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Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV

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Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV. / Rechtien, Anne; Richert, Laura; Lorenzo, Hadrien; Martrus, Gloria; Hejblum, Boris; Dahlke, Christine; Kasonta, Rahel; Zinser, Madeleine; Stubbe, Hans; Matschl, Urte; Lohse, Ansgar; Krähling, Verena; Eickmann, Markus; Becker, Stephan; Thiébaut, Rodolphe; Altfeld, Marcus; Addo, Marylyn M; VEBCON.

In: CELL REP, Vol. 20, No. 9, 29.08.2017, p. 2251-2261.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rechtien, A, Richert, L, Lorenzo, H, Martrus, G, Hejblum, B, Dahlke, C, Kasonta, R, Zinser, M, Stubbe, H, Matschl, U, Lohse, A, Krähling, V, Eickmann, M, Becker, S, Thiébaut, R, Altfeld, M, Addo, MM & VEBCON 2017, 'Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV', CELL REP, vol. 20, no. 9, pp. 2251-2261. https://doi.org/10.1016/j.celrep.2017.08.023

APA

Rechtien, A., Richert, L., Lorenzo, H., Martrus, G., Hejblum, B., Dahlke, C., Kasonta, R., Zinser, M., Stubbe, H., Matschl, U., Lohse, A., Krähling, V., Eickmann, M., Becker, S., Thiébaut, R., Altfeld, M., Addo, M. M., & VEBCON (2017). Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV. CELL REP, 20(9), 2251-2261. https://doi.org/10.1016/j.celrep.2017.08.023

Vancouver

Rechtien A, Richert L, Lorenzo H, Martrus G, Hejblum B, Dahlke C et al. Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV. CELL REP. 2017 Aug 29;20(9):2251-2261. https://doi.org/10.1016/j.celrep.2017.08.023

Bibtex

@article{65677cf12f4c4a9381dbe945480c736c,
title = "Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV",
abstract = "Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes in cytokine levels, innate immune cell subsets, and gene expression. Integrative statistical analyses with cross-validation identified a signature of 5 early innate markers correlating with antibody titers on day 28 and beyond. Among those, IP-10 on day 3 and MFI of CXCR6 on NK cells on day 1 were independent correlates. Consistently, we found an early gene expression signature linked to IP-10. This comprehensive characterization of early innate immune responses to the rVSV-ZEBOV vaccine in humans revealed immune signatures linked to IP-10. These results suggest correlates of vaccine-induced antibody induction and provide a rationale to explore strategies for augmenting the effectiveness of vaccines through manipulation of IP-10.",
keywords = "Journal Article",
author = "Anne Rechtien and Laura Richert and Hadrien Lorenzo and Gloria Martrus and Boris Hejblum and Christine Dahlke and Rahel Kasonta and Madeleine Zinser and Hans Stubbe and Urte Matschl and Ansgar Lohse and Verena Kr{\"a}hling and Markus Eickmann and Stephan Becker and Rodolphe Thi{\'e}baut and Marcus Altfeld and Addo, {Marylyn M} and VEBCON",
note = "Copyright {\textcopyright} 2017 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = aug,
day = "29",
doi = "10.1016/j.celrep.2017.08.023",
language = "English",
volume = "20",
pages = "2251--2261",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV

AU - Rechtien, Anne

AU - Richert, Laura

AU - Lorenzo, Hadrien

AU - Martrus, Gloria

AU - Hejblum, Boris

AU - Dahlke, Christine

AU - Kasonta, Rahel

AU - Zinser, Madeleine

AU - Stubbe, Hans

AU - Matschl, Urte

AU - Lohse, Ansgar

AU - Krähling, Verena

AU - Eickmann, Markus

AU - Becker, Stephan

AU - Thiébaut, Rodolphe

AU - Altfeld, Marcus

AU - Addo, Marylyn M

AU - VEBCON

N1 - Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2017/8/29

Y1 - 2017/8/29

N2 - Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes in cytokine levels, innate immune cell subsets, and gene expression. Integrative statistical analyses with cross-validation identified a signature of 5 early innate markers correlating with antibody titers on day 28 and beyond. Among those, IP-10 on day 3 and MFI of CXCR6 on NK cells on day 1 were independent correlates. Consistently, we found an early gene expression signature linked to IP-10. This comprehensive characterization of early innate immune responses to the rVSV-ZEBOV vaccine in humans revealed immune signatures linked to IP-10. These results suggest correlates of vaccine-induced antibody induction and provide a rationale to explore strategies for augmenting the effectiveness of vaccines through manipulation of IP-10.

AB - Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes in cytokine levels, innate immune cell subsets, and gene expression. Integrative statistical analyses with cross-validation identified a signature of 5 early innate markers correlating with antibody titers on day 28 and beyond. Among those, IP-10 on day 3 and MFI of CXCR6 on NK cells on day 1 were independent correlates. Consistently, we found an early gene expression signature linked to IP-10. This comprehensive characterization of early innate immune responses to the rVSV-ZEBOV vaccine in humans revealed immune signatures linked to IP-10. These results suggest correlates of vaccine-induced antibody induction and provide a rationale to explore strategies for augmenting the effectiveness of vaccines through manipulation of IP-10.

KW - Journal Article

U2 - 10.1016/j.celrep.2017.08.023

DO - 10.1016/j.celrep.2017.08.023

M3 - SCORING: Journal article

C2 - 28854372

VL - 20

SP - 2251

EP - 2261

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 9

ER -