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Targeted Temperature Management in Spontaneous Intracerebral Hemorrhage: A Systematic Review

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Targeted Temperature Management in Spontaneous Intracerebral Hemorrhage: A Systematic Review. / Fischer, Marlene; Schiefecker, Alois; Lackner, Peter; Helbok, Raimund; Beer, Ronny; Pfausler, Bettina; Schmutzhard, Erich; Broessner, Gregor.

In: CURR DRUG TARGETS, Vol. 18, No. 12, 2017, p. 1430-1440.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Fischer, M, Schiefecker, A, Lackner, P, Helbok, R, Beer, R, Pfausler, B, Schmutzhard, E & Broessner, G 2017, 'Targeted Temperature Management in Spontaneous Intracerebral Hemorrhage: A Systematic Review', CURR DRUG TARGETS, vol. 18, no. 12, pp. 1430-1440.

APA

Fischer, M., Schiefecker, A., Lackner, P., Helbok, R., Beer, R., Pfausler, B., Schmutzhard, E., & Broessner, G. (2017). Targeted Temperature Management in Spontaneous Intracerebral Hemorrhage: A Systematic Review. CURR DRUG TARGETS, 18(12), 1430-1440.

Vancouver

Fischer M, Schiefecker A, Lackner P, Helbok R, Beer R, Pfausler B et al. Targeted Temperature Management in Spontaneous Intracerebral Hemorrhage: A Systematic Review. CURR DRUG TARGETS. 2017;18(12):1430-1440.

Bibtex

@article{dfd2eaa37d844556afd9a7d9fa57e949,
title = "Targeted Temperature Management in Spontaneous Intracerebral Hemorrhage: A Systematic Review",
abstract = "Fever is common in neurocritical care patients and is associated with poor outcome. Targeted temperature management (TTM), i.e. therapeutic hypothermia or controlled normothermia, after acute brain injury has been studied as a neuroprotectant for several decades. In contrast to pharmacological agents with specific targets TTM affects multiple pathophysiological mechanisms and is primarily thought to attenuate secondary brain injury. Most promising results have been obtained from experimental studies on cerebral ischemia or traumatic brain injury showing beneficial effects of hypothermia on structural and functional outcome. A positive influence of hypothermia has been observed in animal models of spontaneous intracerebral hemorrhage (ICH) improving, among others, perihematomal edema, blood-brain barrier integrity, inflammation and thrombin-induced injury. However, results regarding functional outcome are conflicting. Little data is available on the effect of TTM in humans. Single-center observational studies have shown reduced perihematomal edema under mild hypothermia and an association with favorable outcome. Thus, results from ongoing, prospective randomized-controlled trials are highly anticipated.",
author = "Marlene Fischer and Alois Schiefecker and Peter Lackner and Raimund Helbok and Ronny Beer and Bettina Pfausler and Erich Schmutzhard and Gregor Broessner",
year = "2017",
language = "English",
volume = "18",
pages = "1430--1440",
journal = "CURR DRUG TARGETS",
issn = "1389-4501",
publisher = "Bentham Science Publishers B.V.",
number = "12",

}

RIS

TY - JOUR

T1 - Targeted Temperature Management in Spontaneous Intracerebral Hemorrhage: A Systematic Review

AU - Fischer, Marlene

AU - Schiefecker, Alois

AU - Lackner, Peter

AU - Helbok, Raimund

AU - Beer, Ronny

AU - Pfausler, Bettina

AU - Schmutzhard, Erich

AU - Broessner, Gregor

PY - 2017

Y1 - 2017

N2 - Fever is common in neurocritical care patients and is associated with poor outcome. Targeted temperature management (TTM), i.e. therapeutic hypothermia or controlled normothermia, after acute brain injury has been studied as a neuroprotectant for several decades. In contrast to pharmacological agents with specific targets TTM affects multiple pathophysiological mechanisms and is primarily thought to attenuate secondary brain injury. Most promising results have been obtained from experimental studies on cerebral ischemia or traumatic brain injury showing beneficial effects of hypothermia on structural and functional outcome. A positive influence of hypothermia has been observed in animal models of spontaneous intracerebral hemorrhage (ICH) improving, among others, perihematomal edema, blood-brain barrier integrity, inflammation and thrombin-induced injury. However, results regarding functional outcome are conflicting. Little data is available on the effect of TTM in humans. Single-center observational studies have shown reduced perihematomal edema under mild hypothermia and an association with favorable outcome. Thus, results from ongoing, prospective randomized-controlled trials are highly anticipated.

AB - Fever is common in neurocritical care patients and is associated with poor outcome. Targeted temperature management (TTM), i.e. therapeutic hypothermia or controlled normothermia, after acute brain injury has been studied as a neuroprotectant for several decades. In contrast to pharmacological agents with specific targets TTM affects multiple pathophysiological mechanisms and is primarily thought to attenuate secondary brain injury. Most promising results have been obtained from experimental studies on cerebral ischemia or traumatic brain injury showing beneficial effects of hypothermia on structural and functional outcome. A positive influence of hypothermia has been observed in animal models of spontaneous intracerebral hemorrhage (ICH) improving, among others, perihematomal edema, blood-brain barrier integrity, inflammation and thrombin-induced injury. However, results regarding functional outcome are conflicting. Little data is available on the effect of TTM in humans. Single-center observational studies have shown reduced perihematomal edema under mild hypothermia and an association with favorable outcome. Thus, results from ongoing, prospective randomized-controlled trials are highly anticipated.

M3 - SCORING: Review article

C2 - 27397065

VL - 18

SP - 1430

EP - 1440

JO - CURR DRUG TARGETS

JF - CURR DRUG TARGETS

SN - 1389-4501

IS - 12

ER -