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Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study

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Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study. / Ivanov, Iliyan; Parvaz, Muhammad A; Velthorst, Eva; Shaik, Riaz B; Sandin, Sven; Gan, Gabriela; Spechler, Philip; Albaugh, Matthew D; Chaarani, Bader; Mackey, Scott; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Artiges, Eric; Lemaitre, Herve; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Hohmann, Sarah; Millenet, Sabina; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Garavan, Hugh; IMAGEN Consortium.

In: J AM ACAD CHILD PSY, Vol. 60, No. 5, 05.2021, p. 623-636.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ivanov, I, Parvaz, MA, Velthorst, E, Shaik, RB, Sandin, S, Gan, G, Spechler, P, Albaugh, MD, Chaarani, B, Mackey, S, Banaschewski, T, Bokde, ALW, Bromberg, U, Büchel, C, Quinlan, EB, Desrivières, S, Flor, H, Grigis, A, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Paillère Martinot, M-L, Artiges, E, Lemaitre, H, Nees, F, Orfanos, DP, Paus, T, Poustka, L, Hohmann, S, Millenet, S, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Schumann, G, Garavan, H & IMAGEN Consortium 2021, 'Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study', J AM ACAD CHILD PSY, vol. 60, no. 5, pp. 623-636. https://doi.org/10.1016/j.jaac.2020.08.443

APA

Ivanov, I., Parvaz, M. A., Velthorst, E., Shaik, R. B., Sandin, S., Gan, G., Spechler, P., Albaugh, M. D., Chaarani, B., Mackey, S., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E. B., Desrivières, S., Flor, H., Grigis, A., Gowland, P., ... IMAGEN Consortium (2021). Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study. J AM ACAD CHILD PSY, 60(5), 623-636. https://doi.org/10.1016/j.jaac.2020.08.443

Vancouver

Ivanov I, Parvaz MA, Velthorst E, Shaik RB, Sandin S, Gan G et al. Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study. J AM ACAD CHILD PSY. 2021 May;60(5):623-636. https://doi.org/10.1016/j.jaac.2020.08.443

Bibtex

@article{3e084e5f205e482a9f93fc4457d7a87b,
title = "Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study",
abstract = "OBJECTIVE: It is unclear whether deviations in brain and behavioral development, which may underpin elevated substance use during adolescence, are predispositions for or consequences of substance use initiation. Here, we examine behavioral and neuroimaging indices at early and mid-adolescence in drug-naive youths to identify possible predisposing factors for substance use initiation and its possible consequences.METHOD: Among 304 drug-naive adolescents at baseline (age 14 years) from the IMAGEN dataset, 83 stayed drug-naive, 133 used alcohol on 1 to 9 occasions, 42 on 10 to 19 occasions, 27 on 20 to 39 occasions, and 19 on >40 occasions at follow-up (age 16 years). Baseline measures included brain activation during the Monetary Incentive Delay task. Data at both baseline and follow-up included measures of trait impulsivity and delay discounting.RESULTS: From baseline to follow-up, impulsivity decreased in the 0 and 1- to 9-occasions groups (p < .004), did not change in the 10- to 19-occasions and 20- to 29-occasions groups (p > .294), and uncharacteristically increased in the >40-occasions group (p = .046). Furthermore, blunted medial orbitofrontal cortex activation during reward outcome at baseline significantly predicted higher alcohol use frequency at follow-up, above and beyond behavioral and clinical variables (p = .008).CONCLUSION: These results suggest that the transition from no use to frequent drinking in early to mid-adolescence may disrupt normative developmental changes in behavioral control. In addition, blunted activity of the medial orbitofrontal cortex during reward outcome may underscore a predisposition toward the development of more severe alcohol use in adolescents. This distinction is clinically important, as it informs early intervention efforts in preventing the onset of substance use disorder in adolescents.",
author = "Iliyan Ivanov and Parvaz, {Muhammad A} and Eva Velthorst and Shaik, {Riaz B} and Sven Sandin and Gabriela Gan and Philip Spechler and Albaugh, {Matthew D} and Bader Chaarani and Scott Mackey and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Quinlan, {Erin Burke} and Sylvane Desrivi{\`e}res and Herta Flor and Antoine Grigis and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and {Paill{\`e}re Martinot}, Marie-Laure and Eric Artiges and Herve Lemaitre and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Sarah Hohmann and Sabina Millenet and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Gunter Schumann and Hugh Garavan and {IMAGEN Consortium}",
note = "Copyright {\textcopyright} 2020 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.",
year = "2021",
month = may,
doi = "10.1016/j.jaac.2020.08.443",
language = "English",
volume = "60",
pages = "623--636",
journal = "J AM ACAD CHILD PSY",
issn = "0890-8567",
publisher = "Elsevier Limited",
number = "5",

}

RIS

TY - JOUR

T1 - Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study

AU - Ivanov, Iliyan

AU - Parvaz, Muhammad A

AU - Velthorst, Eva

AU - Shaik, Riaz B

AU - Sandin, Sven

AU - Gan, Gabriela

AU - Spechler, Philip

AU - Albaugh, Matthew D

AU - Chaarani, Bader

AU - Mackey, Scott

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Quinlan, Erin Burke

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Grigis, Antoine

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Paillère Martinot, Marie-Laure

AU - Artiges, Eric

AU - Lemaitre, Herve

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Hohmann, Sarah

AU - Millenet, Sabina

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Garavan, Hugh

AU - IMAGEN Consortium

N1 - Copyright © 2020 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2021/5

Y1 - 2021/5

N2 - OBJECTIVE: It is unclear whether deviations in brain and behavioral development, which may underpin elevated substance use during adolescence, are predispositions for or consequences of substance use initiation. Here, we examine behavioral and neuroimaging indices at early and mid-adolescence in drug-naive youths to identify possible predisposing factors for substance use initiation and its possible consequences.METHOD: Among 304 drug-naive adolescents at baseline (age 14 years) from the IMAGEN dataset, 83 stayed drug-naive, 133 used alcohol on 1 to 9 occasions, 42 on 10 to 19 occasions, 27 on 20 to 39 occasions, and 19 on >40 occasions at follow-up (age 16 years). Baseline measures included brain activation during the Monetary Incentive Delay task. Data at both baseline and follow-up included measures of trait impulsivity and delay discounting.RESULTS: From baseline to follow-up, impulsivity decreased in the 0 and 1- to 9-occasions groups (p < .004), did not change in the 10- to 19-occasions and 20- to 29-occasions groups (p > .294), and uncharacteristically increased in the >40-occasions group (p = .046). Furthermore, blunted medial orbitofrontal cortex activation during reward outcome at baseline significantly predicted higher alcohol use frequency at follow-up, above and beyond behavioral and clinical variables (p = .008).CONCLUSION: These results suggest that the transition from no use to frequent drinking in early to mid-adolescence may disrupt normative developmental changes in behavioral control. In addition, blunted activity of the medial orbitofrontal cortex during reward outcome may underscore a predisposition toward the development of more severe alcohol use in adolescents. This distinction is clinically important, as it informs early intervention efforts in preventing the onset of substance use disorder in adolescents.

AB - OBJECTIVE: It is unclear whether deviations in brain and behavioral development, which may underpin elevated substance use during adolescence, are predispositions for or consequences of substance use initiation. Here, we examine behavioral and neuroimaging indices at early and mid-adolescence in drug-naive youths to identify possible predisposing factors for substance use initiation and its possible consequences.METHOD: Among 304 drug-naive adolescents at baseline (age 14 years) from the IMAGEN dataset, 83 stayed drug-naive, 133 used alcohol on 1 to 9 occasions, 42 on 10 to 19 occasions, 27 on 20 to 39 occasions, and 19 on >40 occasions at follow-up (age 16 years). Baseline measures included brain activation during the Monetary Incentive Delay task. Data at both baseline and follow-up included measures of trait impulsivity and delay discounting.RESULTS: From baseline to follow-up, impulsivity decreased in the 0 and 1- to 9-occasions groups (p < .004), did not change in the 10- to 19-occasions and 20- to 29-occasions groups (p > .294), and uncharacteristically increased in the >40-occasions group (p = .046). Furthermore, blunted medial orbitofrontal cortex activation during reward outcome at baseline significantly predicted higher alcohol use frequency at follow-up, above and beyond behavioral and clinical variables (p = .008).CONCLUSION: These results suggest that the transition from no use to frequent drinking in early to mid-adolescence may disrupt normative developmental changes in behavioral control. In addition, blunted activity of the medial orbitofrontal cortex during reward outcome may underscore a predisposition toward the development of more severe alcohol use in adolescents. This distinction is clinically important, as it informs early intervention efforts in preventing the onset of substance use disorder in adolescents.

U2 - 10.1016/j.jaac.2020.08.443

DO - 10.1016/j.jaac.2020.08.443

M3 - SCORING: Journal article

C2 - 33011213

VL - 60

SP - 623

EP - 636

JO - J AM ACAD CHILD PSY

JF - J AM ACAD CHILD PSY

SN - 0890-8567

IS - 5

ER -