Taking control! Structural and behavioural plasticity in response to game-based inhibition training in older adults

Simone Kühn; Robert C Lorenz; Markus Weichenberger; Maxi Becker; Marten Haesner; Julie O'Sullivan; Anika Steinert; Elisabeth Steinhagen-Thiessen; Susanne Brandhorst; Thomas Bremer; Jürgen Gallinat

doi:10.1016/j.neuroimage.2017.05.026

Taking control! Structural and behavioural plasticity in response to game-based inhibition training in older adults

Standard

Taking control! Structural and behavioural plasticity in response to game-based inhibition training in older adults. / Kühn, Simone; Lorenz, Robert C; Weichenberger, Markus; Becker, Maxi; Haesner, Marten; O'Sullivan, Julie; Steinert, Anika; Steinhagen-Thiessen, Elisabeth; Brandhorst, Susanne; Bremer, Thomas; Gallinat, Jürgen.

In: NEUROIMAGE, Vol. 156, 01.08.2017, p. 199-206.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kühn, S, Lorenz, RC, Weichenberger, M, Becker, M, Haesner, M, O'Sullivan, J, Steinert, A, Steinhagen-Thiessen, E, Brandhorst, S, Bremer, T & Gallinat, J 2017, 'Taking control! Structural and behavioural plasticity in response to game-based inhibition training in older adults', NEUROIMAGE, vol. 156, pp. 199-206. https://doi.org/10.1016/j.neuroimage.2017.05.026

APA

Kühn, S., Lorenz, R. C., Weichenberger, M., Becker, M., Haesner, M., O'Sullivan, J., Steinert, A., Steinhagen-Thiessen, E., Brandhorst, S., Bremer, T., & Gallinat, J. (2017). Taking control! Structural and behavioural plasticity in response to game-based inhibition training in older adults. NEUROIMAGE, 156, 199-206. https://doi.org/10.1016/j.neuroimage.2017.05.026

Vancouver

Kühn S, Lorenz RC, Weichenberger M, Becker M, Haesner M, O'Sullivan J et al. Taking control! Structural and behavioural plasticity in response to game-based inhibition training in older adults. NEUROIMAGE. 2017 Aug 1;156:199-206. https://doi.org/10.1016/j.neuroimage.2017.05.026

Bibtex

@article{5012a5d5364649a1a04d57b41cfeccc5,

title = "Taking control! Structural and behavioural plasticity in response to game-based inhibition training in older adults",

abstract = "While previous attempts to train self-control in humans have frequently failed, we set out to train response inhibition using computer-game elements. We trained older adults with a newly developed game-based inhibition training on a tablet for two months and compared them to an active and passive control group. Behavioural effects reflected in shorter stop signal response times that were observed only in the inhibition-training group. This was accompanied by structural growth in cortical thickness of right inferior frontal gyrus (rIFG) triangularis, a brain region that has been associated with response inhibition. The structural plasticity effect was positively associated with time spent on the training-task and predicted the final percentage of successful inhibition trials in the stop task. The data provide evidence for successful trainability of inhibition when game-based training is employed. The results extend our knowledge on game-based cognitive training effects in older age and may foster treatment research in psychiatric diseases related to impulse control.",

keywords = "Journal Article",

author = "Simone K{\"u}hn and Lorenz, {Robert C} and Markus Weichenberger and Maxi Becker and Marten Haesner and Julie O'Sullivan and Anika Steinert and Elisabeth Steinhagen-Thiessen and Susanne Brandhorst and Thomas Bremer and J{\"u}rgen Gallinat",

year = "2017",

month = aug,

day = "1",

doi = "10.1016/j.neuroimage.2017.05.026",

language = "English",

volume = "156",

pages = "199--206",

journal = "NEUROIMAGE",

issn = "1053-8119",

publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Taking control! Structural and behavioural plasticity in response to game-based inhibition training in older adults

AU - Kühn, Simone

AU - Lorenz, Robert C

AU - Weichenberger, Markus

AU - Becker, Maxi

AU - Haesner, Marten

AU - O'Sullivan, Julie

AU - Steinert, Anika

AU - Steinhagen-Thiessen, Elisabeth

AU - Brandhorst, Susanne

AU - Bremer, Thomas

AU - Gallinat, Jürgen

PY - 2017/8/1

Y1 - 2017/8/1

N2 - While previous attempts to train self-control in humans have frequently failed, we set out to train response inhibition using computer-game elements. We trained older adults with a newly developed game-based inhibition training on a tablet for two months and compared them to an active and passive control group. Behavioural effects reflected in shorter stop signal response times that were observed only in the inhibition-training group. This was accompanied by structural growth in cortical thickness of right inferior frontal gyrus (rIFG) triangularis, a brain region that has been associated with response inhibition. The structural plasticity effect was positively associated with time spent on the training-task and predicted the final percentage of successful inhibition trials in the stop task. The data provide evidence for successful trainability of inhibition when game-based training is employed. The results extend our knowledge on game-based cognitive training effects in older age and may foster treatment research in psychiatric diseases related to impulse control.

AB - While previous attempts to train self-control in humans have frequently failed, we set out to train response inhibition using computer-game elements. We trained older adults with a newly developed game-based inhibition training on a tablet for two months and compared them to an active and passive control group. Behavioural effects reflected in shorter stop signal response times that were observed only in the inhibition-training group. This was accompanied by structural growth in cortical thickness of right inferior frontal gyrus (rIFG) triangularis, a brain region that has been associated with response inhibition. The structural plasticity effect was positively associated with time spent on the training-task and predicted the final percentage of successful inhibition trials in the stop task. The data provide evidence for successful trainability of inhibition when game-based training is employed. The results extend our knowledge on game-based cognitive training effects in older age and may foster treatment research in psychiatric diseases related to impulse control.

KW - Journal Article

U2 - 10.1016/j.neuroimage.2017.05.026

DO - 10.1016/j.neuroimage.2017.05.026

M3 - SCORING: Journal article

C2 - 28527788

VL - 156

SP - 199

EP - 206

JO - NEUROIMAGE

JF - NEUROIMAGE

SN - 1053-8119

ER -