Systemic treatment of liver metastases from colorectal cancer
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Systemic treatment of liver metastases from colorectal cancer. / Stein, Alexander; Schmoll, Hans-Joachim.
In: THER ADV MED ONCOL, Vol. 5, No. 3, 01.05.2013, p. 193-203.Research output: SCORING: Contribution to journal › SCORING: Journal article › Transfer › peer-review
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TY - JOUR
T1 - Systemic treatment of liver metastases from colorectal cancer
AU - Stein, Alexander
AU - Schmoll, Hans-Joachim
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Patients presenting with synchronous or metachronous colorectal cancer liver metastases (CLM) should be evaluated for multimodal management with curative intent. Preoperative systemic chemotherapy shows beneficial impact on adjuvant progression-free survival and also borderline on overall survival, without significantly increasing initially R0 resectable patients postoperative complication rates. Postoperative chemotherapy recommended based on the perioperative trial experience for those patients achieving at least stable disease during preoperative chemotherapy, or based on the adjuvant trials for patients receiving upfront resection. 'Borderline' resectable CLM, preoperative chemotherapy plays an important role in both in achievement of a resectable status and improvement of prognosis. Recent 4 drug combinations demonstrated response rates up to 80% even for advanced disease and are thus promising regimens for further evaluation in patients with resectable or unresectable liver-limited (+/- lung) disease.
AB - Patients presenting with synchronous or metachronous colorectal cancer liver metastases (CLM) should be evaluated for multimodal management with curative intent. Preoperative systemic chemotherapy shows beneficial impact on adjuvant progression-free survival and also borderline on overall survival, without significantly increasing initially R0 resectable patients postoperative complication rates. Postoperative chemotherapy recommended based on the perioperative trial experience for those patients achieving at least stable disease during preoperative chemotherapy, or based on the adjuvant trials for patients receiving upfront resection. 'Borderline' resectable CLM, preoperative chemotherapy plays an important role in both in achievement of a resectable status and improvement of prognosis. Recent 4 drug combinations demonstrated response rates up to 80% even for advanced disease and are thus promising regimens for further evaluation in patients with resectable or unresectable liver-limited (+/- lung) disease.
U2 - 10.1177/1758834012473347
DO - 10.1177/1758834012473347
M3 - SCORING: Journal article
C2 - 23634197
VL - 5
SP - 193
EP - 203
JO - THER ADV MED ONCOL
JF - THER ADV MED ONCOL
SN - 1758-8340
IS - 3
ER -