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Synergistic cytotoxic activity of treosulfan and gemcitabine in pancreatic cancer cell lines

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Synergistic cytotoxic activity of treosulfan and gemcitabine in pancreatic cancer cell lines. / Nitsch, Emilia ; Mina, Sormeh; Brammer, Ingo ; Pace, Andrea; Schuch, Gunter; Bokemeyer, Carsten; Zander, Axel; Kröger, Nicolaus-Martin; Ayuketang, Francis Ayuk.

In: ANTICANCER RES, Vol. 34, No. 4, 01.04.2014, p. 1779-84.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nitsch, E, Mina, S, Brammer, I, Pace, A, Schuch, G, Bokemeyer, C, Zander, A, Kröger, N-M & Ayuketang, FA 2014, 'Synergistic cytotoxic activity of treosulfan and gemcitabine in pancreatic cancer cell lines', ANTICANCER RES, vol. 34, no. 4, pp. 1779-84.

APA

Nitsch, E., Mina, S., Brammer, I., Pace, A., Schuch, G., Bokemeyer, C., Zander, A., Kröger, N-M., & Ayuketang, F. A. (2014). Synergistic cytotoxic activity of treosulfan and gemcitabine in pancreatic cancer cell lines. ANTICANCER RES, 34(4), 1779-84.

Vancouver

Nitsch E, Mina S, Brammer I, Pace A, Schuch G, Bokemeyer C et al. Synergistic cytotoxic activity of treosulfan and gemcitabine in pancreatic cancer cell lines. ANTICANCER RES. 2014 Apr 1;34(4):1779-84.

Bibtex

@article{2dbdbe0d3f8647d6865bf656f497eac1,
title = "Synergistic cytotoxic activity of treosulfan and gemcitabine in pancreatic cancer cell lines",
abstract = "BACKGROUND: Treatment for advanced pancreatic cancer is still very unsatisfactory. Treosulfan is an alkylating agent used for conventional, as well as high-dose chemotherapy regimens, whereby plasma concentrations over 500 μg/ml can be achieved. We investigated the effects of treosulfan on pancreatic cancer cell lines.MATERIALS AND METHODS: Using Panc-1, MIA PaCa-2 and Capan-2 cell lines, we investigated the in vitro cytotoxicity of treosulfan-alone and in combination with gemcitabine, 5-fluorouracil or irradiation.RESULTS: Treosulfan was potently cytotoxic against all pancreatic cancer cell lines at all concentrations (1-100 μg/ml). Combination of treosulfan and gemcitabine revealed strong synergistic effects independent of the sequence of drug administration. Similarly, synergism was observed with irradiation. Combination of treosulfan and 5-fluorouracil revealed antagonism.CONCLUSION: Treosulfan effectively kills pancreatic carcinoma cells in vitro and has synergistic activity in combination with gemcitabine and irradiation. These results warrant further investigation of treosulfan in the treatment of pancreatic cancer.",
keywords = "Antineoplastic Agents, Busulfan, Cell Line, Tumor, Cell Proliferation, Deoxycytidine, Dose-Response Relationship, Drug, Drug Antagonism, Drug Synergism, Fluorouracil, Humans, Pancreatic Neoplasms",
author = "Emilia Nitsch and Sormeh Mina and Ingo Brammer and Andrea Pace and Gunter Schuch and Carsten Bokemeyer and Axel Zander and Nicolaus-Martin Kr{\"o}ger and Ayuketang, {Francis Ayuk}",
year = "2014",
month = apr,
day = "1",
language = "English",
volume = "34",
pages = "1779--84",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "4",

}

RIS

TY - JOUR

T1 - Synergistic cytotoxic activity of treosulfan and gemcitabine in pancreatic cancer cell lines

AU - Nitsch, Emilia

AU - Mina, Sormeh

AU - Brammer, Ingo

AU - Pace, Andrea

AU - Schuch, Gunter

AU - Bokemeyer, Carsten

AU - Zander, Axel

AU - Kröger, Nicolaus-Martin

AU - Ayuketang, Francis Ayuk

PY - 2014/4/1

Y1 - 2014/4/1

N2 - BACKGROUND: Treatment for advanced pancreatic cancer is still very unsatisfactory. Treosulfan is an alkylating agent used for conventional, as well as high-dose chemotherapy regimens, whereby plasma concentrations over 500 μg/ml can be achieved. We investigated the effects of treosulfan on pancreatic cancer cell lines.MATERIALS AND METHODS: Using Panc-1, MIA PaCa-2 and Capan-2 cell lines, we investigated the in vitro cytotoxicity of treosulfan-alone and in combination with gemcitabine, 5-fluorouracil or irradiation.RESULTS: Treosulfan was potently cytotoxic against all pancreatic cancer cell lines at all concentrations (1-100 μg/ml). Combination of treosulfan and gemcitabine revealed strong synergistic effects independent of the sequence of drug administration. Similarly, synergism was observed with irradiation. Combination of treosulfan and 5-fluorouracil revealed antagonism.CONCLUSION: Treosulfan effectively kills pancreatic carcinoma cells in vitro and has synergistic activity in combination with gemcitabine and irradiation. These results warrant further investigation of treosulfan in the treatment of pancreatic cancer.

AB - BACKGROUND: Treatment for advanced pancreatic cancer is still very unsatisfactory. Treosulfan is an alkylating agent used for conventional, as well as high-dose chemotherapy regimens, whereby plasma concentrations over 500 μg/ml can be achieved. We investigated the effects of treosulfan on pancreatic cancer cell lines.MATERIALS AND METHODS: Using Panc-1, MIA PaCa-2 and Capan-2 cell lines, we investigated the in vitro cytotoxicity of treosulfan-alone and in combination with gemcitabine, 5-fluorouracil or irradiation.RESULTS: Treosulfan was potently cytotoxic against all pancreatic cancer cell lines at all concentrations (1-100 μg/ml). Combination of treosulfan and gemcitabine revealed strong synergistic effects independent of the sequence of drug administration. Similarly, synergism was observed with irradiation. Combination of treosulfan and 5-fluorouracil revealed antagonism.CONCLUSION: Treosulfan effectively kills pancreatic carcinoma cells in vitro and has synergistic activity in combination with gemcitabine and irradiation. These results warrant further investigation of treosulfan in the treatment of pancreatic cancer.

KW - Antineoplastic Agents

KW - Busulfan

KW - Cell Line, Tumor

KW - Cell Proliferation

KW - Deoxycytidine

KW - Dose-Response Relationship, Drug

KW - Drug Antagonism

KW - Drug Synergism

KW - Fluorouracil

KW - Humans

KW - Pancreatic Neoplasms

M3 - SCORING: Journal article

C2 - 24692710

VL - 34

SP - 1779

EP - 1784

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 4

ER -