Research ExplorerPublicationsSudden cardiac arrest associated with early repolarization

Sudden cardiac arrest associated with early repolarization

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Sudden cardiac arrest associated with early repolarization. / Haïssaguerre, Michel; Derval, Nicolas; Sacher, Frederic; Jesel, Laurence; Deisenhofer, Isabel; de Roy, Luc; Pasquié, Jean-Luc; Nogami, Akihiko; Babuty, Dominique; Yli-Mayry, Sinikka; De Chillou, Christian; Scanu, Patrice; Mabo, Philippe; Matsuo, Seiichiro; Probst, Vincent; Le Scouarnec, Solena; Defaye, Pascal; Schlaepfer, Juerg; Rostock, Thomas; Lacroix, Dominique; Lamaison, Dominique; Lavergne, Thomas; Aizawa, Yoshifusa; Englund, Anders; Anselme, Frederic; O'Neill, Mark; Hocini, Meleze; Lim, Kang Teng; Knecht, Sebastien; Veenhuyzen, George D; Bordachar, Pierre; Chauvin, Michel; Jais, Pierre; Coureau, Gaelle; Chene, Genevieve; Klein, George J; Clémenty, Jacques.

In: NEW ENGL J MED, Vol. 358, No. 19, 08.05.2008, p. 2016-2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Haïssaguerre, M, Derval, N, Sacher, F, Jesel, L, Deisenhofer, I, de Roy, L, Pasquié, J-L, Nogami, A, Babuty, D, Yli-Mayry, S, De Chillou, C, Scanu, P, Mabo, P, Matsuo, S, Probst, V, Le Scouarnec, S, Defaye, P, Schlaepfer, J, Rostock, T, Lacroix, D, Lamaison, D, Lavergne, T, Aizawa, Y, Englund, A, Anselme, F, O'Neill, M, Hocini, M, Lim, KT, Knecht, S, Veenhuyzen, GD, Bordachar, P, Chauvin, M, Jais, P, Coureau, G, Chene, G, Klein, GJ & Clémenty, J 2008, 'Sudden cardiac arrest associated with early repolarization', NEW ENGL J MED, vol. 358, no. 19, pp. 2016-2023. https://doi.org/10.1056/NEJMoa071968

APA

Haïssaguerre, M., Derval, N., Sacher, F., Jesel, L., Deisenhofer, I., de Roy, L., Pasquié, J-L., Nogami, A., Babuty, D., Yli-Mayry, S., De Chillou, C., Scanu, P., Mabo, P., Matsuo, S., Probst, V., Le Scouarnec, S., Defaye, P., Schlaepfer, J., Rostock, T., ... Clémenty, J. (2008). Sudden cardiac arrest associated with early repolarization. NEW ENGL J MED, 358(19), 2016-2023. https://doi.org/10.1056/NEJMoa071968

Vancouver

Haïssaguerre M, Derval N, Sacher F, Jesel L, Deisenhofer I, de Roy L et al. Sudden cardiac arrest associated with early repolarization. NEW ENGL J MED. 2008 May 8;358(19):2016-2023. https://doi.org/10.1056/NEJMoa071968

Bibtex

@article{e53e4bc3bb4a4332a9d0d4b607c8090c,
title = "Sudden cardiac arrest associated with early repolarization",
abstract = "BACKGROUND: Early repolarization is a common electrocardiographic finding that is generally considered to be benign. Its potential to cause cardiac arrhythmias has been hypothesized from experimental studies, but it is not known whether there is a clinical association with sudden cardiac arrest.METHODS: We reviewed data from 206 case subjects at 22 centers who were resuscitated after cardiac arrest due to idiopathic ventricular fibrillation and assessed the prevalence of electrocardiographic early repolarization. The latter was defined as an elevation of the QRS-ST junction of at least 0.1 mV from baseline in the inferior or lateral lead, manifested as QRS slurring or notching. The control group comprised 412 subjects without heart disease who were matched for age, sex, race, and level of physical activity. Follow-up data that included the results of monitoring with an implantable defibrillator were obtained for all case subjects.RESULTS: Early repolarization was more frequent in case subjects with idiopathic ventricular fibrillation than in control subjects (31% vs. 5%, P<0.001). Among case subjects, those with early repolarization were more likely to be male and to have a history of syncope or sudden cardiac arrest during sleep than those without early repolarization. In eight subjects, the origin of ectopy that initiated ventricular arrhythmias was mapped to sites concordant with the localization of repolarization abnormalities. During a mean (+/-SD) follow-up of 61+/-50 months, defibrillator monitoring showed a higher incidence of recurrent ventricular fibrillation in case subjects with a repolarization abnormality than in those without such an abnormality (hazard ratio, 2.1; 95% confidence interval, 1.2 to 3.5; P=0.008).CONCLUSIONS: Among patients with a history of idiopathic ventricular fibrillation, there is an increased prevalence of early repolarization.",
keywords = "Actuarial Analysis, Adult, Anti-Arrhythmia Agents/therapeutic use, Arrhythmias, Cardiac/epidemiology, Cardiac Electrophysiology, Case-Control Studies, Catheter Ablation, Death, Sudden, Cardiac/etiology, Defibrillators, Implantable, Electrocardiography, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prevalence, Recurrence, Statistics, Nonparametric, Ventricular Fibrillation/complications",
author = "Michel Ha{\"i}ssaguerre and Nicolas Derval and Frederic Sacher and Laurence Jesel and Isabel Deisenhofer and {de Roy}, Luc and Jean-Luc Pasqui{\'e} and Akihiko Nogami and Dominique Babuty and Sinikka Yli-Mayry and {De Chillou}, Christian and Patrice Scanu and Philippe Mabo and Seiichiro Matsuo and Vincent Probst and {Le Scouarnec}, Solena and Pascal Defaye and Juerg Schlaepfer and Thomas Rostock and Dominique Lacroix and Dominique Lamaison and Thomas Lavergne and Yoshifusa Aizawa and Anders Englund and Frederic Anselme and Mark O'Neill and Meleze Hocini and Lim, {Kang Teng} and Sebastien Knecht and Veenhuyzen, {George D} and Pierre Bordachar and Michel Chauvin and Pierre Jais and Gaelle Coureau and Genevieve Chene and Klein, {George J} and Jacques Cl{\'e}menty",
note = "Copyright 2008 Massachusetts Medical Society.",
year = "2008",
month = may,
day = "8",
doi = "10.1056/NEJMoa071968",
language = "English",
volume = "358",
pages = "2016--2023",
journal = "NEW ENGL J MED",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "19",

}

RIS

TY - JOUR

T1 - Sudden cardiac arrest associated with early repolarization

AU - Haïssaguerre, Michel

AU - Derval, Nicolas

AU - Sacher, Frederic

AU - Jesel, Laurence

AU - Deisenhofer, Isabel

AU - de Roy, Luc

AU - Pasquié, Jean-Luc

AU - Nogami, Akihiko

AU - Babuty, Dominique

AU - Yli-Mayry, Sinikka

AU - De Chillou, Christian

AU - Scanu, Patrice

AU - Mabo, Philippe

AU - Matsuo, Seiichiro

AU - Probst, Vincent

AU - Le Scouarnec, Solena

AU - Defaye, Pascal

AU - Schlaepfer, Juerg

AU - Rostock, Thomas

AU - Lacroix, Dominique

AU - Lamaison, Dominique

AU - Lavergne, Thomas

AU - Aizawa, Yoshifusa

AU - Englund, Anders

AU - Anselme, Frederic

AU - O'Neill, Mark

AU - Hocini, Meleze

AU - Lim, Kang Teng

AU - Knecht, Sebastien

AU - Veenhuyzen, George D

AU - Bordachar, Pierre

AU - Chauvin, Michel

AU - Jais, Pierre

AU - Coureau, Gaelle

AU - Chene, Genevieve

AU - Klein, George J

AU - Clémenty, Jacques

N1 - Copyright 2008 Massachusetts Medical Society.

PY - 2008/5/8

Y1 - 2008/5/8

N2 - BACKGROUND: Early repolarization is a common electrocardiographic finding that is generally considered to be benign. Its potential to cause cardiac arrhythmias has been hypothesized from experimental studies, but it is not known whether there is a clinical association with sudden cardiac arrest.METHODS: We reviewed data from 206 case subjects at 22 centers who were resuscitated after cardiac arrest due to idiopathic ventricular fibrillation and assessed the prevalence of electrocardiographic early repolarization. The latter was defined as an elevation of the QRS-ST junction of at least 0.1 mV from baseline in the inferior or lateral lead, manifested as QRS slurring or notching. The control group comprised 412 subjects without heart disease who were matched for age, sex, race, and level of physical activity. Follow-up data that included the results of monitoring with an implantable defibrillator were obtained for all case subjects.RESULTS: Early repolarization was more frequent in case subjects with idiopathic ventricular fibrillation than in control subjects (31% vs. 5%, P<0.001). Among case subjects, those with early repolarization were more likely to be male and to have a history of syncope or sudden cardiac arrest during sleep than those without early repolarization. In eight subjects, the origin of ectopy that initiated ventricular arrhythmias was mapped to sites concordant with the localization of repolarization abnormalities. During a mean (+/-SD) follow-up of 61+/-50 months, defibrillator monitoring showed a higher incidence of recurrent ventricular fibrillation in case subjects with a repolarization abnormality than in those without such an abnormality (hazard ratio, 2.1; 95% confidence interval, 1.2 to 3.5; P=0.008).CONCLUSIONS: Among patients with a history of idiopathic ventricular fibrillation, there is an increased prevalence of early repolarization.

AB - BACKGROUND: Early repolarization is a common electrocardiographic finding that is generally considered to be benign. Its potential to cause cardiac arrhythmias has been hypothesized from experimental studies, but it is not known whether there is a clinical association with sudden cardiac arrest.METHODS: We reviewed data from 206 case subjects at 22 centers who were resuscitated after cardiac arrest due to idiopathic ventricular fibrillation and assessed the prevalence of electrocardiographic early repolarization. The latter was defined as an elevation of the QRS-ST junction of at least 0.1 mV from baseline in the inferior or lateral lead, manifested as QRS slurring or notching. The control group comprised 412 subjects without heart disease who were matched for age, sex, race, and level of physical activity. Follow-up data that included the results of monitoring with an implantable defibrillator were obtained for all case subjects.RESULTS: Early repolarization was more frequent in case subjects with idiopathic ventricular fibrillation than in control subjects (31% vs. 5%, P<0.001). Among case subjects, those with early repolarization were more likely to be male and to have a history of syncope or sudden cardiac arrest during sleep than those without early repolarization. In eight subjects, the origin of ectopy that initiated ventricular arrhythmias was mapped to sites concordant with the localization of repolarization abnormalities. During a mean (+/-SD) follow-up of 61+/-50 months, defibrillator monitoring showed a higher incidence of recurrent ventricular fibrillation in case subjects with a repolarization abnormality than in those without such an abnormality (hazard ratio, 2.1; 95% confidence interval, 1.2 to 3.5; P=0.008).CONCLUSIONS: Among patients with a history of idiopathic ventricular fibrillation, there is an increased prevalence of early repolarization.

KW - Actuarial Analysis

KW - Adult

KW - Anti-Arrhythmia Agents/therapeutic use

KW - Arrhythmias, Cardiac/epidemiology

KW - Cardiac Electrophysiology

KW - Case-Control Studies

KW - Catheter Ablation

KW - Death, Sudden, Cardiac/etiology

KW - Defibrillators, Implantable

KW - Electrocardiography

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Recurrence

KW - Statistics, Nonparametric

KW - Ventricular Fibrillation/complications

U2 - 10.1056/NEJMoa071968

DO - 10.1056/NEJMoa071968

M3 - SCORING: Journal article

C2 - 18463377

VL - 358

SP - 2016

EP - 2023

JO - NEW ENGL J MED

JF - NEW ENGL J MED

SN - 0028-4793

IS - 19

ER -