Supervised exercise training in patients with advanced heart failure and left ventricular assist device: A multicentre randomized controlled trial (Ex-VAD trial)
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Supervised exercise training in patients with advanced heart failure and left ventricular assist device: A multicentre randomized controlled trial (Ex-VAD trial). / Feuerstein, Anna; Schoenrath, Felix; Belyavskiy, Evgeny; Knierim, Jan; Friede, Tim; Placzek, Marius; Bach, Doris; Pieske-Kraigher, Elisabeth; Herrmann-Lingen, Christoph; Westenfeld, Ralf; Roden, Michael; Rybczynski, Meike; Verheyen, Nicolas; Dörr, Marcus; von Haehling, Stephan; Störk, Stefan; Halle, Martin; Falk, Volkmar; Pieske, Burkert; Edelmann, Frank.
In: EUR J HEART FAIL, Vol. 25, No. 12, 12.2023, p. 2252-2262.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Supervised exercise training in patients with advanced heart failure and left ventricular assist device: A multicentre randomized controlled trial (Ex-VAD trial)
AU - Feuerstein, Anna
AU - Schoenrath, Felix
AU - Belyavskiy, Evgeny
AU - Knierim, Jan
AU - Friede, Tim
AU - Placzek, Marius
AU - Bach, Doris
AU - Pieske-Kraigher, Elisabeth
AU - Herrmann-Lingen, Christoph
AU - Westenfeld, Ralf
AU - Roden, Michael
AU - Rybczynski, Meike
AU - Verheyen, Nicolas
AU - Dörr, Marcus
AU - von Haehling, Stephan
AU - Störk, Stefan
AU - Halle, Martin
AU - Falk, Volkmar
AU - Pieske, Burkert
AU - Edelmann, Frank
N1 - © 2023 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
PY - 2023/12
Y1 - 2023/12
N2 - AIMS: Small studies and observations suggested that exercise training may improve peak oxygen consumption (peakVO2 ) in patients with advanced heart failure and left ventricular assist device (LVAD). We investigated whether in this patient group a supervised exercise training can improve exercise capacity.METHODS AND RESULTS: In this multicentre, prospective, randomized, controlled trial, patients with stable heart failure and LVAD were randomly assigned (2:1) to 12 weeks of supervised exercise training or usual care, with 12 weeks of follow-up. The primary endpoint was the change in peakVO2 after 12 weeks (51 patients provided a power of 90% with an expected group difference in peakVO2 of 3 ml/kg/min). Secondary endpoints included changes in submaximal exercise capacity and quality of life. Among 64 patients enrolled (97% male, mean age 56 years), 54 were included in the analysis. Mean difference in the change of peakVO2 after 12 weeks was 0.826 ml/min/kg (95% confidence interval [CI] -0.37, 2.03; p = 0.183). There was a positive effect of exercise training on 6-min walk distance with a mean increase in the intervention group by 43.4 m (95% CI 16.9, 69.9; p = 0.0024), and on the Kansas City Cardiomyopathy Questionnaire physical domain score (mean 14.3, 95% CI 3.7, 24.9; p = 0.0124), both after 12 weeks. The overall adherence was high (71%), and there were no differences in adverse events between groups.CONCLUSION: In patients with advanced heart failure and LVAD, 12 weeks of exercise training did not improve peakVO2 but demonstrated positive effects on submaximal exercise capacity and physical quality of life.
AB - AIMS: Small studies and observations suggested that exercise training may improve peak oxygen consumption (peakVO2 ) in patients with advanced heart failure and left ventricular assist device (LVAD). We investigated whether in this patient group a supervised exercise training can improve exercise capacity.METHODS AND RESULTS: In this multicentre, prospective, randomized, controlled trial, patients with stable heart failure and LVAD were randomly assigned (2:1) to 12 weeks of supervised exercise training or usual care, with 12 weeks of follow-up. The primary endpoint was the change in peakVO2 after 12 weeks (51 patients provided a power of 90% with an expected group difference in peakVO2 of 3 ml/kg/min). Secondary endpoints included changes in submaximal exercise capacity and quality of life. Among 64 patients enrolled (97% male, mean age 56 years), 54 were included in the analysis. Mean difference in the change of peakVO2 after 12 weeks was 0.826 ml/min/kg (95% confidence interval [CI] -0.37, 2.03; p = 0.183). There was a positive effect of exercise training on 6-min walk distance with a mean increase in the intervention group by 43.4 m (95% CI 16.9, 69.9; p = 0.0024), and on the Kansas City Cardiomyopathy Questionnaire physical domain score (mean 14.3, 95% CI 3.7, 24.9; p = 0.0124), both after 12 weeks. The overall adherence was high (71%), and there were no differences in adverse events between groups.CONCLUSION: In patients with advanced heart failure and LVAD, 12 weeks of exercise training did not improve peakVO2 but demonstrated positive effects on submaximal exercise capacity and physical quality of life.
KW - Humans
KW - Male
KW - Middle Aged
KW - Female
KW - Heart Failure/therapy
KW - Quality of Life
KW - Heart-Assist Devices
KW - Prospective Studies
KW - Exercise Tolerance
KW - Exercise
U2 - 10.1002/ejhf.3032
DO - 10.1002/ejhf.3032
M3 - SCORING: Journal article
C2 - 37702315
VL - 25
SP - 2252
EP - 2262
JO - EUR J HEART FAIL
JF - EUR J HEART FAIL
SN - 1388-9842
IS - 12
ER -
