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Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin

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Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin. / Salar, Seda; Lapilover, Ezequiel; Müller, Julia; Hollnagel, Jan-Oliver; Lippmann, Kristina; Friedman, Alon; Heinemann, Uwe.

In: NEUROBIOL DIS, Vol. 91, 07.2016, p. 155-65.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Salar, S, Lapilover, E, Müller, J, Hollnagel, J-O, Lippmann, K, Friedman, A & Heinemann, U 2016, 'Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin', NEUROBIOL DIS, vol. 91, pp. 155-65. https://doi.org/10.1016/j.nbd.2016.03.008

APA

Salar, S., Lapilover, E., Müller, J., Hollnagel, J-O., Lippmann, K., Friedman, A., & Heinemann, U. (2016). Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin. NEUROBIOL DIS, 91, 155-65. https://doi.org/10.1016/j.nbd.2016.03.008

Vancouver

Salar S, Lapilover E, Müller J, Hollnagel J-O, Lippmann K, Friedman A et al. Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin. NEUROBIOL DIS. 2016 Jul;91:155-65. https://doi.org/10.1016/j.nbd.2016.03.008

Bibtex

@article{33fdbca5f8264d74a946a11132a96123,
title = "Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin",
abstract = "Epileptogenesis following insults to the brain may be triggered by a dysfunctional blood-brain barrier (BBB) associated with albumin extravasation and activation of astrocytes. Using ex vivo recordings from the BBB-disrupted hippocampus after neocortical photothrombotic stroke, we previously demonstrated abnormal activity-dependent accumulation of extracellular potassium with facilitated generation of seizure like events and spreading depolarizations. Similar changes could be observed after intracerebroventricular (icv) application of albumin. We hypothesized that alterations in extracellular potassium and glutamate homeostasis might lead to alterations in synaptic interactions. We therefore assessed the effects of icv albumin on homo- and heterosynaptic plasticity in hippocampal CA1, 24h after a single injection or 7days after continuous infusion of icv albumin. We demonstrate alterations in both homo- and heterosynaptic plasticity compared to control conditions in ex vivo slice studies. Albumin-treated tissue reveals (1) reduced long-term depression following low-frequency stimulation; (2) increased long-term potentiation of population spikes in response to 20Hz stimulation; (3) potentiated responses to Schaffer collateral stimulation following high-frequency stimulation of the direct cortical input and low-frequency stimulation of alveus and finally, (4) TGFβ receptor II (TGFβR-II) involvement in albumin-induced homosynaptic plasticity changes. We conclude that albumin-induced network hyperexcitability is associated with abnormal homo- and heterosynaptic plasticity that could partly be reversed by interference with TGFβR-II-mediated signaling and therefore it might be an important factor in the process of epileptogenesis.",
keywords = "Journal Article",
author = "Seda Salar and Ezequiel Lapilover and Julia M{\"u}ller and Jan-Oliver Hollnagel and Kristina Lippmann and Alon Friedman and Uwe Heinemann",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = jul,
doi = "10.1016/j.nbd.2016.03.008",
language = "English",
volume = "91",
pages = "155--65",
journal = "NEUROBIOL DIS",
issn = "0969-9961",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin

AU - Salar, Seda

AU - Lapilover, Ezequiel

AU - Müller, Julia

AU - Hollnagel, Jan-Oliver

AU - Lippmann, Kristina

AU - Friedman, Alon

AU - Heinemann, Uwe

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/7

Y1 - 2016/7

N2 - Epileptogenesis following insults to the brain may be triggered by a dysfunctional blood-brain barrier (BBB) associated with albumin extravasation and activation of astrocytes. Using ex vivo recordings from the BBB-disrupted hippocampus after neocortical photothrombotic stroke, we previously demonstrated abnormal activity-dependent accumulation of extracellular potassium with facilitated generation of seizure like events and spreading depolarizations. Similar changes could be observed after intracerebroventricular (icv) application of albumin. We hypothesized that alterations in extracellular potassium and glutamate homeostasis might lead to alterations in synaptic interactions. We therefore assessed the effects of icv albumin on homo- and heterosynaptic plasticity in hippocampal CA1, 24h after a single injection or 7days after continuous infusion of icv albumin. We demonstrate alterations in both homo- and heterosynaptic plasticity compared to control conditions in ex vivo slice studies. Albumin-treated tissue reveals (1) reduced long-term depression following low-frequency stimulation; (2) increased long-term potentiation of population spikes in response to 20Hz stimulation; (3) potentiated responses to Schaffer collateral stimulation following high-frequency stimulation of the direct cortical input and low-frequency stimulation of alveus and finally, (4) TGFβ receptor II (TGFβR-II) involvement in albumin-induced homosynaptic plasticity changes. We conclude that albumin-induced network hyperexcitability is associated with abnormal homo- and heterosynaptic plasticity that could partly be reversed by interference with TGFβR-II-mediated signaling and therefore it might be an important factor in the process of epileptogenesis.

AB - Epileptogenesis following insults to the brain may be triggered by a dysfunctional blood-brain barrier (BBB) associated with albumin extravasation and activation of astrocytes. Using ex vivo recordings from the BBB-disrupted hippocampus after neocortical photothrombotic stroke, we previously demonstrated abnormal activity-dependent accumulation of extracellular potassium with facilitated generation of seizure like events and spreading depolarizations. Similar changes could be observed after intracerebroventricular (icv) application of albumin. We hypothesized that alterations in extracellular potassium and glutamate homeostasis might lead to alterations in synaptic interactions. We therefore assessed the effects of icv albumin on homo- and heterosynaptic plasticity in hippocampal CA1, 24h after a single injection or 7days after continuous infusion of icv albumin. We demonstrate alterations in both homo- and heterosynaptic plasticity compared to control conditions in ex vivo slice studies. Albumin-treated tissue reveals (1) reduced long-term depression following low-frequency stimulation; (2) increased long-term potentiation of population spikes in response to 20Hz stimulation; (3) potentiated responses to Schaffer collateral stimulation following high-frequency stimulation of the direct cortical input and low-frequency stimulation of alveus and finally, (4) TGFβ receptor II (TGFβR-II) involvement in albumin-induced homosynaptic plasticity changes. We conclude that albumin-induced network hyperexcitability is associated with abnormal homo- and heterosynaptic plasticity that could partly be reversed by interference with TGFβR-II-mediated signaling and therefore it might be an important factor in the process of epileptogenesis.

KW - Journal Article

U2 - 10.1016/j.nbd.2016.03.008

DO - 10.1016/j.nbd.2016.03.008

M3 - SCORING: Journal article

C2 - 26972679

VL - 91

SP - 155

EP - 165

JO - NEUROBIOL DIS

JF - NEUROBIOL DIS

SN - 0969-9961

ER -