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Survival and overall treatment time after postoperative radio(chemo)therapy in patients with head and neck cancer

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Survival and overall treatment time after postoperative radio(chemo)therapy in patients with head and neck cancer. / Tribius, Silke; Donner, Johanna; Pazdyka, Henning; Münscher, Adrian; Gröbe, Alexander; Petersen, Cordula; Krüll, Andreas; Tennstedt, Pierre.

In: HEAD NECK-J SCI SPEC, Vol. 38, No. 7, 13.02.2016, p. 1058-1065.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tribius, S, Donner, J, Pazdyka, H, Münscher, A, Gröbe, A, Petersen, C, Krüll, A & Tennstedt, P 2016, 'Survival and overall treatment time after postoperative radio(chemo)therapy in patients with head and neck cancer', HEAD NECK-J SCI SPEC, vol. 38, no. 7, pp. 1058-1065. https://doi.org/10.1002/hed.24407

APA

Tribius, S., Donner, J., Pazdyka, H., Münscher, A., Gröbe, A., Petersen, C., Krüll, A., & Tennstedt, P. (2016). Survival and overall treatment time after postoperative radio(chemo)therapy in patients with head and neck cancer. HEAD NECK-J SCI SPEC, 38(7), 1058-1065. https://doi.org/10.1002/hed.24407

Vancouver

Tribius S, Donner J, Pazdyka H, Münscher A, Gröbe A, Petersen C et al. Survival and overall treatment time after postoperative radio(chemo)therapy in patients with head and neck cancer. HEAD NECK-J SCI SPEC. 2016 Feb 13;38(7):1058-1065. https://doi.org/10.1002/hed.24407

Bibtex

@article{e0518e26106f4ba9b7ac67da3ee71627,
title = "Survival and overall treatment time after postoperative radio(chemo)therapy in patients with head and neck cancer",
abstract = "BACKGROUND: Generally, overall treatment time for patients with locally advanced head and neck cancer should be as short as reasonably possible. This analysis was undertaken to determine at what overall treatment time additional survival/locoregional control benefits could be achieved compared to a 100-day cutoff.METHODS: Clinical impact of overall treatment time was assessed in 272 patients by multivariable Cox regression and Kaplan-Meier analyses using the historical 100-day cutoff and the optimal overall treatment time, determined using recursive partitioning analysis. Survival endpoints were determined for the 100-day and optimal overall treatment times validated using bootstrap resampling.RESULTS: Recursive partitioning determined the optimal overall treatment time as 87 days. In the 87-day multivariable analysis, adverse factors for overall survival (OS) and disease-free survival (DFS) were overall treatment time ≥87 days and extracapsular spread, and overall treatment time and R1 status, respectively.CONCLUSION: Overall treatment time is important for survival in patients with head and neck cancer. Completing treatment within as short a timeframe as possible may be associated with longer OS and DFS. {\textcopyright} 2016 Wiley Periodicals, Inc. Head Neck, 2016.",
author = "Silke Tribius and Johanna Donner and Henning Pazdyka and Adrian M{\"u}nscher and Alexander Gr{\"o}be and Cordula Petersen and Andreas Kr{\"u}ll and Pierre Tennstedt",
note = "{\textcopyright} 2016 Wiley Periodicals, Inc.",
year = "2016",
month = feb,
day = "13",
doi = "10.1002/hed.24407",
language = "English",
volume = "38",
pages = "1058--1065",
journal = "HEAD NECK-J SCI SPEC",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - Survival and overall treatment time after postoperative radio(chemo)therapy in patients with head and neck cancer

AU - Tribius, Silke

AU - Donner, Johanna

AU - Pazdyka, Henning

AU - Münscher, Adrian

AU - Gröbe, Alexander

AU - Petersen, Cordula

AU - Krüll, Andreas

AU - Tennstedt, Pierre

N1 - © 2016 Wiley Periodicals, Inc.

PY - 2016/2/13

Y1 - 2016/2/13

N2 - BACKGROUND: Generally, overall treatment time for patients with locally advanced head and neck cancer should be as short as reasonably possible. This analysis was undertaken to determine at what overall treatment time additional survival/locoregional control benefits could be achieved compared to a 100-day cutoff.METHODS: Clinical impact of overall treatment time was assessed in 272 patients by multivariable Cox regression and Kaplan-Meier analyses using the historical 100-day cutoff and the optimal overall treatment time, determined using recursive partitioning analysis. Survival endpoints were determined for the 100-day and optimal overall treatment times validated using bootstrap resampling.RESULTS: Recursive partitioning determined the optimal overall treatment time as 87 days. In the 87-day multivariable analysis, adverse factors for overall survival (OS) and disease-free survival (DFS) were overall treatment time ≥87 days and extracapsular spread, and overall treatment time and R1 status, respectively.CONCLUSION: Overall treatment time is important for survival in patients with head and neck cancer. Completing treatment within as short a timeframe as possible may be associated with longer OS and DFS. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.

AB - BACKGROUND: Generally, overall treatment time for patients with locally advanced head and neck cancer should be as short as reasonably possible. This analysis was undertaken to determine at what overall treatment time additional survival/locoregional control benefits could be achieved compared to a 100-day cutoff.METHODS: Clinical impact of overall treatment time was assessed in 272 patients by multivariable Cox regression and Kaplan-Meier analyses using the historical 100-day cutoff and the optimal overall treatment time, determined using recursive partitioning analysis. Survival endpoints were determined for the 100-day and optimal overall treatment times validated using bootstrap resampling.RESULTS: Recursive partitioning determined the optimal overall treatment time as 87 days. In the 87-day multivariable analysis, adverse factors for overall survival (OS) and disease-free survival (DFS) were overall treatment time ≥87 days and extracapsular spread, and overall treatment time and R1 status, respectively.CONCLUSION: Overall treatment time is important for survival in patients with head and neck cancer. Completing treatment within as short a timeframe as possible may be associated with longer OS and DFS. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.

U2 - 10.1002/hed.24407

DO - 10.1002/hed.24407

M3 - SCORING: Journal article

C2 - 26873810

VL - 38

SP - 1058

EP - 1065

JO - HEAD NECK-J SCI SPEC

JF - HEAD NECK-J SCI SPEC

SN - 1043-3074

IS - 7

ER -