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T cell cytokines in the diagnostic of early-onset sepsis

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T cell cytokines in the diagnostic of early-onset sepsis. / Froeschle, Glenn Malin; Bedke, Tanja; Boettcher, Michael; Huber, Samuel; Singer, Dominique; Ebenebe, Chinedu Ulrich.

In: PEDIATR RES, Vol. 90, No. 1, 07.2021, p. 191-196.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Froeschle, GM, Bedke, T, Boettcher, M, Huber, S, Singer, D & Ebenebe, CU 2021, 'T cell cytokines in the diagnostic of early-onset sepsis', PEDIATR RES, vol. 90, no. 1, pp. 191-196. https://doi.org/10.1038/s41390-020-01248-x

APA

Froeschle, G. M., Bedke, T., Boettcher, M., Huber, S., Singer, D., & Ebenebe, C. U. (2021). T cell cytokines in the diagnostic of early-onset sepsis. PEDIATR RES, 90(1), 191-196. https://doi.org/10.1038/s41390-020-01248-x

Vancouver

Froeschle GM, Bedke T, Boettcher M, Huber S, Singer D, Ebenebe CU. T cell cytokines in the diagnostic of early-onset sepsis. PEDIATR RES. 2021 Jul;90(1):191-196. https://doi.org/10.1038/s41390-020-01248-x

Bibtex

@article{82053de4917f4d14b255f8d404f1e2ab,
title = "T cell cytokines in the diagnostic of early-onset sepsis",
abstract = "BACKGROUND: Early-onset sepsis (EOS) remains a substantial cause of morbidity and mortality among neonates. Yet, currently available biological parameters have not proven to be accurate enough to predict EOS reliably. This study aimed to determine serum concentrations of 13 cytokines in umbilical cord blood and evaluate their diagnostic value for EOS.METHODS: A prospective single-center study that included analysis of umbilical cord blood of term and preterm neonates who were born from March 2017 to November 2017. Using ELISA analysis, 13 cytokines were simultaneously quantified and correlated with the development of EOS.RESULTS: Four hundred and seventy-four neonates were included, of which seven met the criteria for culture-positive EOS. Interleukin (IL)-6 (p < 0.001), IL-9 (p = 0.003), and IL-21 (p < 0.001) were significantly increased in neonates with EOS compared to controls. Sensitivity and specificity for IL-6, IL-9, and IL-21 at the defined cut-off points were 85.7 and 77.3%, 71.4 and 62.5%, and 71.4 and 52.0%, respectively.CONCLUSIONS: In neonates with EOS, IL-9 and IL-21 are significantly elevated and may be employed in the diagnostic of EOS. However, diagnostic accuracy remains lower than with IL-6. Values of 13 T cell cytokines may be used as reference values for future studies in neonates.IMPACT: Interleukin-9 (IL-9) and interleukin-21 (IL-21) are significantly elevated in neonates with early-onset sepsis. IL-9 and IL-21 have been shown to play a specific role in neonatal sepsis. Neonatal reference values were generated for several cytokines. IL-9 and IL-21 might be attractive biomarkers for neonatal sepsis in future. This study is likely to promote further research in this area. Values of several T cell cytokines may be used as reference values for future studies in neonates.",
author = "Froeschle, {Glenn Malin} and Tanja Bedke and Michael Boettcher and Samuel Huber and Dominique Singer and Ebenebe, {Chinedu Ulrich}",
year = "2021",
month = jul,
doi = "10.1038/s41390-020-01248-x",
language = "English",
volume = "90",
pages = "191--196",
journal = "PEDIATR RES",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - T cell cytokines in the diagnostic of early-onset sepsis

AU - Froeschle, Glenn Malin

AU - Bedke, Tanja

AU - Boettcher, Michael

AU - Huber, Samuel

AU - Singer, Dominique

AU - Ebenebe, Chinedu Ulrich

PY - 2021/7

Y1 - 2021/7

N2 - BACKGROUND: Early-onset sepsis (EOS) remains a substantial cause of morbidity and mortality among neonates. Yet, currently available biological parameters have not proven to be accurate enough to predict EOS reliably. This study aimed to determine serum concentrations of 13 cytokines in umbilical cord blood and evaluate their diagnostic value for EOS.METHODS: A prospective single-center study that included analysis of umbilical cord blood of term and preterm neonates who were born from March 2017 to November 2017. Using ELISA analysis, 13 cytokines were simultaneously quantified and correlated with the development of EOS.RESULTS: Four hundred and seventy-four neonates were included, of which seven met the criteria for culture-positive EOS. Interleukin (IL)-6 (p < 0.001), IL-9 (p = 0.003), and IL-21 (p < 0.001) were significantly increased in neonates with EOS compared to controls. Sensitivity and specificity for IL-6, IL-9, and IL-21 at the defined cut-off points were 85.7 and 77.3%, 71.4 and 62.5%, and 71.4 and 52.0%, respectively.CONCLUSIONS: In neonates with EOS, IL-9 and IL-21 are significantly elevated and may be employed in the diagnostic of EOS. However, diagnostic accuracy remains lower than with IL-6. Values of 13 T cell cytokines may be used as reference values for future studies in neonates.IMPACT: Interleukin-9 (IL-9) and interleukin-21 (IL-21) are significantly elevated in neonates with early-onset sepsis. IL-9 and IL-21 have been shown to play a specific role in neonatal sepsis. Neonatal reference values were generated for several cytokines. IL-9 and IL-21 might be attractive biomarkers for neonatal sepsis in future. This study is likely to promote further research in this area. Values of several T cell cytokines may be used as reference values for future studies in neonates.

AB - BACKGROUND: Early-onset sepsis (EOS) remains a substantial cause of morbidity and mortality among neonates. Yet, currently available biological parameters have not proven to be accurate enough to predict EOS reliably. This study aimed to determine serum concentrations of 13 cytokines in umbilical cord blood and evaluate their diagnostic value for EOS.METHODS: A prospective single-center study that included analysis of umbilical cord blood of term and preterm neonates who were born from March 2017 to November 2017. Using ELISA analysis, 13 cytokines were simultaneously quantified and correlated with the development of EOS.RESULTS: Four hundred and seventy-four neonates were included, of which seven met the criteria for culture-positive EOS. Interleukin (IL)-6 (p < 0.001), IL-9 (p = 0.003), and IL-21 (p < 0.001) were significantly increased in neonates with EOS compared to controls. Sensitivity and specificity for IL-6, IL-9, and IL-21 at the defined cut-off points were 85.7 and 77.3%, 71.4 and 62.5%, and 71.4 and 52.0%, respectively.CONCLUSIONS: In neonates with EOS, IL-9 and IL-21 are significantly elevated and may be employed in the diagnostic of EOS. However, diagnostic accuracy remains lower than with IL-6. Values of 13 T cell cytokines may be used as reference values for future studies in neonates.IMPACT: Interleukin-9 (IL-9) and interleukin-21 (IL-21) are significantly elevated in neonates with early-onset sepsis. IL-9 and IL-21 have been shown to play a specific role in neonatal sepsis. Neonatal reference values were generated for several cytokines. IL-9 and IL-21 might be attractive biomarkers for neonatal sepsis in future. This study is likely to promote further research in this area. Values of several T cell cytokines may be used as reference values for future studies in neonates.

U2 - 10.1038/s41390-020-01248-x

DO - 10.1038/s41390-020-01248-x

M3 - SCORING: Journal article

C2 - 33173181

VL - 90

SP - 191

EP - 196

JO - PEDIATR RES

JF - PEDIATR RES

SN - 0031-3998

IS - 1

ER -