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T1w dark blood imaging improves detection of contrast enhancing lesions in multiple sclerosis

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T1w dark blood imaging improves detection of contrast enhancing lesions in multiple sclerosis. / Thaler, Christian; Schneider, Tanja; Sedlacik, Jan; Kutzner, Daniel; Stellmann, Jan-Patrick; Heesen, Christoph; Fiehler, Jens; Siemonsen, Susanne.

In: PLOS ONE, Vol. 12, No. 8, 2017, p. e0183099.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Thaler, C, Schneider, T, Sedlacik, J, Kutzner, D, Stellmann, J-P, Heesen, C, Fiehler, J & Siemonsen, S 2017, 'T1w dark blood imaging improves detection of contrast enhancing lesions in multiple sclerosis', PLOS ONE, vol. 12, no. 8, pp. e0183099. https://doi.org/10.1371/journal.pone.0183099

APA

Thaler, C., Schneider, T., Sedlacik, J., Kutzner, D., Stellmann, J-P., Heesen, C., Fiehler, J., & Siemonsen, S. (2017). T1w dark blood imaging improves detection of contrast enhancing lesions in multiple sclerosis. PLOS ONE, 12(8), e0183099. https://doi.org/10.1371/journal.pone.0183099

Vancouver

Thaler C, Schneider T, Sedlacik J, Kutzner D, Stellmann J-P, Heesen C et al. T1w dark blood imaging improves detection of contrast enhancing lesions in multiple sclerosis. PLOS ONE. 2017;12(8):e0183099. https://doi.org/10.1371/journal.pone.0183099

Bibtex

@article{81a01f938cc84e628c85cc2654d26345,
title = "T1w dark blood imaging improves detection of contrast enhancing lesions in multiple sclerosis",
abstract = "PURPOSE: In multiple sclerosis (MS) the sensitivity for detection of contrast enhancing lesions (CEL) in T1-weighted scans is essential for diagnostics and therapy decisions. The purpose of our study was to evaluate the sensitivity of T1w MPRAGE scans in comparison to T1w dark blood technique (T1-DB) for CEL in MS.MATERIALS AND METHODS: 3T MR imaging was performed in 37 MS patients, including T2-weighted imaging, T1w MPRAGE before and after gadolinium injection (unenhanced-T1 and T1-CE) and T1-DB imaging. After gadolinium application, the T1-DB scan was performed prior to T1-CE. From unenhanced-T1 and T1-CE scans, subtraction images (T1-SUB) were calculated. The number of CEL was determined separately on T1-CE and T1-DB by two raters independently. Lesions only detected on T1-DB scans then were verified on T1-SUB. Only lesions detected by both raters were included in further analysis.RESULTS: In 16 patients, at least one CEL was detected by both rater, either on T1-CE or T1-DB. All lesions that were detected on T1-CE were also detected on T1-DB images. The total number of contrast enhancing lesions detected on T1-DB images (n = 54) by both raters was significantly higher than the corresponding number of lesions identified on T1-CE (n = 27) (p = 0.01); all of these lesions could be verified on SUB images. In 21 patients, no CEL was detected in any of the sequences.CONCLUSIONS: The application of T1-DB technique increases the sensitivity for CEL in MS, especially for those lesions that show only subtle increase in intensity after Gadolinium application but remain hypo- or iso-intense to surrounding tissue.",
keywords = "Journal Article",
author = "Christian Thaler and Tanja Schneider and Jan Sedlacik and Daniel Kutzner and Jan-Patrick Stellmann and Christoph Heesen and Jens Fiehler and Susanne Siemonsen",
year = "2017",
doi = "10.1371/journal.pone.0183099",
language = "English",
volume = "12",
pages = "e0183099",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

RIS

TY - JOUR

T1 - T1w dark blood imaging improves detection of contrast enhancing lesions in multiple sclerosis

AU - Thaler, Christian

AU - Schneider, Tanja

AU - Sedlacik, Jan

AU - Kutzner, Daniel

AU - Stellmann, Jan-Patrick

AU - Heesen, Christoph

AU - Fiehler, Jens

AU - Siemonsen, Susanne

PY - 2017

Y1 - 2017

N2 - PURPOSE: In multiple sclerosis (MS) the sensitivity for detection of contrast enhancing lesions (CEL) in T1-weighted scans is essential for diagnostics and therapy decisions. The purpose of our study was to evaluate the sensitivity of T1w MPRAGE scans in comparison to T1w dark blood technique (T1-DB) for CEL in MS.MATERIALS AND METHODS: 3T MR imaging was performed in 37 MS patients, including T2-weighted imaging, T1w MPRAGE before and after gadolinium injection (unenhanced-T1 and T1-CE) and T1-DB imaging. After gadolinium application, the T1-DB scan was performed prior to T1-CE. From unenhanced-T1 and T1-CE scans, subtraction images (T1-SUB) were calculated. The number of CEL was determined separately on T1-CE and T1-DB by two raters independently. Lesions only detected on T1-DB scans then were verified on T1-SUB. Only lesions detected by both raters were included in further analysis.RESULTS: In 16 patients, at least one CEL was detected by both rater, either on T1-CE or T1-DB. All lesions that were detected on T1-CE were also detected on T1-DB images. The total number of contrast enhancing lesions detected on T1-DB images (n = 54) by both raters was significantly higher than the corresponding number of lesions identified on T1-CE (n = 27) (p = 0.01); all of these lesions could be verified on SUB images. In 21 patients, no CEL was detected in any of the sequences.CONCLUSIONS: The application of T1-DB technique increases the sensitivity for CEL in MS, especially for those lesions that show only subtle increase in intensity after Gadolinium application but remain hypo- or iso-intense to surrounding tissue.

AB - PURPOSE: In multiple sclerosis (MS) the sensitivity for detection of contrast enhancing lesions (CEL) in T1-weighted scans is essential for diagnostics and therapy decisions. The purpose of our study was to evaluate the sensitivity of T1w MPRAGE scans in comparison to T1w dark blood technique (T1-DB) for CEL in MS.MATERIALS AND METHODS: 3T MR imaging was performed in 37 MS patients, including T2-weighted imaging, T1w MPRAGE before and after gadolinium injection (unenhanced-T1 and T1-CE) and T1-DB imaging. After gadolinium application, the T1-DB scan was performed prior to T1-CE. From unenhanced-T1 and T1-CE scans, subtraction images (T1-SUB) were calculated. The number of CEL was determined separately on T1-CE and T1-DB by two raters independently. Lesions only detected on T1-DB scans then were verified on T1-SUB. Only lesions detected by both raters were included in further analysis.RESULTS: In 16 patients, at least one CEL was detected by both rater, either on T1-CE or T1-DB. All lesions that were detected on T1-CE were also detected on T1-DB images. The total number of contrast enhancing lesions detected on T1-DB images (n = 54) by both raters was significantly higher than the corresponding number of lesions identified on T1-CE (n = 27) (p = 0.01); all of these lesions could be verified on SUB images. In 21 patients, no CEL was detected in any of the sequences.CONCLUSIONS: The application of T1-DB technique increases the sensitivity for CEL in MS, especially for those lesions that show only subtle increase in intensity after Gadolinium application but remain hypo- or iso-intense to surrounding tissue.

KW - Journal Article

U2 - 10.1371/journal.pone.0183099

DO - 10.1371/journal.pone.0183099

M3 - SCORING: Journal article

C2 - 28797082

VL - 12

SP - e0183099

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 8

ER -