alzheimer's disease patients, also suggests increased neurogenic activity. These results open a new avenue into the exploration of the effects and regulation of neurogenesis during chronic neurodegeneration, and offer a new model to reproduce the changes observed in human neurodegenerative diseases.",
author = "Diego Gomez-Nicola and Stefano Suzzi and Mariana Vargas-Caballero and Fransen, {Nina L} and Hussain Al-Malki and Arantxa Cebrian-Silla and Garcia-Verdugo, {Jose Manuel} and Kristoffer Riecken and Boris Fehse and Perry, {V Hugh}",
note = "{\textcopyright} The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain.",
year = "2014",
month = aug,
day = "1",
doi = "10.1093/brain/awu155",
language = "English",
volume = "137",
pages = "2312--28",
journal = "BRAIN",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "Pt 8",

}

RIS

TY - JOUR

T1 - Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration

AU - Gomez-Nicola, Diego

AU - Suzzi, Stefano

AU - Vargas-Caballero, Mariana

AU - Fransen, Nina L

AU - Al-Malki, Hussain

AU - Cebrian-Silla, Arantxa

AU - Garcia-Verdugo, Jose Manuel

AU - Riecken, Kristoffer

AU - Fehse, Boris

AU - Perry, V Hugh

N1 - © The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain.

PY - 2014/8/1

Y1 - 2014/8/1

N2 - The study of neurogenesis during chronic neurodegeneration is crucial in order to understand the intrinsic repair mechanisms of the brain, and key to designing therapeutic strategies. In this study, using an experimental model of progressive chronic neurodegeneration, murine prion disease, we define the temporal dynamics of the generation, maturation and integration of new neurons in the hippocampal dentate gyrus, using dual pulse-chase, multicolour γ-retroviral tracing, transmission electron microscopy and patch-clamp. We found increased neurogenesis during the progression of prion disease, which partially counteracts the effects of chronic neurodegeneration, as evidenced by blocking neurogenesis with cytosine arabinoside, and helps to preserve the hippocampal function. Evidence obtained from human post-mortem samples, of both variant Creutzfeldt-Jakob disease and Alzheimer's disease patients, also suggests increased neurogenic activity. These results open a new avenue into the exploration of the effects and regulation of neurogenesis during chronic neurodegeneration, and offer a new model to reproduce the changes observed in human neurodegenerative diseases.

AB - The study of neurogenesis during chronic neurodegeneration is crucial in order to understand the intrinsic repair mechanisms of the brain, and key to designing therapeutic strategies. In this study, using an experimental model of progressive chronic neurodegeneration, murine prion disease, we define the temporal dynamics of the generation, maturation and integration of new neurons in the hippocampal dentate gyrus, using dual pulse-chase, multicolour γ-retroviral tracing, transmission electron microscopy and patch-clamp. We found increased neurogenesis during the progression of prion disease, which partially counteracts the effects of chronic neurodegeneration, as evidenced by blocking neurogenesis with cytosine arabinoside, and helps to preserve the hippocampal function. Evidence obtained from human post-mortem samples, of both variant Creutzfeldt-Jakob disease and Alzheimer's disease patients, also suggests increased neurogenic activity. These results open a new avenue into the exploration of the effects and regulation of neurogenesis during chronic neurodegeneration, and offer a new model to reproduce the changes observed in human neurodegenerative diseases.

U2 - 10.1093/brain/awu155

DO - 10.1093/brain/awu155

M3 - SCORING: Journal article

C2 - 24941947

VL - 137

SP - 2312

EP - 2328

JO - BRAIN

JF - BRAIN

SN - 0006-8950

IS - Pt 8

ER -