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SYNTAX score-0 patients: risk stratification in nonobstructive coronary artery disease

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SYNTAX score-0 patients: risk stratification in nonobstructive coronary artery disease. / Sinning, Christoph; Zengin, Elvin; Waldeyer, Christoph; Seiffert, Moritz; Schnabel, Renate B; Lubos, Edith; Zeller, Tanja; Bickel, Christoph; Blankenberg, Stefan; Clemmensen, Peter M; Westermann, Dirk.

In: CLIN RES CARDIOL, Vol. 105, No. 11, 11.2016, p. 901-911.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sinning, C, Zengin, E, Waldeyer, C, Seiffert, M, Schnabel, RB, Lubos, E, Zeller, T, Bickel, C, Blankenberg, S, Clemmensen, PM & Westermann, D 2016, 'SYNTAX score-0 patients: risk stratification in nonobstructive coronary artery disease', CLIN RES CARDIOL, vol. 105, no. 11, pp. 901-911. https://doi.org/10.1007/s00392-016-0998-5

APA

Sinning, C., Zengin, E., Waldeyer, C., Seiffert, M., Schnabel, R. B., Lubos, E., Zeller, T., Bickel, C., Blankenberg, S., Clemmensen, P. M., & Westermann, D. (2016). SYNTAX score-0 patients: risk stratification in nonobstructive coronary artery disease. CLIN RES CARDIOL, 105(11), 901-911. https://doi.org/10.1007/s00392-016-0998-5

Vancouver

Sinning C, Zengin E, Waldeyer C, Seiffert M, Schnabel RB, Lubos E et al. SYNTAX score-0 patients: risk stratification in nonobstructive coronary artery disease. CLIN RES CARDIOL. 2016 Nov;105(11):901-911. https://doi.org/10.1007/s00392-016-0998-5

Bibtex

@article{3e6b55dc60ff449c98bc5c4c082a67df,
title = "SYNTAX score-0 patients: risk stratification in nonobstructive coronary artery disease",
abstract = "BACKGROUND: The complexity of coronary artery disease (CAD) is a predictor of cardiovascular events in patients with >50 % diameter stenosis as determined by SYNTAX score. Here, we compare the Gensini score to SYNTAX in patients with CAD as well as apply the Gensini score in patients with nonobstructive CAD (NOB-CAD), defined by ≤50 % diameter stenosis, were the SYNTAX score cannot be utilized to define future risk.METHODS: The AtheroGene study enrolled 2316 patients [861/37.2 % with acute cardiovascular syndrome (ACS) and 1500/62.8 % with stable CAD (SCAD)]. Of these, 1966 had obstructive CAD (OB-CAD) with SYNTAX and Gensini scores available and 291 events with either cardiovascular mortality or non-fatal myocardial infarction were recorded. Furthermore, 350 patients had NOB-CAD with only Gensini score and 36 events. Median follow-up time was 4.9 years.RESULTS: In the OB-CAD cohort the SYNTAX and the Gensini score predicted outcome. Kaplan-Meier curve analysis with the dichotomized Gensini score showed a significant result (p = 0.04) in the NOB-CAD cohort. Cox Regression analysis after adjustment showed a hazard ratio (HR) of 1.33 and p = 0.04 for the Gensini score in the NOB-CAD cohort. Receiver operating characteristic curve (ROC) analysis provided the highest area under the curve (AUC) regarding the outcome for the Gensini score with 0.65 (p = 0.004). Comparing the SYNTAX and Gensini score in this cohort showed improved discrimination of patients with events by the Gensini score (p = 0.02).CONCLUSION: The Gensini score predicted events in patients with ≤50 % diameter lesions. Utilization of this score is useful to define risk in NOB-CAD patients.",
keywords = "Acute Coronary Syndrome/complications, Aged, Area Under Curve, Coronary Angiography, Coronary Stenosis/complications, Coronary Vessels/diagnostic imaging, Female, Germany, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Myocardial Infarction/etiology, Predictive Value of Tests, Prognosis, Proportional Hazards Models, ROC Curve, Reproducibility of Results, Risk Assessment, Risk Factors, Severity of Illness Index, Time Factors",
author = "Christoph Sinning and Elvin Zengin and Christoph Waldeyer and Moritz Seiffert and Schnabel, {Renate B} and Edith Lubos and Tanja Zeller and Christoph Bickel and Stefan Blankenberg and Clemmensen, {Peter M} and Dirk Westermann",
year = "2016",
month = nov,
doi = "10.1007/s00392-016-0998-5",
language = "English",
volume = "105",
pages = "901--911",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "11",

}

RIS

TY - JOUR

T1 - SYNTAX score-0 patients: risk stratification in nonobstructive coronary artery disease

AU - Sinning, Christoph

AU - Zengin, Elvin

AU - Waldeyer, Christoph

AU - Seiffert, Moritz

AU - Schnabel, Renate B

AU - Lubos, Edith

AU - Zeller, Tanja

AU - Bickel, Christoph

AU - Blankenberg, Stefan

AU - Clemmensen, Peter M

AU - Westermann, Dirk

PY - 2016/11

Y1 - 2016/11

N2 - BACKGROUND: The complexity of coronary artery disease (CAD) is a predictor of cardiovascular events in patients with >50 % diameter stenosis as determined by SYNTAX score. Here, we compare the Gensini score to SYNTAX in patients with CAD as well as apply the Gensini score in patients with nonobstructive CAD (NOB-CAD), defined by ≤50 % diameter stenosis, were the SYNTAX score cannot be utilized to define future risk.METHODS: The AtheroGene study enrolled 2316 patients [861/37.2 % with acute cardiovascular syndrome (ACS) and 1500/62.8 % with stable CAD (SCAD)]. Of these, 1966 had obstructive CAD (OB-CAD) with SYNTAX and Gensini scores available and 291 events with either cardiovascular mortality or non-fatal myocardial infarction were recorded. Furthermore, 350 patients had NOB-CAD with only Gensini score and 36 events. Median follow-up time was 4.9 years.RESULTS: In the OB-CAD cohort the SYNTAX and the Gensini score predicted outcome. Kaplan-Meier curve analysis with the dichotomized Gensini score showed a significant result (p = 0.04) in the NOB-CAD cohort. Cox Regression analysis after adjustment showed a hazard ratio (HR) of 1.33 and p = 0.04 for the Gensini score in the NOB-CAD cohort. Receiver operating characteristic curve (ROC) analysis provided the highest area under the curve (AUC) regarding the outcome for the Gensini score with 0.65 (p = 0.004). Comparing the SYNTAX and Gensini score in this cohort showed improved discrimination of patients with events by the Gensini score (p = 0.02).CONCLUSION: The Gensini score predicted events in patients with ≤50 % diameter lesions. Utilization of this score is useful to define risk in NOB-CAD patients.

AB - BACKGROUND: The complexity of coronary artery disease (CAD) is a predictor of cardiovascular events in patients with >50 % diameter stenosis as determined by SYNTAX score. Here, we compare the Gensini score to SYNTAX in patients with CAD as well as apply the Gensini score in patients with nonobstructive CAD (NOB-CAD), defined by ≤50 % diameter stenosis, were the SYNTAX score cannot be utilized to define future risk.METHODS: The AtheroGene study enrolled 2316 patients [861/37.2 % with acute cardiovascular syndrome (ACS) and 1500/62.8 % with stable CAD (SCAD)]. Of these, 1966 had obstructive CAD (OB-CAD) with SYNTAX and Gensini scores available and 291 events with either cardiovascular mortality or non-fatal myocardial infarction were recorded. Furthermore, 350 patients had NOB-CAD with only Gensini score and 36 events. Median follow-up time was 4.9 years.RESULTS: In the OB-CAD cohort the SYNTAX and the Gensini score predicted outcome. Kaplan-Meier curve analysis with the dichotomized Gensini score showed a significant result (p = 0.04) in the NOB-CAD cohort. Cox Regression analysis after adjustment showed a hazard ratio (HR) of 1.33 and p = 0.04 for the Gensini score in the NOB-CAD cohort. Receiver operating characteristic curve (ROC) analysis provided the highest area under the curve (AUC) regarding the outcome for the Gensini score with 0.65 (p = 0.004). Comparing the SYNTAX and Gensini score in this cohort showed improved discrimination of patients with events by the Gensini score (p = 0.02).CONCLUSION: The Gensini score predicted events in patients with ≤50 % diameter lesions. Utilization of this score is useful to define risk in NOB-CAD patients.

KW - Acute Coronary Syndrome/complications

KW - Aged

KW - Area Under Curve

KW - Coronary Angiography

KW - Coronary Stenosis/complications

KW - Coronary Vessels/diagnostic imaging

KW - Female

KW - Germany

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/etiology

KW - Predictive Value of Tests

KW - Prognosis

KW - Proportional Hazards Models

KW - ROC Curve

KW - Reproducibility of Results

KW - Risk Assessment

KW - Risk Factors

KW - Severity of Illness Index

KW - Time Factors

U2 - 10.1007/s00392-016-0998-5

DO - 10.1007/s00392-016-0998-5

M3 - SCORING: Journal article

C2 - 27364941

VL - 105

SP - 901

EP - 911

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 11

ER -