Surgery for atypical plexiform neurofibromas of the trunk in NF1 with high standardised uptake value (SUV) in positron-emission tomography (PET) expressing podoplanin: a long-term follow-up.
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Surgery for atypical plexiform neurofibromas of the trunk in NF1 with high standardised uptake value (SUV) in positron-emission tomography (PET) expressing podoplanin: a long-term follow-up. / Friedrich, Reinhard; Gawad, Karim; Derlin, Thorsten; Zustin, Jozef; Hagel, Christian.
In: ANTICANCER RES, Vol. 32, No. 10, 10, 01.10.2012, p. 4547-4551.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Surgery for atypical plexiform neurofibromas of the trunk in NF1 with high standardised uptake value (SUV) in positron-emission tomography (PET) expressing podoplanin: a long-term follow-up.
AU - Friedrich, Reinhard
AU - Gawad, Karim
AU - Derlin, Thorsten
AU - Zustin, Jozef
AU - Hagel, Christian
PY - 2012/10/1
Y1 - 2012/10/1
N2 - A 23-year-old female with an established diagnosis of neurofibromatosis type 1 (NF1) was found to have two tumours in her trunk. These showed high uptake value in positron-emission/computerized tomography (PET) scans, and were suspected to be malignant peripheral nerve sheath tumours (MPNST). The extirpated tumours proved to be atypical plexiform neurofibromas. Slight to moderate podoplanin expression of the tumour cells was noted in areas of fibrillary growth. Six years following surgery, there is neither evidence of local tumour recurrence nor development of MPNST. Current studies on atypical neurofibroma in NF1 suggest podoplanin expression in subtypes of transformed Schwann cells, resembling schwannoma-like areas in neurofibroma. This marker may be useful in distinguishing different Schwann cell populations in NF1.
AB - A 23-year-old female with an established diagnosis of neurofibromatosis type 1 (NF1) was found to have two tumours in her trunk. These showed high uptake value in positron-emission/computerized tomography (PET) scans, and were suspected to be malignant peripheral nerve sheath tumours (MPNST). The extirpated tumours proved to be atypical plexiform neurofibromas. Slight to moderate podoplanin expression of the tumour cells was noted in areas of fibrillary growth. Six years following surgery, there is neither evidence of local tumour recurrence nor development of MPNST. Current studies on atypical neurofibroma in NF1 suggest podoplanin expression in subtypes of transformed Schwann cells, resembling schwannoma-like areas in neurofibroma. This marker may be useful in distinguishing different Schwann cell populations in NF1.
KW - Humans
KW - Female
KW - Young Adult
KW - Follow-Up Studies
KW - Disease-Free Survival
KW - Positron-Emission Tomography
KW - Tumor Markers, Biological/analysis
KW - Ki-67 Antigen/analysis
KW - Radiopharmaceuticals/diagnostic use
KW - Fluorodeoxyglucose F18/diagnostic use
KW - Membrane Glycoproteins/analysis/biosynthesis
KW - Mucin-1/analysis
KW - Nerve Sheath Neoplasms/chemistry/diagnosis/surgery
KW - Neurofibroma, Plexiform/chemistry/diagnosis/surgery
KW - Neurofibromatosis 1/diagnosis/surgery
KW - S100 Proteins/analysis
KW - Humans
KW - Female
KW - Young Adult
KW - Follow-Up Studies
KW - Disease-Free Survival
KW - Positron-Emission Tomography
KW - Tumor Markers, Biological/analysis
KW - Ki-67 Antigen/analysis
KW - Radiopharmaceuticals/diagnostic use
KW - Fluorodeoxyglucose F18/diagnostic use
KW - Membrane Glycoproteins/analysis/biosynthesis
KW - Mucin-1/analysis
KW - Nerve Sheath Neoplasms/chemistry/diagnosis/surgery
KW - Neurofibroma, Plexiform/chemistry/diagnosis/surgery
KW - Neurofibromatosis 1/diagnosis/surgery
KW - S100 Proteins/analysis
M3 - SCORING: Journal article
C2 - 23060584
VL - 32
SP - 4547
EP - 4551
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 10
M1 - 10
ER -
