Sulfatide-mediated activation of type II natural killer T cells prevents hepatic ischemic reperfusion injury in mice.
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Sulfatide-mediated activation of type II natural killer T cells prevents hepatic ischemic reperfusion injury in mice. / Arrenberg, Philomena; Maricic, Igor; Kumar, Vipin.
In: GASTROENTEROLOGY, Vol. 140, No. 2, 2, 2011, p. 646-655.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Sulfatide-mediated activation of type II natural killer T cells prevents hepatic ischemic reperfusion injury in mice.
AU - Arrenberg, Philomena
AU - Maricic, Igor
AU - Kumar, Vipin
PY - 2011
Y1 - 2011
N2 - Hepatic ischemic reperfusion injury (IRI) is a major complication of liver transplantation and resectional hepatic surgeries. Natural killer T (NKT) cells predominate in liver, where they recognize lipid antigens bound to CD1d molecules. Type I NKT cells use a semi-invariant T-cell receptor and react with -galactosylceramide; type II NKT cells use diverse T-cell receptors. Some type II NKT cells recognize the self-glycolipid sulfatide. It is not clear whether or how these distinct NKT cell subsets mediate hepatocellular damage after IRI.
AB - Hepatic ischemic reperfusion injury (IRI) is a major complication of liver transplantation and resectional hepatic surgeries. Natural killer T (NKT) cells predominate in liver, where they recognize lipid antigens bound to CD1d molecules. Type I NKT cells use a semi-invariant T-cell receptor and react with -galactosylceramide; type II NKT cells use diverse T-cell receptors. Some type II NKT cells recognize the self-glycolipid sulfatide. It is not clear whether or how these distinct NKT cell subsets mediate hepatocellular damage after IRI.
M3 - SCORING: Zeitschriftenaufsatz
VL - 140
SP - 646
EP - 655
JO - GASTROENTEROLOGY
JF - GASTROENTEROLOGY
SN - 0016-5085
IS - 2
M1 - 2
ER -
