T2 and T2* measurements of fetal brain oxygenation during hypoxia with MRI at 3T: correlation with fetal arterial blood oxygen saturation.
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T2 and T2* measurements of fetal brain oxygenation during hypoxia with MRI at 3T: correlation with fetal arterial blood oxygen saturation. / Wedegärtner, Ulrike; Kooijman, Hendrik; Andreas, Thomas; Beindorff, Nicola; Hecher, Kurt; Adam, Gerhard.
In: EUR RADIOL, Vol. 20, No. 1, 1, 2010, p. 121-127.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - T2 and T2* measurements of fetal brain oxygenation during hypoxia with MRI at 3T: correlation with fetal arterial blood oxygen saturation.
AU - Wedegärtner, Ulrike
AU - Kooijman, Hendrik
AU - Andreas, Thomas
AU - Beindorff, Nicola
AU - Hecher, Kurt
AU - Adam, Gerhard
PY - 2010
Y1 - 2010
N2 - The purpose of this prospective study was to determine the oxygen saturation of blood in the fetal brain based on T2 and T2* measurements in a fetal sheep model. Five sheep fetuses were investigated during normoxia and hypoxia by 3T MRI. Multi-echo gradient-echo and turbo-spin-echo sequences were performed on the fetal brain. MR-determined oxygen saturation (MR-sO(2)) of blood in the fetal brain was calculated based on T2 and T2* values. Fetal arterial blood oxygen saturation (blood-sO(2)) was measured during the two experimental phases. The slope of MR-sO(2) as a function of blood-sO(2) was estimated and tested for compatibility using the one-sample t-test. During normoxia, mean values for carotid blood oxygen saturation were 67%, 83 ms for T2*, 202 ms for T2 and 96% for MR-sO(2). During hypoxia, arterial blood oxygen saturation, T2* and calculated MR-sO(2) decreased to 22%, 64 ms, and 68% respectively. The one-sample t-test revealed the slope to be significantly different from 0 (T = 5.023, df = 4, P = 0.007). It is feasible to perform quantitative T2 and T2* measurements in the fetal brain. MR-sO(2) and fetal arterial blood oxygen saturation correlated significantly. However, based on these data a reliable quantification of fetal brain tissue oxygenation is not possible.
AB - The purpose of this prospective study was to determine the oxygen saturation of blood in the fetal brain based on T2 and T2* measurements in a fetal sheep model. Five sheep fetuses were investigated during normoxia and hypoxia by 3T MRI. Multi-echo gradient-echo and turbo-spin-echo sequences were performed on the fetal brain. MR-determined oxygen saturation (MR-sO(2)) of blood in the fetal brain was calculated based on T2 and T2* values. Fetal arterial blood oxygen saturation (blood-sO(2)) was measured during the two experimental phases. The slope of MR-sO(2) as a function of blood-sO(2) was estimated and tested for compatibility using the one-sample t-test. During normoxia, mean values for carotid blood oxygen saturation were 67%, 83 ms for T2*, 202 ms for T2 and 96% for MR-sO(2). During hypoxia, arterial blood oxygen saturation, T2* and calculated MR-sO(2) decreased to 22%, 64 ms, and 68% respectively. The one-sample t-test revealed the slope to be significantly different from 0 (T = 5.023, df = 4, P = 0.007). It is feasible to perform quantitative T2 and T2* measurements in the fetal brain. MR-sO(2) and fetal arterial blood oxygen saturation correlated significantly. However, based on these data a reliable quantification of fetal brain tissue oxygenation is not possible.
M3 - SCORING: Zeitschriftenaufsatz
VL - 20
SP - 121
EP - 127
JO - EUR RADIOL
JF - EUR RADIOL
SN - 0938-7994
IS - 1
M1 - 1
ER -
