T cell Ca2+ microdomains through the lens of computational modeling

Diana C Gil Montoya; Roberto Ornelas-Guevara; Björn-Philipp Diercks; Andreas H Guse; Geneviève Dupont

doi:10.3389/fimmu.2023.1235737

T cell Ca2+ microdomains through the lens of computational modeling

Standard

T cell Ca2+ microdomains through the lens of computational modeling. / Gil Montoya, Diana C; Ornelas-Guevara, Roberto; Diercks, Björn-Philipp ; Guse, Andreas H; Dupont, Geneviève.

In: FRONT IMMUNOL, Vol. 14, 2023, p. 1235737.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Gil Montoya, DC, Ornelas-Guevara, R, Diercks, B-P , Guse, AH & Dupont, G 2023, 'T cell Ca2+ microdomains through the lens of computational modeling', FRONT IMMUNOL, vol. 14, pp. 1235737. https://doi.org/10.3389/fimmu.2023.1235737

APA

Gil Montoya, D. C., Ornelas-Guevara, R., Diercks, B-P., Guse, A. H., & Dupont, G. (2023). T cell Ca2+ microdomains through the lens of computational modeling. FRONT IMMUNOL, 14, 1235737. https://doi.org/10.3389/fimmu.2023.1235737

Vancouver

Gil Montoya DC, Ornelas-Guevara R, Diercks B-P , Guse AH, Dupont G. T cell Ca2+ microdomains through the lens of computational modeling. FRONT IMMUNOL. 2023;14:1235737. https://doi.org/10.3389/fimmu.2023.1235737

Bibtex

@article{a6651f53d11a40e6bd74e6bd04510ada,

title = "T cell Ca2+ microdomains through the lens of computational modeling",

abstract = "Cellular Ca2+ signaling is highly organized in time and space. Locally restricted and short-lived regions of Ca2+ increase, called Ca2+ microdomains, constitute building blocks that are differentially arranged to create cellular Ca2+ signatures controlling physiological responses. Here, we focus on Ca2+ microdomains occurring in restricted cytosolic spaces between the plasma membrane and the endoplasmic reticulum, called endoplasmic reticulum-plasma membrane junctions. In T cells, these microdomains have been finely characterized. Enough quantitative data are thus available to develop detailed computational models of junctional Ca2+ dynamics. Simulations are able to predict the characteristics of Ca2+ increases at the level of single channels and in junctions of different spatial configurations, in response to various signaling molecules. Thanks to the synergy between experimental observations and computational modeling, a unified description of the molecular mechanisms that create Ca2+ microdomains in the first seconds of T cell stimulation is emerging.",

keywords = "Calcium Channels/metabolism, T-Lymphocytes/metabolism, Cell Membrane/metabolism, Endoplasmic Reticulum/metabolism, Computer Simulation",

author = "{Gil Montoya}, {Diana C} and Roberto Ornelas-Guevara and Bj{\"o}rn-Philipp Diercks and Guse, {Andreas H} and Genevi{\`e}ve Dupont",

note = "Copyright {\textcopyright} 2023 Gil Montoya, Ornelas-Guevara, Diercks, Guse and Dupont.",

year = "2023",

doi = "10.3389/fimmu.2023.1235737",

language = "English",

volume = "14",

pages = "1235737",

journal = "FRONT IMMUNOL",

issn = "1664-3224",

publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - T cell Ca2+ microdomains through the lens of computational modeling

AU - Gil Montoya, Diana C

AU - Ornelas-Guevara, Roberto

AU - Diercks, Björn-Philipp

AU - Guse, Andreas H

AU - Dupont, Geneviève

PY - 2023

Y1 - 2023

N2 - Cellular Ca2+ signaling is highly organized in time and space. Locally restricted and short-lived regions of Ca2+ increase, called Ca2+ microdomains, constitute building blocks that are differentially arranged to create cellular Ca2+ signatures controlling physiological responses. Here, we focus on Ca2+ microdomains occurring in restricted cytosolic spaces between the plasma membrane and the endoplasmic reticulum, called endoplasmic reticulum-plasma membrane junctions. In T cells, these microdomains have been finely characterized. Enough quantitative data are thus available to develop detailed computational models of junctional Ca2+ dynamics. Simulations are able to predict the characteristics of Ca2+ increases at the level of single channels and in junctions of different spatial configurations, in response to various signaling molecules. Thanks to the synergy between experimental observations and computational modeling, a unified description of the molecular mechanisms that create Ca2+ microdomains in the first seconds of T cell stimulation is emerging.

AB - Cellular Ca2+ signaling is highly organized in time and space. Locally restricted and short-lived regions of Ca2+ increase, called Ca2+ microdomains, constitute building blocks that are differentially arranged to create cellular Ca2+ signatures controlling physiological responses. Here, we focus on Ca2+ microdomains occurring in restricted cytosolic spaces between the plasma membrane and the endoplasmic reticulum, called endoplasmic reticulum-plasma membrane junctions. In T cells, these microdomains have been finely characterized. Enough quantitative data are thus available to develop detailed computational models of junctional Ca2+ dynamics. Simulations are able to predict the characteristics of Ca2+ increases at the level of single channels and in junctions of different spatial configurations, in response to various signaling molecules. Thanks to the synergy between experimental observations and computational modeling, a unified description of the molecular mechanisms that create Ca2+ microdomains in the first seconds of T cell stimulation is emerging.

KW - Calcium Channels/metabolism

KW - T-Lymphocytes/metabolism

KW - Cell Membrane/metabolism

KW - Endoplasmic Reticulum/metabolism

KW - Computer Simulation

U2 - 10.3389/fimmu.2023.1235737

DO - 10.3389/fimmu.2023.1235737

M3 - SCORING: Review article

C2 - 37860008

VL - 14

SP - 1235737

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

ER -