Research ExplorerPublicationsSynergistic Effects of DHA and Sucrose on Body Weight Gain i...

Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice

Standard

Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice. / Pauter, Anna M; Fischer, Alexander W; Bengtsson, Tore; Asadi, Abolfazl; Talamonti, Emanuela; Jacobsson, Anders.

In: NUTRIENTS, Vol. 11, No. 4, 15.04.2019.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pauter, AM, Fischer, AW, Bengtsson, T, Asadi, A, Talamonti, E & Jacobsson, A 2019, 'Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice', NUTRIENTS, vol. 11, no. 4. https://doi.org/10.3390/nu11040852

APA

Pauter, A. M., Fischer, A. W., Bengtsson, T., Asadi, A., Talamonti, E., & Jacobsson, A. (2019). Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice. NUTRIENTS, 11(4). https://doi.org/10.3390/nu11040852

Vancouver

Pauter AM, Fischer AW, Bengtsson T, Asadi A, Talamonti E, Jacobsson A. Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice. NUTRIENTS. 2019 Apr 15;11(4). https://doi.org/10.3390/nu11040852

Bibtex

@article{195c3daa23744c91857ec9bbc5723705,
title = "Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice",
abstract = "The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) is implicated in theregulation of both lipid and carbohydrate metabolism. Thus, we questioned whether dietary DHAand low or high content of sucrose impact on metabolism in mice deficient for elongation of verylong-chain fatty acids 2 (ELOVL2), an enzyme involved in the endogenous DHA synthesis. Wefound that Elovl2 -/- mice fed a high-sucrose DHA-enriched diet followed by the high sucrose, highfat challenge significantly increased body weight. This diet affected the triglyceride rich lipoproteinfraction of plasma lipoproteins and changed the expression of several genes involved in lipidmetabolism in a white adipose tissue. Our findings suggest that lipogenesis in mammals issynergistically influenced by DHA dietary and sucrose content.",
keywords = "Acetyltransferases/genetics, Adipose Tissue, White/drug effects, Animals, Diet, High-Fat, Dietary Fats/administration & dosage, Dietary Sucrose/pharmacology, Docosahexaenoic Acids/deficiency, Fatty Acid Elongases, Lipogenesis/drug effects, Lipoproteins/blood, Mice, Knockout, Triglycerides/blood, Weight Gain/drug effects",
author = "Pauter, {Anna M} and Fischer, {Alexander W} and Tore Bengtsson and Abolfazl Asadi and Emanuela Talamonti and Anders Jacobsson",
year = "2019",
month = apr,
day = "15",
doi = "10.3390/nu11040852",
language = "English",
volume = "11",
journal = "NUTRIENTS",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

RIS

TY - JOUR

T1 - Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice

AU - Pauter, Anna M

AU - Fischer, Alexander W

AU - Bengtsson, Tore

AU - Asadi, Abolfazl

AU - Talamonti, Emanuela

AU - Jacobsson, Anders

PY - 2019/4/15

Y1 - 2019/4/15

N2 - The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) is implicated in theregulation of both lipid and carbohydrate metabolism. Thus, we questioned whether dietary DHAand low or high content of sucrose impact on metabolism in mice deficient for elongation of verylong-chain fatty acids 2 (ELOVL2), an enzyme involved in the endogenous DHA synthesis. Wefound that Elovl2 -/- mice fed a high-sucrose DHA-enriched diet followed by the high sucrose, highfat challenge significantly increased body weight. This diet affected the triglyceride rich lipoproteinfraction of plasma lipoproteins and changed the expression of several genes involved in lipidmetabolism in a white adipose tissue. Our findings suggest that lipogenesis in mammals issynergistically influenced by DHA dietary and sucrose content.

AB - The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) is implicated in theregulation of both lipid and carbohydrate metabolism. Thus, we questioned whether dietary DHAand low or high content of sucrose impact on metabolism in mice deficient for elongation of verylong-chain fatty acids 2 (ELOVL2), an enzyme involved in the endogenous DHA synthesis. Wefound that Elovl2 -/- mice fed a high-sucrose DHA-enriched diet followed by the high sucrose, highfat challenge significantly increased body weight. This diet affected the triglyceride rich lipoproteinfraction of plasma lipoproteins and changed the expression of several genes involved in lipidmetabolism in a white adipose tissue. Our findings suggest that lipogenesis in mammals issynergistically influenced by DHA dietary and sucrose content.

KW - Acetyltransferases/genetics

KW - Adipose Tissue, White/drug effects

KW - Animals

KW - Diet, High-Fat

KW - Dietary Fats/administration & dosage

KW - Dietary Sucrose/pharmacology

KW - Docosahexaenoic Acids/deficiency

KW - Fatty Acid Elongases

KW - Lipogenesis/drug effects

KW - Lipoproteins/blood

KW - Mice, Knockout

KW - Triglycerides/blood

KW - Weight Gain/drug effects

U2 - 10.3390/nu11040852

DO - 10.3390/nu11040852

M3 - SCORING: Journal article

C2 - 30991731

VL - 11

JO - NUTRIENTS

JF - NUTRIENTS

SN - 2072-6643

IS - 4

ER -