Surrogate based continuous noninvasive blood pressure measurement

TY - JOUR

T1 - Surrogate based continuous noninvasive blood pressure measurement

AU - Pielmus, Alexandru-Gabriel

AU - Mühlstef, Jens

AU - Bresch, Erik

AU - Glos, Martin

AU - Jungen, Christiane

AU - Mieke, Stefan

AU - Orglmeister, Reinhold

AU - Schulze, Andreas

AU - Stender, Birgit

AU - Voigt, Verena

AU - Zaunseder, Sebastian

N1 - © 2021 Walter de Gruyter GmbH, Berlin/Boston.

PY - 2021/6/25

Y1 - 2021/6/25

N2 - Arterial blood pressure is one of the most often measured vital parameters in clinical practice. State-of-the-art noninvasive ABP measurement technologies have noticeable limitations and are mainly based on uncomfortable techniques of complete or partial arterial occlusion by cuffs. Most commonplace devices provide only intermittent measurements, and continuous systems are bulky and difficult to apply correctly for nonprofessionals. Continuous cuffless ABP measurements are still an unmet clinical need and a topic of ongoing research, with only few commercially available devices. This paper discusses surrogate-based noninvasive blood pressure measurement techniques. It covers measurement methods of continuously and noninvasively inferring BP from surrogate signals without applying external pressures, except for reference or initialization purposes. The BP is estimated by processing signal features, so called surrogates, which are modulated by variations of BP. Discussed techniques include well-known approaches such as pulse transit time and pulse arrival time techniques, pulse wave analysis or combinations thereof. Despite a long research history, these methods have not found widespread use in clinical and ambulatory practice, in part due to technical limitations and the lack of a standardized regulatory framework. This work summarizes findings from an invited workshop of experts in the fields covering clinical expertise, engineering aspects, commercialization and standardization issues. The goal is to provide an application driven outlook, starting with clinical needs, and extending to technical actuality. It provides an outline of recommended research directions and includes a detailed overview of clinical use case scenarios for these technologies, opportunities, and limitations.

AB - Arterial blood pressure is one of the most often measured vital parameters in clinical practice. State-of-the-art noninvasive ABP measurement technologies have noticeable limitations and are mainly based on uncomfortable techniques of complete or partial arterial occlusion by cuffs. Most commonplace devices provide only intermittent measurements, and continuous systems are bulky and difficult to apply correctly for nonprofessionals. Continuous cuffless ABP measurements are still an unmet clinical need and a topic of ongoing research, with only few commercially available devices. This paper discusses surrogate-based noninvasive blood pressure measurement techniques. It covers measurement methods of continuously and noninvasively inferring BP from surrogate signals without applying external pressures, except for reference or initialization purposes. The BP is estimated by processing signal features, so called surrogates, which are modulated by variations of BP. Discussed techniques include well-known approaches such as pulse transit time and pulse arrival time techniques, pulse wave analysis or combinations thereof. Despite a long research history, these methods have not found widespread use in clinical and ambulatory practice, in part due to technical limitations and the lack of a standardized regulatory framework. This work summarizes findings from an invited workshop of experts in the fields covering clinical expertise, engineering aspects, commercialization and standardization issues. The goal is to provide an application driven outlook, starting with clinical needs, and extending to technical actuality. It provides an outline of recommended research directions and includes a detailed overview of clinical use case scenarios for these technologies, opportunities, and limitations.

KW - Blood Pressure/physiology

KW - Blood Pressure Determination/methods

KW - Humans

KW - Pulse Wave Analysis/instrumentation

KW - Signal Processing, Computer-Assisted

U2 - 10.1515/bmt-2020-0209

DO - 10.1515/bmt-2020-0209

M3 - SCORING: Review article

C2 - 33565285

VL - 66

SP - 231

EP - 245

JO - BIOMED ENG-BIOMED TE

JF - BIOMED ENG-BIOMED TE

SN - 0013-5585

IS - 3

ER -