Subregions of the ventral striatum show preferential coding of reward magnitude and probability
Standard
Subregions of the ventral striatum show preferential coding of reward magnitude and probability. / Yacubian, Juliana; Sommer-Blöchl, Tobias; Schroeder, Katrin; Gläscher, Jan; Braus, Dieter F; Büchel, Christian.
In: NEUROIMAGE, Vol. 38, No. 3, 15.11.2007, p. 557-63.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Subregions of the ventral striatum show preferential coding of reward magnitude and probability
AU - Yacubian, Juliana
AU - Sommer-Blöchl, Tobias
AU - Schroeder, Katrin
AU - Gläscher, Jan
AU - Braus, Dieter F
AU - Büchel, Christian
PY - 2007/11/15
Y1 - 2007/11/15
N2 - As shown in non-human primate and human fMRI studies the probability and magnitude of anticipated rewards modulate activity in the mesolimbic dopaminergic system. Importantly, non-human primate data have revealed that single dopaminergic neurons code for both probability and magnitude of expected reward, suggesting an identical system. Using a guessing task that allowed the independent assessment of the factors probability and magnitude we were able to assess the impact of reward probability and magnitude in ventral striatal subregions in a large sample (n=98). We observed more anterior and lateral peak activation foci in the ventral striatum for reward probability and a more posterior and medial activation peak for reward magnitude, suggesting a functional segregation at the mesoscopic level. Importantly, this functional bias observed for the group average was also tested in each individual subject, allowing for proper random effects inference for the spatial dissociation. Taken together, our data point toward a functional dissociation of neuronal assemblies suggesting that certain populations of neurons are more sensitive to expected reward probability and other populations are more sensitive to reward magnitude.
AB - As shown in non-human primate and human fMRI studies the probability and magnitude of anticipated rewards modulate activity in the mesolimbic dopaminergic system. Importantly, non-human primate data have revealed that single dopaminergic neurons code for both probability and magnitude of expected reward, suggesting an identical system. Using a guessing task that allowed the independent assessment of the factors probability and magnitude we were able to assess the impact of reward probability and magnitude in ventral striatal subregions in a large sample (n=98). We observed more anterior and lateral peak activation foci in the ventral striatum for reward probability and a more posterior and medial activation peak for reward magnitude, suggesting a functional segregation at the mesoscopic level. Importantly, this functional bias observed for the group average was also tested in each individual subject, allowing for proper random effects inference for the spatial dissociation. Taken together, our data point toward a functional dissociation of neuronal assemblies suggesting that certain populations of neurons are more sensitive to expected reward probability and other populations are more sensitive to reward magnitude.
KW - Brain Mapping
KW - Corpus Striatum
KW - Functional Laterality
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Magnetic Resonance Imaging
KW - Play and Playthings
KW - Probability
KW - Reward
KW - Space Perception
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.neuroimage.2007.08.007
DO - 10.1016/j.neuroimage.2007.08.007
M3 - SCORING: Journal article
C2 - 17889562
VL - 38
SP - 557
EP - 563
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
IS - 3
ER -