Syndecan-1 as a biomarker for sepsis survival after major abdominal surgery
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Abstract
AIM: Sepsis is a serious complication following surgery and identification of patients at risk is of high importance. Syndecan-1 (sSDC1) levels are known to be elevated during sepsis.
MATERIALS & METHODS: Fifty-five patients scheduled for major abdominal surgery were prospectively included and sSDC1 concentrations were measured during hospital stay.
RESULTS: Patients with postoperative sepsis showed a continued increase of sSDC1 levels and exhibited higher median sSDC1 concentrations at day 1 compared with nonseptic patients 90.3 versus 16.5 ng/ml. A significant association of sSDC1 levels with the incidence of sepsis and death was demonstrated.
CONCLUSION: This study identifies sSDC1 as potential biomarker for sepsis and survival after abdominal surgery.
Bibliographical data
Original language | English |
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ISSN | 1752-0363 |
DOIs | |
Publication status | Published - 02.2018 |
PubMed | 29327601 |
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