Survival after nephroureterectomy for upper tract urothelial carcinoma: a population-based competing-risks analysis
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Survival after nephroureterectomy for upper tract urothelial carcinoma: a population-based competing-risks analysis. / Gandaglia, Giorgio; Bianchi, Marco; Trinh, Quoc-Dien; Becker, Andreas; Larouche, Alexandre; Abdollah, Firas; Roghmann, Florian; Tian, Zhe; Shariat, Shahrokh F; Briganti, Alberto; Montorsi, Francesco; Karakiewicz, Pierre I; Sun, Maxine.
In: INT J UROL, Vol. 21, No. 3, 01.03.2014, p. 249-256.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Survival after nephroureterectomy for upper tract urothelial carcinoma: a population-based competing-risks analysis
AU - Gandaglia, Giorgio
AU - Bianchi, Marco
AU - Trinh, Quoc-Dien
AU - Becker, Andreas
AU - Larouche, Alexandre
AU - Abdollah, Firas
AU - Roghmann, Florian
AU - Tian, Zhe
AU - Shariat, Shahrokh F
AU - Briganti, Alberto
AU - Montorsi, Francesco
AU - Karakiewicz, Pierre I
AU - Sun, Maxine
N1 - © 2013 The Japanese Urological Association.
PY - 2014/3/1
Y1 - 2014/3/1
N2 - OBJECTIVES: To examine the rates of cancer-specific mortality, other-cause and bladder cancer mortality in patients with upper-tract urothelial carcinoma undergoing radical nephroureterectomy.METHODS: Relying on the Surveillance, Epidemiology, and End Results database, 9899 patients treated with radical nephroureterectomy were identified. A 20-strata graphical aid was constructed using age (<60, 60-69, 70-79, >79 years) and American Joint Committee on Cancer/TNM stage (pT₁N₀/x , pT₂N₀/x , pT₃N₀/x , pT₄N₀/x , pTany pN₁₋₃) as stratifying variables. The 5-year cancer-specific mortality, other-cause and bladder cancer mortality rates were generated through competing-risks Poisson regression methodologies. Multivariable competing-risks regression models were used to test the effect of age and stage on three different end-points: cancer-specific mortality, other-cause and bladder cancer mortality.RESULTS: Overall, 1797 (18.1%), 891 (9.1%) and 3090 (31.2%) patients died of cancer-specific mortality, other-cause and bladder cancer mortality, respectively. Following stratification according to age and stage, the proportion of patients who succumbed to cancer-specific mortality (11.7-21.9%) and other-cause mortality (8.9-30.4%) increased with age. In contrast, with increasing stage, the proportion of patients who died of cancer-specific mortality increased (7.2-37.5%), whereas the proportion of other-cause mortality remained stable (18.9-22.0%). The rate of bladder cancer mortality increased with advancing stage. At multivariable competing-risk regression model, besides age and stage, women, type of surgery, grade and location were associated with higher cancer-specific mortality. Furthermore, ureteral location, stage and grade were associated with bladder cancer mortality.CONCLUSIONS: The developed graphical aid for prediction of cancer-specific mortality, other-cause, and bladder cancer mortality according to age and stage in patients with upper-tract urothelial carcinoma undergoing radical nephroureterectomy can be useful for physicians and patients during clinical counseling.
AB - OBJECTIVES: To examine the rates of cancer-specific mortality, other-cause and bladder cancer mortality in patients with upper-tract urothelial carcinoma undergoing radical nephroureterectomy.METHODS: Relying on the Surveillance, Epidemiology, and End Results database, 9899 patients treated with radical nephroureterectomy were identified. A 20-strata graphical aid was constructed using age (<60, 60-69, 70-79, >79 years) and American Joint Committee on Cancer/TNM stage (pT₁N₀/x , pT₂N₀/x , pT₃N₀/x , pT₄N₀/x , pTany pN₁₋₃) as stratifying variables. The 5-year cancer-specific mortality, other-cause and bladder cancer mortality rates were generated through competing-risks Poisson regression methodologies. Multivariable competing-risks regression models were used to test the effect of age and stage on three different end-points: cancer-specific mortality, other-cause and bladder cancer mortality.RESULTS: Overall, 1797 (18.1%), 891 (9.1%) and 3090 (31.2%) patients died of cancer-specific mortality, other-cause and bladder cancer mortality, respectively. Following stratification according to age and stage, the proportion of patients who succumbed to cancer-specific mortality (11.7-21.9%) and other-cause mortality (8.9-30.4%) increased with age. In contrast, with increasing stage, the proportion of patients who died of cancer-specific mortality increased (7.2-37.5%), whereas the proportion of other-cause mortality remained stable (18.9-22.0%). The rate of bladder cancer mortality increased with advancing stage. At multivariable competing-risk regression model, besides age and stage, women, type of surgery, grade and location were associated with higher cancer-specific mortality. Furthermore, ureteral location, stage and grade were associated with bladder cancer mortality.CONCLUSIONS: The developed graphical aid for prediction of cancer-specific mortality, other-cause, and bladder cancer mortality according to age and stage in patients with upper-tract urothelial carcinoma undergoing radical nephroureterectomy can be useful for physicians and patients during clinical counseling.
U2 - 10.1111/iju.12267
DO - 10.1111/iju.12267
M3 - SCORING: Journal article
C2 - 24033809
VL - 21
SP - 249
EP - 256
JO - INT J UROL
JF - INT J UROL
SN - 0919-8172
IS - 3
ER -
