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Subjective Cognitive Decline May Be a Stronger Predictor of Incident Dementia in Women than in Men

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Subjective Cognitive Decline May Be a Stronger Predictor of Incident Dementia in Women than in Men. / Heser, Kathrin; Kleineidam, Luca; Wiese, Birgitt; Oey, Anke; Roehr, Susanne; Pabst, Alexander; Kaduszkiewicz, Hanna; van den Bussche, Hendrik; Brettschneider, Christian; König, Hans-Helmut; Weyerer, Siegfried; Werle, Jochen; Fuchs, Angela; Pentzek, Michael; Mösch, Edelgard; Bickel, Horst; Maier, Wolfgang; Scherer, Martin; Riedel-Heller, Steffi G; Wagner, Michael.

In: J ALZHEIMERS DIS, Vol. 68, No. 4, 23.04.2019, p. 1469-1478.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heser, K, Kleineidam, L, Wiese, B, Oey, A, Roehr, S, Pabst, A, Kaduszkiewicz, H, van den Bussche, H, Brettschneider, C, König, H-H, Weyerer, S, Werle, J, Fuchs, A, Pentzek, M, Mösch, E, Bickel, H, Maier, W, Scherer, M, Riedel-Heller, SG & Wagner, M 2019, 'Subjective Cognitive Decline May Be a Stronger Predictor of Incident Dementia in Women than in Men', J ALZHEIMERS DIS, vol. 68, no. 4, pp. 1469-1478. https://doi.org/10.3233/JAD-180981

APA

Heser, K., Kleineidam, L., Wiese, B., Oey, A., Roehr, S., Pabst, A., Kaduszkiewicz, H., van den Bussche, H., Brettschneider, C., König, H-H., Weyerer, S., Werle, J., Fuchs, A., Pentzek, M., Mösch, E., Bickel, H., Maier, W., Scherer, M., Riedel-Heller, S. G., & Wagner, M. (2019). Subjective Cognitive Decline May Be a Stronger Predictor of Incident Dementia in Women than in Men. J ALZHEIMERS DIS, 68(4), 1469-1478. https://doi.org/10.3233/JAD-180981

Vancouver

Heser K, Kleineidam L, Wiese B, Oey A, Roehr S, Pabst A et al. Subjective Cognitive Decline May Be a Stronger Predictor of Incident Dementia in Women than in Men. J ALZHEIMERS DIS. 2019 Apr 23;68(4):1469-1478. https://doi.org/10.3233/JAD-180981

Bibtex

@article{a0a9017fd9ec459f8ae6701996ced3bc,
title = "Subjective Cognitive Decline May Be a Stronger Predictor of Incident Dementia in Women than in Men",
abstract = "BACKGROUND/OBJECTIVE: Subjective cognitive decline (SCD) has often been associated with an increased risk for subsequent dementia. However, sex-specific associations are understudied until now.METHODS: Cross-sectional and longitudinal associations over a follow-up period of up to 13 years were investigated in a sample of participants without objective cognitive impairment at baseline (n = 2,422, mean age = 79.63 years). Logistic regression and Cox proportional hazards models were conducted.RESULTS: Women less frequently reported SCD without worries (p <  0.001), but tended to report more often SCD with worries (p = 0.082) at baseline compared to men. In models adjusted for age, education, cognitive status, and depressive symptoms, SCD at baseline increased the risk for subsequent dementia (p <  0.001), and this effect was less pronounced in males (interaction sex×SCD: p = 0.022). Stratified analyses showed that SCD increased the risk for subsequent dementia in women (HR = 1.77, p <  0.001), but not in men (HR = 1.07, p = 0.682). Similar results were found in analyses with SCD without and with worries, except that SCD with worries also predicted subsequent Alzheimer's disease (AD) in men (p = 0.037).CONCLUSION: At baseline, men reported more SCD without worries and women tended to report more SCD with worries. SCD in women was more strongly associated with subsequent dementia. SCD without and with worries was related to incident dementia and AD in women, whereas in men only SCD with worries increased the risk for AD, but not for all-cause dementia.",
keywords = "Journal Article",
author = "Kathrin Heser and Luca Kleineidam and Birgitt Wiese and Anke Oey and Susanne Roehr and Alexander Pabst and Hanna Kaduszkiewicz and {van den Bussche}, Hendrik and Christian Brettschneider and Hans-Helmut K{\"o}nig and Siegfried Weyerer and Jochen Werle and Angela Fuchs and Michael Pentzek and Edelgard M{\"o}sch and Horst Bickel and Wolfgang Maier and Martin Scherer and Riedel-Heller, {Steffi G} and Michael Wagner",
year = "2019",
month = apr,
day = "23",
doi = "10.3233/JAD-180981",
language = "English",
volume = "68",
pages = "1469--1478",
journal = "J ALZHEIMERS DIS",
issn = "1387-2877",
publisher = "IOS Press",
number = "4",

}

RIS

TY - JOUR

T1 - Subjective Cognitive Decline May Be a Stronger Predictor of Incident Dementia in Women than in Men

AU - Heser, Kathrin

AU - Kleineidam, Luca

AU - Wiese, Birgitt

AU - Oey, Anke

AU - Roehr, Susanne

AU - Pabst, Alexander

AU - Kaduszkiewicz, Hanna

AU - van den Bussche, Hendrik

AU - Brettschneider, Christian

AU - König, Hans-Helmut

AU - Weyerer, Siegfried

AU - Werle, Jochen

AU - Fuchs, Angela

AU - Pentzek, Michael

AU - Mösch, Edelgard

AU - Bickel, Horst

AU - Maier, Wolfgang

AU - Scherer, Martin

AU - Riedel-Heller, Steffi G

AU - Wagner, Michael

PY - 2019/4/23

Y1 - 2019/4/23

N2 - BACKGROUND/OBJECTIVE: Subjective cognitive decline (SCD) has often been associated with an increased risk for subsequent dementia. However, sex-specific associations are understudied until now.METHODS: Cross-sectional and longitudinal associations over a follow-up period of up to 13 years were investigated in a sample of participants without objective cognitive impairment at baseline (n = 2,422, mean age = 79.63 years). Logistic regression and Cox proportional hazards models were conducted.RESULTS: Women less frequently reported SCD without worries (p <  0.001), but tended to report more often SCD with worries (p = 0.082) at baseline compared to men. In models adjusted for age, education, cognitive status, and depressive symptoms, SCD at baseline increased the risk for subsequent dementia (p <  0.001), and this effect was less pronounced in males (interaction sex×SCD: p = 0.022). Stratified analyses showed that SCD increased the risk for subsequent dementia in women (HR = 1.77, p <  0.001), but not in men (HR = 1.07, p = 0.682). Similar results were found in analyses with SCD without and with worries, except that SCD with worries also predicted subsequent Alzheimer's disease (AD) in men (p = 0.037).CONCLUSION: At baseline, men reported more SCD without worries and women tended to report more SCD with worries. SCD in women was more strongly associated with subsequent dementia. SCD without and with worries was related to incident dementia and AD in women, whereas in men only SCD with worries increased the risk for AD, but not for all-cause dementia.

AB - BACKGROUND/OBJECTIVE: Subjective cognitive decline (SCD) has often been associated with an increased risk for subsequent dementia. However, sex-specific associations are understudied until now.METHODS: Cross-sectional and longitudinal associations over a follow-up period of up to 13 years were investigated in a sample of participants without objective cognitive impairment at baseline (n = 2,422, mean age = 79.63 years). Logistic regression and Cox proportional hazards models were conducted.RESULTS: Women less frequently reported SCD without worries (p <  0.001), but tended to report more often SCD with worries (p = 0.082) at baseline compared to men. In models adjusted for age, education, cognitive status, and depressive symptoms, SCD at baseline increased the risk for subsequent dementia (p <  0.001), and this effect was less pronounced in males (interaction sex×SCD: p = 0.022). Stratified analyses showed that SCD increased the risk for subsequent dementia in women (HR = 1.77, p <  0.001), but not in men (HR = 1.07, p = 0.682). Similar results were found in analyses with SCD without and with worries, except that SCD with worries also predicted subsequent Alzheimer's disease (AD) in men (p = 0.037).CONCLUSION: At baseline, men reported more SCD without worries and women tended to report more SCD with worries. SCD in women was more strongly associated with subsequent dementia. SCD without and with worries was related to incident dementia and AD in women, whereas in men only SCD with worries increased the risk for AD, but not for all-cause dementia.

KW - Journal Article

U2 - 10.3233/JAD-180981

DO - 10.3233/JAD-180981

M3 - SCORING: Journal article

C2 - 30909220

VL - 68

SP - 1469

EP - 1478

JO - J ALZHEIMERS DIS

JF - J ALZHEIMERS DIS

SN - 1387-2877

IS - 4

ER -