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Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome.

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Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome. / Godau, Jana; Schweitzer, Katherine J; Liepelt, Inga; Gerloff, Christian; Berg, Daniela.

In: MOVEMENT DISORD, Vol. 22, No. 2, 2, 2007, p. 187-192.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Godau, J, Schweitzer, KJ, Liepelt, I, Gerloff, C & Berg, D 2007, 'Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome.', MOVEMENT DISORD, vol. 22, no. 2, 2, pp. 187-192. <http://www.ncbi.nlm.nih.gov/pubmed/17133515?dopt=Citation>

APA

Godau, J., Schweitzer, K. J., Liepelt, I., Gerloff, C., & Berg, D. (2007). Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome. MOVEMENT DISORD, 22(2), 187-192. [2]. http://www.ncbi.nlm.nih.gov/pubmed/17133515?dopt=Citation

Vancouver

Godau J, Schweitzer KJ, Liepelt I, Gerloff C, Berg D. Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome. MOVEMENT DISORD. 2007;22(2):187-192. 2.

Bibtex

@article{d423831076464417a818ed2c413865f1,
title = "Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome.",
abstract = "Pathological studies demonstrate a decreased iron content in the substantia nigra (SN) contributing to the pathophysiology of restless legs syndrome (RLS). SN echogenicity as measured by transcranial sonography (TCS) correlates with the SN iron content. The objective of this study was to determine a critical value to define SN hypoechogenicity as a potential marker for RLS. There were 49 RLS patients (39 idiopathic, 10 secondary) and 49 age- and sex-matched controls who underwent TCS by 2 independent and blinded examiners to determine the area of SN echogenicity. We found that SN echogenicity is significantly decreased in RLS patients compared to healthy controls (P <0.001). SN hypoechogenicity (sum area of SN echogenicity of both sides <0.2 cm(2)) is more common in idiopathic than in secondary RLS patients. The area under curve for idiopathic RLS versus controls (receiver operating characteristics) is 0.91, specificity is 0.90, and sensitivity is 0.82. TCS provides an interesting additional instrument in the diagnosis of RLS. Therefore, SN hypoechogenicity (SN sum area <0.2 cm(2)), which is supposed to indicate a decreased SN iron content, is a marker for RLS. Further studies are needed to investigate its significance for the pathophysiology of this frequent movement disorder and possible clinical applications.",
author = "Jana Godau and Schweitzer, {Katherine J} and Inga Liepelt and Christian Gerloff and Daniela Berg",
year = "2007",
language = "English",
volume = "22",
pages = "187--192",
journal = "MOVEMENT DISORD",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome.

AU - Godau, Jana

AU - Schweitzer, Katherine J

AU - Liepelt, Inga

AU - Gerloff, Christian

AU - Berg, Daniela

PY - 2007

Y1 - 2007

N2 - Pathological studies demonstrate a decreased iron content in the substantia nigra (SN) contributing to the pathophysiology of restless legs syndrome (RLS). SN echogenicity as measured by transcranial sonography (TCS) correlates with the SN iron content. The objective of this study was to determine a critical value to define SN hypoechogenicity as a potential marker for RLS. There were 49 RLS patients (39 idiopathic, 10 secondary) and 49 age- and sex-matched controls who underwent TCS by 2 independent and blinded examiners to determine the area of SN echogenicity. We found that SN echogenicity is significantly decreased in RLS patients compared to healthy controls (P <0.001). SN hypoechogenicity (sum area of SN echogenicity of both sides <0.2 cm(2)) is more common in idiopathic than in secondary RLS patients. The area under curve for idiopathic RLS versus controls (receiver operating characteristics) is 0.91, specificity is 0.90, and sensitivity is 0.82. TCS provides an interesting additional instrument in the diagnosis of RLS. Therefore, SN hypoechogenicity (SN sum area <0.2 cm(2)), which is supposed to indicate a decreased SN iron content, is a marker for RLS. Further studies are needed to investigate its significance for the pathophysiology of this frequent movement disorder and possible clinical applications.

AB - Pathological studies demonstrate a decreased iron content in the substantia nigra (SN) contributing to the pathophysiology of restless legs syndrome (RLS). SN echogenicity as measured by transcranial sonography (TCS) correlates with the SN iron content. The objective of this study was to determine a critical value to define SN hypoechogenicity as a potential marker for RLS. There were 49 RLS patients (39 idiopathic, 10 secondary) and 49 age- and sex-matched controls who underwent TCS by 2 independent and blinded examiners to determine the area of SN echogenicity. We found that SN echogenicity is significantly decreased in RLS patients compared to healthy controls (P <0.001). SN hypoechogenicity (sum area of SN echogenicity of both sides <0.2 cm(2)) is more common in idiopathic than in secondary RLS patients. The area under curve for idiopathic RLS versus controls (receiver operating characteristics) is 0.91, specificity is 0.90, and sensitivity is 0.82. TCS provides an interesting additional instrument in the diagnosis of RLS. Therefore, SN hypoechogenicity (SN sum area <0.2 cm(2)), which is supposed to indicate a decreased SN iron content, is a marker for RLS. Further studies are needed to investigate its significance for the pathophysiology of this frequent movement disorder and possible clinical applications.

M3 - SCORING: Journal article

VL - 22

SP - 187

EP - 192

JO - MOVEMENT DISORD

JF - MOVEMENT DISORD

SN - 0885-3185

IS - 2

M1 - 2

ER -