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Targeted micronutrition via holo-BLG based on the farm effect in house dust mite allergic rhinoconjunctivitis patients – first evaluation in a standardized allergen exposure chamber

Standard

Targeted micronutrition via holo-BLG based on the farm effect in house dust mite allergic rhinoconjunctivitis patients – first evaluation in a standardized allergen exposure chamber. / Bergmann, Karl-Christian; Graessel, Anke; Raab, Jennifer; Banghard, Werner; Krause, Linda; Becker, Sylvia; Kugler, Sebastian; Zuberbier, Torsten; Ott, Verena B.; Kramer, Matthias F.; Roth‑Walter, Franziska; Jensen-Jarolim, Erika; Guethoff, Sonja.

In: Allergo J Int, Vol. 2021, No. 30, 2021, p. 141-149.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bergmann, K-C, Graessel, A, Raab, J, Banghard, W, Krause, L, Becker, S, Kugler, S, Zuberbier, T, Ott, VB, Kramer, MF, Roth‑Walter, F, Jensen-Jarolim, E & Guethoff, S 2021, 'Targeted micronutrition via holo-BLG based on the farm effect in house dust mite allergic rhinoconjunctivitis patients – first evaluation in a standardized allergen exposure chamber', Allergo J Int, vol. 2021, no. 30, pp. 141-149. https://doi.org/10.1007/s40629-021-00163-9

APA

Bergmann, K-C., Graessel, A., Raab, J., Banghard, W., Krause, L., Becker, S., Kugler, S., Zuberbier, T., Ott, V. B., Kramer, M. F., Roth‑Walter, F., Jensen-Jarolim, E., & Guethoff, S. (2021). Targeted micronutrition via holo-BLG based on the farm effect in house dust mite allergic rhinoconjunctivitis patients – first evaluation in a standardized allergen exposure chamber. Allergo J Int, 2021(30), 141-149. https://doi.org/10.1007/s40629-021-00163-9

Vancouver

Bergmann K-C, Graessel A, Raab J, Banghard W, Krause L, Becker S et al. Targeted micronutrition via holo-BLG based on the farm effect in house dust mite allergic rhinoconjunctivitis patients – first evaluation in a standardized allergen exposure chamber. Allergo J Int. 2021;2021(30):141-149. https://doi.org/10.1007/s40629-021-00163-9

Bibtex

@article{88ce3f68614f4dd789648f95c80c5a1b,
title = "Targeted micronutrition via holo-BLG based on the farm effect in house dust mite allergic rhinoconjunctivitis patients – first evaluation in a standardized allergen exposure chamber",
abstract = "PurposeEvaluation of a lozenge for targeted micronutrition (holo-BLG), a new invention based on the farm effect, in house dust mite (HDM) allergic rhinoconjunctivitis (ARC) patients in a standardized allergen exposure chamber (AEC).MethodsEligible HDM allergic patients were exposed to HDM raw material in an AEC for 120 min before (V1) and after (V3) 3 months of holo-BLG supplementation. Nasal, conjunctival, bronchial and other symptoms were rated by the patients every 10 min and, wellbeing, peak nasal inspiratory flow (PNIF), and lung function parameters every 30 min. Primary endpoint was the change in median Total Nasal Symptom Score (TNSS) at V3 compared to V1 at 120 min of exposure. Secondary endpoints consisted of the exploratory analysis of the temporal evolution of symptom scores using linear mixed effects models.ResultsA total of 32 patients were included in the analysis. A significant improvement of 60% (p = 0.0034) in the primary endpoint TNSS (V1 2.5 [interquartile range, IQR 1–4], V3 1.0 [IQR 1–3]) was observed. 40% improvement was seen for the Total Symptom Score (V1 5.0 [IQR 3–9], V3 3.0 [IQR 2–4]; [Wilcoxon test: confidence interval 1.5–4.0, p < 0.0003]). The analysis of the temporal evolution of all symptom scores and the personal wellbeing revealed clinically meaningful improvement over time, manifested in a lower symptom increase during the final HDM exposure. No relevant differences were observed for PNIF and lung function parameters. Safety and tolerability were rated as excellent.ConclusionsThe effect of holo-BLG resulting in immune resilience might help to fight the allergy epidemic on a new front based on targeted micronutrition of immune cells.",
author = "Karl-Christian Bergmann and Anke Graessel and Jennifer Raab and Werner Banghard and Linda Krause and Sylvia Becker and Sebastian Kugler and Torsten Zuberbier and Ott, {Verena B.} and Kramer, {Matthias F.} and Franziska Roth‑Walter and Erika Jensen-Jarolim and Sonja Guethoff",
year = "2021",
doi = "10.1007/s40629-021-00163-9",
language = "English",
volume = "2021",
pages = "141--149",
journal = "Allergo J Int",
issn = "2197-0378",
publisher = "Springer Medizin",
number = "30",

}

RIS

TY - JOUR

T1 - Targeted micronutrition via holo-BLG based on the farm effect in house dust mite allergic rhinoconjunctivitis patients – first evaluation in a standardized allergen exposure chamber

AU - Bergmann, Karl-Christian

AU - Graessel, Anke

AU - Raab, Jennifer

AU - Banghard, Werner

AU - Krause, Linda

AU - Becker, Sylvia

AU - Kugler, Sebastian

AU - Zuberbier, Torsten

AU - Ott, Verena B.

AU - Kramer, Matthias F.

AU - Roth‑Walter, Franziska

AU - Jensen-Jarolim, Erika

AU - Guethoff, Sonja

PY - 2021

Y1 - 2021

N2 - PurposeEvaluation of a lozenge for targeted micronutrition (holo-BLG), a new invention based on the farm effect, in house dust mite (HDM) allergic rhinoconjunctivitis (ARC) patients in a standardized allergen exposure chamber (AEC).MethodsEligible HDM allergic patients were exposed to HDM raw material in an AEC for 120 min before (V1) and after (V3) 3 months of holo-BLG supplementation. Nasal, conjunctival, bronchial and other symptoms were rated by the patients every 10 min and, wellbeing, peak nasal inspiratory flow (PNIF), and lung function parameters every 30 min. Primary endpoint was the change in median Total Nasal Symptom Score (TNSS) at V3 compared to V1 at 120 min of exposure. Secondary endpoints consisted of the exploratory analysis of the temporal evolution of symptom scores using linear mixed effects models.ResultsA total of 32 patients were included in the analysis. A significant improvement of 60% (p = 0.0034) in the primary endpoint TNSS (V1 2.5 [interquartile range, IQR 1–4], V3 1.0 [IQR 1–3]) was observed. 40% improvement was seen for the Total Symptom Score (V1 5.0 [IQR 3–9], V3 3.0 [IQR 2–4]; [Wilcoxon test: confidence interval 1.5–4.0, p < 0.0003]). The analysis of the temporal evolution of all symptom scores and the personal wellbeing revealed clinically meaningful improvement over time, manifested in a lower symptom increase during the final HDM exposure. No relevant differences were observed for PNIF and lung function parameters. Safety and tolerability were rated as excellent.ConclusionsThe effect of holo-BLG resulting in immune resilience might help to fight the allergy epidemic on a new front based on targeted micronutrition of immune cells.

AB - PurposeEvaluation of a lozenge for targeted micronutrition (holo-BLG), a new invention based on the farm effect, in house dust mite (HDM) allergic rhinoconjunctivitis (ARC) patients in a standardized allergen exposure chamber (AEC).MethodsEligible HDM allergic patients were exposed to HDM raw material in an AEC for 120 min before (V1) and after (V3) 3 months of holo-BLG supplementation. Nasal, conjunctival, bronchial and other symptoms were rated by the patients every 10 min and, wellbeing, peak nasal inspiratory flow (PNIF), and lung function parameters every 30 min. Primary endpoint was the change in median Total Nasal Symptom Score (TNSS) at V3 compared to V1 at 120 min of exposure. Secondary endpoints consisted of the exploratory analysis of the temporal evolution of symptom scores using linear mixed effects models.ResultsA total of 32 patients were included in the analysis. A significant improvement of 60% (p = 0.0034) in the primary endpoint TNSS (V1 2.5 [interquartile range, IQR 1–4], V3 1.0 [IQR 1–3]) was observed. 40% improvement was seen for the Total Symptom Score (V1 5.0 [IQR 3–9], V3 3.0 [IQR 2–4]; [Wilcoxon test: confidence interval 1.5–4.0, p < 0.0003]). The analysis of the temporal evolution of all symptom scores and the personal wellbeing revealed clinically meaningful improvement over time, manifested in a lower symptom increase during the final HDM exposure. No relevant differences were observed for PNIF and lung function parameters. Safety and tolerability were rated as excellent.ConclusionsThe effect of holo-BLG resulting in immune resilience might help to fight the allergy epidemic on a new front based on targeted micronutrition of immune cells.

U2 - 10.1007/s40629-021-00163-9

DO - 10.1007/s40629-021-00163-9

M3 - SCORING: Journal article

VL - 2021

SP - 141

EP - 149

JO - Allergo J Int

JF - Allergo J Int

SN - 2197-0378

IS - 30

ER -