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Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro

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Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro. / Luckert, Christian; Eschenburg, Georg; Roth, Beate; Appl, Birgit; Reinshagen, Konrad; Bergholz, Robert.

In: J PEDIAT HEMATOL ONC, Vol. 36, No. 4, 01.05.2014, p. e219-23.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Luckert, C, Eschenburg, G, Roth, B, Appl, B, Reinshagen, K & Bergholz, R 2014, 'Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro', J PEDIAT HEMATOL ONC, vol. 36, no. 4, pp. e219-23. https://doi.org/10.1097/MPH.0000000000000149

APA

Luckert, C., Eschenburg, G., Roth, B., Appl, B., Reinshagen, K., & Bergholz, R. (2014). Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro. J PEDIAT HEMATOL ONC, 36(4), e219-23. https://doi.org/10.1097/MPH.0000000000000149

Vancouver

Luckert C, Eschenburg G, Roth B, Appl B, Reinshagen K, Bergholz R. Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro. J PEDIAT HEMATOL ONC. 2014 May 1;36(4):e219-23. https://doi.org/10.1097/MPH.0000000000000149

Bibtex

@article{dd0bd813704b41e299bfab0e6024c5f0,
title = "Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro",
abstract = "BACKGROUND: Neuroblastoma is a common pediatric solid tumor with poor outcome for metastatic disease. Thus, novel therapeutic options are of main interest. The anti-neoplastic properties of taurolidine have been demonstrated on a variety of human cancer cells. However, data on neuroblastoma is lacking. Therefore, our aim was to evaluate the effect of taurolidine on growth of neuroblastoma cell lines.MATERIALS AND METHODS: Neuroblastoma SK-N-BE(2)-M17 and SK-N-SH cells and nonmalignant human umbilical vein endothelial cells as controls were incubated with increasing concentrations of taurolidine (100, 250, 500 µM). Cell growth was examined after 12, 24, and 48 hours of exposure.RESULTS: Inhibition of cell growth by taurolidine was seen in both malignant cell lines. When compared with human umbilical vein endothelial cells, the neuroblastoma cell lines were significantly more responsive to taurolidine.CONCLUSIONS: The observed negative impact on cell growth, highly distinctive in SK-N-BE(2)-M17 and SK-N-SH, implies a taurolidine-specific mode of action that appears dependent on differences on cellular and molecular level. Further investigations are warranted to evaluate its mechanism and probable clinical use.",
author = "Christian Luckert and Georg Eschenburg and Beate Roth and Birgit Appl and Konrad Reinshagen and Robert Bergholz",
year = "2014",
month = may,
day = "1",
doi = "10.1097/MPH.0000000000000149",
language = "English",
volume = "36",
pages = "e219--23",
journal = "J PEDIAT HEMATOL ONC",
issn = "1077-4114",
publisher = "Raven Press",
number = "4",

}

RIS

TY - JOUR

T1 - Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro

AU - Luckert, Christian

AU - Eschenburg, Georg

AU - Roth, Beate

AU - Appl, Birgit

AU - Reinshagen, Konrad

AU - Bergholz, Robert

PY - 2014/5/1

Y1 - 2014/5/1

N2 - BACKGROUND: Neuroblastoma is a common pediatric solid tumor with poor outcome for metastatic disease. Thus, novel therapeutic options are of main interest. The anti-neoplastic properties of taurolidine have been demonstrated on a variety of human cancer cells. However, data on neuroblastoma is lacking. Therefore, our aim was to evaluate the effect of taurolidine on growth of neuroblastoma cell lines.MATERIALS AND METHODS: Neuroblastoma SK-N-BE(2)-M17 and SK-N-SH cells and nonmalignant human umbilical vein endothelial cells as controls were incubated with increasing concentrations of taurolidine (100, 250, 500 µM). Cell growth was examined after 12, 24, and 48 hours of exposure.RESULTS: Inhibition of cell growth by taurolidine was seen in both malignant cell lines. When compared with human umbilical vein endothelial cells, the neuroblastoma cell lines were significantly more responsive to taurolidine.CONCLUSIONS: The observed negative impact on cell growth, highly distinctive in SK-N-BE(2)-M17 and SK-N-SH, implies a taurolidine-specific mode of action that appears dependent on differences on cellular and molecular level. Further investigations are warranted to evaluate its mechanism and probable clinical use.

AB - BACKGROUND: Neuroblastoma is a common pediatric solid tumor with poor outcome for metastatic disease. Thus, novel therapeutic options are of main interest. The anti-neoplastic properties of taurolidine have been demonstrated on a variety of human cancer cells. However, data on neuroblastoma is lacking. Therefore, our aim was to evaluate the effect of taurolidine on growth of neuroblastoma cell lines.MATERIALS AND METHODS: Neuroblastoma SK-N-BE(2)-M17 and SK-N-SH cells and nonmalignant human umbilical vein endothelial cells as controls were incubated with increasing concentrations of taurolidine (100, 250, 500 µM). Cell growth was examined after 12, 24, and 48 hours of exposure.RESULTS: Inhibition of cell growth by taurolidine was seen in both malignant cell lines. When compared with human umbilical vein endothelial cells, the neuroblastoma cell lines were significantly more responsive to taurolidine.CONCLUSIONS: The observed negative impact on cell growth, highly distinctive in SK-N-BE(2)-M17 and SK-N-SH, implies a taurolidine-specific mode of action that appears dependent on differences on cellular and molecular level. Further investigations are warranted to evaluate its mechanism and probable clinical use.

U2 - 10.1097/MPH.0000000000000149

DO - 10.1097/MPH.0000000000000149

M3 - SCORING: Journal article

C2 - 24762556

VL - 36

SP - e219-23

JO - J PEDIAT HEMATOL ONC

JF - J PEDIAT HEMATOL ONC

SN - 1077-4114

IS - 4

ER -