Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke.
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Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke. / Schulze, Friedrich; Carter, Angela M; Schwedhelm, Edzard; Ajjan, Ramzi; Maas, Renke; von Holten, Rouven-Alexander; Atzler, Dorothee; Grant, Peter J; Böger, Rainer.
In: ATHEROSCLEROSIS, Vol. 208, No. 2, 2, 2010, p. 518-523.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke.
AU - Schulze, Friedrich
AU - Carter, Angela M
AU - Schwedhelm, Edzard
AU - Ajjan, Ramzi
AU - Maas, Renke
AU - von Holten, Rouven-Alexander
AU - Atzler, Dorothee
AU - Grant, Peter J
AU - Böger, Rainer
PY - 2010
Y1 - 2010
N2 - OBJECTIVE: Methylarginines have been shown to interfere with nitric oxide (NO) formation by inhibiting NO synthase (asymmetric dimethylarginine, ADMA, and monomethylarginine, NMMA) and the cellular l-arginine uptake system (ADMA, NMMA and symmetric dimethylarginine, SDMA), thereby causing endothelial dysfunction. ADMA is a predictor of cardiovascular events and mortality in diverse populations. METHODS: We investigated whether methylarginines are predictors of mortality in 394 patients after acute ischemic stroke during 7.4 years of follow-up. RESULTS: Patients who died (N=231) were older and more frequently had one of the traditional risk factors for stroke (previous stroke/TIA, atrial fibrillation, prevalent ischemic heart disease, peripheral vascular disease, each p
AB - OBJECTIVE: Methylarginines have been shown to interfere with nitric oxide (NO) formation by inhibiting NO synthase (asymmetric dimethylarginine, ADMA, and monomethylarginine, NMMA) and the cellular l-arginine uptake system (ADMA, NMMA and symmetric dimethylarginine, SDMA), thereby causing endothelial dysfunction. ADMA is a predictor of cardiovascular events and mortality in diverse populations. METHODS: We investigated whether methylarginines are predictors of mortality in 394 patients after acute ischemic stroke during 7.4 years of follow-up. RESULTS: Patients who died (N=231) were older and more frequently had one of the traditional risk factors for stroke (previous stroke/TIA, atrial fibrillation, prevalent ischemic heart disease, peripheral vascular disease, each p
M3 - SCORING: Zeitschriftenaufsatz
VL - 208
SP - 518
EP - 523
JO - ATHEROSCLEROSIS
JF - ATHEROSCLEROSIS
SN - 0021-9150
IS - 2
M1 - 2
ER -