Suicide and accidental deaths among patients with non-metastatic prostate cancer
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Suicide and accidental deaths among patients with non-metastatic prostate cancer. / Dalela, Deepansh; Krishna, Nandita; Okwara, James; Preston, Mark A; Abdollah, Firas; Choueiri, Toni K; Reznor, Gally; Sammon, Jesse D; Schmid, Marianne; Kibel, Adam S; Nguyen, Paul L; Menon, Mani; Trinh, Quoc-Dien.
In: BJU INT, Vol. 118, No. 2, 08.2016, p. 286-97.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Suicide and accidental deaths among patients with non-metastatic prostate cancer
AU - Dalela, Deepansh
AU - Krishna, Nandita
AU - Okwara, James
AU - Preston, Mark A
AU - Abdollah, Firas
AU - Choueiri, Toni K
AU - Reznor, Gally
AU - Sammon, Jesse D
AU - Schmid, Marianne
AU - Kibel, Adam S
AU - Nguyen, Paul L
AU - Menon, Mani
AU - Trinh, Quoc-Dien
N1 - © 2015 The Authors BJU International © 2015 BJU International Published by John Wiley & Sons Ltd.
PY - 2016/8
Y1 - 2016/8
N2 - OBJECTIVE: To determine if American men with prostate cancer are at increased risk of suicide/accidental death compared with other cancers and if the receipt of definitive treatment alters this association, as patients with cancer are at increased risk of suicide and evidence suggests a relationship between suicides and deaths due to accidents and externally caused injuries.PATIENTS AND METHODS: Demographic, socio-economic and tumour characteristics of men with prostate cancer and men with other solid malignancies were extracted from the Surveillance, Epidemiology and End Results (SEER) database (1988-2010). Poisson regression models were fitted to compare the incidence of suicidal and accidental deaths in prostate cancer vs other solid cancers. Multivariate Cox regression was used to determine if receipt of definitive primary treatment impacted the risk of suicide or accidental death in men with localised/regional prostate cancer.RESULTS: Risk of suicidal and accidental death was significantly lower in men with prostate cancer (1 165 [0.2%] and 3 199 [0.6%]) than men with other cancers (2 232 [0.2%] and 4 501 [0.5%], respectively), except within the first year of diagnosis (adjusted relative risk [ARR] 3.98, 95% confidence interval [CI] 3.02-5.23 and ARR 4.22, 95% CI 3.24-5.51, respectively, 0-3 months after diagnosis). Men with non-metastatic prostate cancer who were White, uninsured, or recommended but did not receive treatment (hazard ratio vs treated 1.44, 95% CI 1.20-1.72, and 1.44, 95% CI 1.30-1.59, both P < 0.001) were at increased risk of suicidal and accidental mortality, respectively. Absence of data about previous co-morbidities and drug addictions in the SEER dataset was an important limitation.CONCLUSIONS: Relative to other cancers, men with prostate cancer were at increased risk of suicide and accidental deaths within the first year of diagnosis and when definitive treatment was recommended but not received, suggesting the need for close monitoring and coordination with mental health professionals in at-risk men with potentially curable disease.
AB - OBJECTIVE: To determine if American men with prostate cancer are at increased risk of suicide/accidental death compared with other cancers and if the receipt of definitive treatment alters this association, as patients with cancer are at increased risk of suicide and evidence suggests a relationship between suicides and deaths due to accidents and externally caused injuries.PATIENTS AND METHODS: Demographic, socio-economic and tumour characteristics of men with prostate cancer and men with other solid malignancies were extracted from the Surveillance, Epidemiology and End Results (SEER) database (1988-2010). Poisson regression models were fitted to compare the incidence of suicidal and accidental deaths in prostate cancer vs other solid cancers. Multivariate Cox regression was used to determine if receipt of definitive primary treatment impacted the risk of suicide or accidental death in men with localised/regional prostate cancer.RESULTS: Risk of suicidal and accidental death was significantly lower in men with prostate cancer (1 165 [0.2%] and 3 199 [0.6%]) than men with other cancers (2 232 [0.2%] and 4 501 [0.5%], respectively), except within the first year of diagnosis (adjusted relative risk [ARR] 3.98, 95% confidence interval [CI] 3.02-5.23 and ARR 4.22, 95% CI 3.24-5.51, respectively, 0-3 months after diagnosis). Men with non-metastatic prostate cancer who were White, uninsured, or recommended but did not receive treatment (hazard ratio vs treated 1.44, 95% CI 1.20-1.72, and 1.44, 95% CI 1.30-1.59, both P < 0.001) were at increased risk of suicidal and accidental mortality, respectively. Absence of data about previous co-morbidities and drug addictions in the SEER dataset was an important limitation.CONCLUSIONS: Relative to other cancers, men with prostate cancer were at increased risk of suicide and accidental deaths within the first year of diagnosis and when definitive treatment was recommended but not received, suggesting the need for close monitoring and coordination with mental health professionals in at-risk men with potentially curable disease.
KW - Accidents
KW - Adult
KW - Aged
KW - Humans
KW - Male
KW - Middle Aged
KW - Prostatic Neoplasms
KW - Risk Assessment
KW - Suicide
KW - Comparative Study
KW - Journal Article
U2 - 10.1111/bju.13257
DO - 10.1111/bju.13257
M3 - SCORING: Journal article
C2 - 26305451
VL - 118
SP - 286
EP - 297
JO - BJU INT
JF - BJU INT
SN - 1464-4096
IS - 2
ER -
