Subthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement.
Standard
Subthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement. / Weiss, Daniel; Breit, Sorin; Hoppe, Julia; Hauser, Ann-Kathrin; Freudenstein, Dirk; Krüger, Rejko; Sauseng, Paul; Govindan, Rathinaswamy B; Gerloff, Christian.
In: EUR J NEUROSCI, Vol. 35, No. 6, 6, 2012, p. 896-908.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Subthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement.
AU - Weiss, Daniel
AU - Breit, Sorin
AU - Hoppe, Julia
AU - Hauser, Ann-Kathrin
AU - Freudenstein, Dirk
AU - Krüger, Rejko
AU - Sauseng, Paul
AU - Govindan, Rathinaswamy B
AU - Gerloff, Christian
PY - 2012
Y1 - 2012
N2 - Pathological synchronization in large-scale motor networks constitutes a pathophysiological hallmark of Parkinson's disease (PD). Corticomuscular synchronization in PD is pronounced in lower frequency bands (<10 Hz), whereas efficient cortical motor integration in healthy persons is driven in the beta frequency range. Electroencephalogram and electromyogram recordings at rest and during an isometric precision grip task were performed in four perioperative sessions in 10 patients with PD undergoing subthalamic nucleus deep-brain stimulation: (i) 1 day before (D0); (ii) 1 day after (D1); (iii) 8 days after implantation of macroelectrodes with stimulation off (D8StimOff); and (iv) on (D8StimOn). Analyses of coherence and phase delays were performed in order to challenge the effects of microlesion and stimulation on corticomuscular coherence (CMC). Additionally, local field potentials recorded from the subthalamic nucleus on D1 allowed comprehensive mapping of motor-related synchronization in subthalamocortical and cerebromuscular networks. Motor performance improved at D8StimOn compared with D0 and D8StimOff paralleled by a reduction of muscular activity and CMC in the theta band (3.9-7.8 Hz) and by an increase of CMC in the low-beta band (13.7-19.5 Hz). Efferent motor cortical drives to muscle presented mainly below 10 Hz on D8StimOff that were suppressed on D8StimOn and occurred on higher frequencies from 13 to 45 Hz. On D1, coherence of the high-beta band (20.5-30.2 Hz) increased during movement compared with rest in subthalamomuscular and corticomuscular projections, whereas it was attenuated in subcorticocortical projections. The present findings lend further support to the concept of pathological network synchronization in PD that is beneficially modulated by stimulation.
AB - Pathological synchronization in large-scale motor networks constitutes a pathophysiological hallmark of Parkinson's disease (PD). Corticomuscular synchronization in PD is pronounced in lower frequency bands (<10 Hz), whereas efficient cortical motor integration in healthy persons is driven in the beta frequency range. Electroencephalogram and electromyogram recordings at rest and during an isometric precision grip task were performed in four perioperative sessions in 10 patients with PD undergoing subthalamic nucleus deep-brain stimulation: (i) 1 day before (D0); (ii) 1 day after (D1); (iii) 8 days after implantation of macroelectrodes with stimulation off (D8StimOff); and (iv) on (D8StimOn). Analyses of coherence and phase delays were performed in order to challenge the effects of microlesion and stimulation on corticomuscular coherence (CMC). Additionally, local field potentials recorded from the subthalamic nucleus on D1 allowed comprehensive mapping of motor-related synchronization in subthalamocortical and cerebromuscular networks. Motor performance improved at D8StimOn compared with D0 and D8StimOff paralleled by a reduction of muscular activity and CMC in the theta band (3.9-7.8 Hz) and by an increase of CMC in the low-beta band (13.7-19.5 Hz). Efferent motor cortical drives to muscle presented mainly below 10 Hz on D8StimOff that were suppressed on D8StimOn and occurred on higher frequencies from 13 to 45 Hz. On D1, coherence of the high-beta band (20.5-30.2 Hz) increased during movement compared with rest in subthalamomuscular and corticomuscular projections, whereas it was attenuated in subcorticocortical projections. The present findings lend further support to the concept of pathological network synchronization in PD that is beneficially modulated by stimulation.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Signal Processing, Computer-Assisted
KW - Psychomotor Performance/physiology
KW - Motor Cortex/physiopathology
KW - Cortical Synchronization/physiology
KW - Deep Brain Stimulation
KW - Muscle, Skeletal/innervation
KW - Parkinson Disease/physiopathology/therapy
KW - Subthalamic Nucleus/physiopathology
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Signal Processing, Computer-Assisted
KW - Psychomotor Performance/physiology
KW - Motor Cortex/physiopathology
KW - Cortical Synchronization/physiology
KW - Deep Brain Stimulation
KW - Muscle, Skeletal/innervation
KW - Parkinson Disease/physiopathology/therapy
KW - Subthalamic Nucleus/physiopathology
M3 - SCORING: Journal article
VL - 35
SP - 896
EP - 908
JO - EUR J NEUROSCI
JF - EUR J NEUROSCI
SN - 0953-816X
IS - 6
M1 - 6
ER -
