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Subsquamous extension of intestinal metaplasia is detected in 98% of cases of neoplastic Barrett's esophagus

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Subsquamous extension of intestinal metaplasia is detected in 98% of cases of neoplastic Barrett's esophagus. / Anders, Mario; Lucks, Yasmin; El-Masry, Muhammad Abbas; Quaas, Alexander; Rösch, Thomas; Schachschal, Guido; Bähr, Christina; Gauger, Ulrich; Sauter, Guido; Izbicki, Jakob R; Marx, Andreas H.

In: CLIN GASTROENTEROL H, Vol. 12, No. 3, 01.03.2014, p. 405-10.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Anders, M, Lucks, Y, El-Masry, MA, Quaas, A, Rösch, T, Schachschal, G, Bähr, C, Gauger, U, Sauter, G, Izbicki, JR & Marx, AH 2014, 'Subsquamous extension of intestinal metaplasia is detected in 98% of cases of neoplastic Barrett's esophagus', CLIN GASTROENTEROL H, vol. 12, no. 3, pp. 405-10. https://doi.org/10.1016/j.cgh.2013.07.013

APA

Anders, M., Lucks, Y., El-Masry, M. A., Quaas, A., Rösch, T., Schachschal, G., Bähr, C., Gauger, U., Sauter, G., Izbicki, J. R., & Marx, A. H. (2014). Subsquamous extension of intestinal metaplasia is detected in 98% of cases of neoplastic Barrett's esophagus. CLIN GASTROENTEROL H, 12(3), 405-10. https://doi.org/10.1016/j.cgh.2013.07.013

Vancouver

Anders M, Lucks Y, El-Masry MA, Quaas A, Rösch T, Schachschal G et al. Subsquamous extension of intestinal metaplasia is detected in 98% of cases of neoplastic Barrett's esophagus. CLIN GASTROENTEROL H. 2014 Mar 1;12(3):405-10. https://doi.org/10.1016/j.cgh.2013.07.013

Bibtex

@article{208bbe8837e64ffaa2402c8c67a60ba2,
title = "Subsquamous extension of intestinal metaplasia is detected in 98% of cases of neoplastic Barrett's esophagus",
abstract = "BACKGROUND & AIMS: Subsquamous intestinal metaplasia (SSIM) has been observed after endotherapy in patients with neoplastic Barrett's esophagus (BE). However, it is not clear whether SSIM occurs in untreated patients. Incompletely eradicated SSIM could provide a source of recurrent disease. We assessed its prevalence in a large cohort of patients who had not received endoscopic therapy.METHODS: Two experienced pathologists analyzed 138 samples of 506 resection specimens found to contain squamous epithelium from 110 patients with neoplastic BE treated by widespread endoscopic mucosal resection (92 men; mean age, 66 years). The maximum extent of SSIM was measured.RESULTS: Of the 138 samples analyzed, 124 (89.9%) were found to contain SSIM from 108 of the 110 patients (98.2%). The mean length of SSIM was 3.3 mm (range, 0.2-9.6 mm; 25% ≥ 5 mm); SSIM length correlated with BE length (P < .05). In 83 of 138 samples (60.1%), the SSIM consisted partially or entirely of neoplasias of different grades, with a mean subsquamous extension of 3.3 mm; the extension correlated with grade of neoplasia (P = .0001).CONCLUSIONS: Most patients with BE with neoplasia (of all grades) have subsquamous extension of intestinal metaplasia, including subsquamous extension of lesions at the squamocolumnar junction. Therefore, biopsy and resection of neoplastic BE should extend at least 1 cm into the squamous epithelium.",
author = "Mario Anders and Yasmin Lucks and El-Masry, {Muhammad Abbas} and Alexander Quaas and Thomas R{\"o}sch and Guido Schachschal and Christina B{\"a}hr and Ulrich Gauger and Guido Sauter and Izbicki, {Jakob R} and Marx, {Andreas H}",
note = "Copyright {\textcopyright} 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.",
year = "2014",
month = mar,
day = "1",
doi = "10.1016/j.cgh.2013.07.013",
language = "English",
volume = "12",
pages = "405--10",
journal = "CLIN GASTROENTEROL H",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Subsquamous extension of intestinal metaplasia is detected in 98% of cases of neoplastic Barrett's esophagus

AU - Anders, Mario

AU - Lucks, Yasmin

AU - El-Masry, Muhammad Abbas

AU - Quaas, Alexander

AU - Rösch, Thomas

AU - Schachschal, Guido

AU - Bähr, Christina

AU - Gauger, Ulrich

AU - Sauter, Guido

AU - Izbicki, Jakob R

AU - Marx, Andreas H

N1 - Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - BACKGROUND & AIMS: Subsquamous intestinal metaplasia (SSIM) has been observed after endotherapy in patients with neoplastic Barrett's esophagus (BE). However, it is not clear whether SSIM occurs in untreated patients. Incompletely eradicated SSIM could provide a source of recurrent disease. We assessed its prevalence in a large cohort of patients who had not received endoscopic therapy.METHODS: Two experienced pathologists analyzed 138 samples of 506 resection specimens found to contain squamous epithelium from 110 patients with neoplastic BE treated by widespread endoscopic mucosal resection (92 men; mean age, 66 years). The maximum extent of SSIM was measured.RESULTS: Of the 138 samples analyzed, 124 (89.9%) were found to contain SSIM from 108 of the 110 patients (98.2%). The mean length of SSIM was 3.3 mm (range, 0.2-9.6 mm; 25% ≥ 5 mm); SSIM length correlated with BE length (P < .05). In 83 of 138 samples (60.1%), the SSIM consisted partially or entirely of neoplasias of different grades, with a mean subsquamous extension of 3.3 mm; the extension correlated with grade of neoplasia (P = .0001).CONCLUSIONS: Most patients with BE with neoplasia (of all grades) have subsquamous extension of intestinal metaplasia, including subsquamous extension of lesions at the squamocolumnar junction. Therefore, biopsy and resection of neoplastic BE should extend at least 1 cm into the squamous epithelium.

AB - BACKGROUND & AIMS: Subsquamous intestinal metaplasia (SSIM) has been observed after endotherapy in patients with neoplastic Barrett's esophagus (BE). However, it is not clear whether SSIM occurs in untreated patients. Incompletely eradicated SSIM could provide a source of recurrent disease. We assessed its prevalence in a large cohort of patients who had not received endoscopic therapy.METHODS: Two experienced pathologists analyzed 138 samples of 506 resection specimens found to contain squamous epithelium from 110 patients with neoplastic BE treated by widespread endoscopic mucosal resection (92 men; mean age, 66 years). The maximum extent of SSIM was measured.RESULTS: Of the 138 samples analyzed, 124 (89.9%) were found to contain SSIM from 108 of the 110 patients (98.2%). The mean length of SSIM was 3.3 mm (range, 0.2-9.6 mm; 25% ≥ 5 mm); SSIM length correlated with BE length (P < .05). In 83 of 138 samples (60.1%), the SSIM consisted partially or entirely of neoplasias of different grades, with a mean subsquamous extension of 3.3 mm; the extension correlated with grade of neoplasia (P = .0001).CONCLUSIONS: Most patients with BE with neoplasia (of all grades) have subsquamous extension of intestinal metaplasia, including subsquamous extension of lesions at the squamocolumnar junction. Therefore, biopsy and resection of neoplastic BE should extend at least 1 cm into the squamous epithelium.

U2 - 10.1016/j.cgh.2013.07.013

DO - 10.1016/j.cgh.2013.07.013

M3 - SCORING: Journal article

C2 - 23891922

VL - 12

SP - 405

EP - 410

JO - CLIN GASTROENTEROL H

JF - CLIN GASTROENTEROL H

SN - 1542-3565

IS - 3

ER -