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Subjective cognitive decline is longitudinally associated with lower health-related quality of life

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Subjective cognitive decline is longitudinally associated with lower health-related quality of life. / Roehr, Susanne; Luck, Tobias; Pabst, Alexander; Bickel, Horst; König, Hans-Helmut; Lühmann, Dagmar; Fuchs, Angela; Wolfsgruber, Steffen; Wiese, Birgitt; Weyerer, Siegfried; Mösch, Edelgard; Brettschneider, Christian; Mallon, Tina; Pentzek, Michael; Wagner, Michael; Mamone, Silke; Werle, Jochen; Scherer, Martin; Maier, Wolfgang; Jessen, Frank; Riedel-Heller, Steffi G; AgeCoDe Study Group.

In: INT PSYCHOGERIATR, Vol. 29, No. 12, 12.2017, p. 1939-1950.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Roehr, S, Luck, T, Pabst, A, Bickel, H, König, H-H, Lühmann, D, Fuchs, A, Wolfsgruber, S, Wiese, B, Weyerer, S, Mösch, E, Brettschneider, C, Mallon, T, Pentzek, M, Wagner, M, Mamone, S, Werle, J, Scherer, M, Maier, W, Jessen, F, Riedel-Heller, SG & AgeCoDe Study Group 2017, 'Subjective cognitive decline is longitudinally associated with lower health-related quality of life', INT PSYCHOGERIATR, vol. 29, no. 12, pp. 1939-1950. https://doi.org/10.1017/S1041610217001399

APA

Roehr, S., Luck, T., Pabst, A., Bickel, H., König, H-H., Lühmann, D., Fuchs, A., Wolfsgruber, S., Wiese, B., Weyerer, S., Mösch, E., Brettschneider, C., Mallon, T., Pentzek, M., Wagner, M., Mamone, S., Werle, J., Scherer, M., Maier, W., ... AgeCoDe Study Group (2017). Subjective cognitive decline is longitudinally associated with lower health-related quality of life. INT PSYCHOGERIATR, 29(12), 1939-1950. https://doi.org/10.1017/S1041610217001399

Vancouver

Roehr S, Luck T, Pabst A, Bickel H, König H-H, Lühmann D et al. Subjective cognitive decline is longitudinally associated with lower health-related quality of life. INT PSYCHOGERIATR. 2017 Dec;29(12):1939-1950. https://doi.org/10.1017/S1041610217001399

Bibtex

@article{3196e29783e04ceb87d6041b3c9e2220,
title = "Subjective cognitive decline is longitudinally associated with lower health-related quality of life",
abstract = "BACKGROUND: Subjective cognitive decline (SCD), the potentially earliest notable manifestation of preclinical Alzheimer's disease and other dementias, was consistently associated with lower quality of life in cross-sectional studies. The aim of this study was to investigate whether such an association persists longitudinally - particularly with health-related quality of life (HRQoL) in older individuals without cognitive impairment.METHODS: Data were derived from follow-up 2-6 of the prospective Germany Study on Ageing, Cognition and Dementia in Primary Care (AgeCoDe) covering a total six-year observation period. We used linear mixed effects models to estimate the effect of SCD on HRQoL measured by the EQ-5D visual analogue scale (EQ VAS).RESULTS: Of 1,387 cognitively unimpaired individuals aged 82.2 years (SD = 3.2) on average, 702 (50.6%) reported SCD and 230 (16.6%) with SCD-related concerns. Effect estimates of the linear mixed effects models revealed lower HRQoL in individuals with SCD (unadjusted: -3.7 points on the EQ VAS, 95%CI = -5.3 to -2.1; SE = 0.8; p < 0.001; adjusted: -2.9 points, 95%CI = -3.9 to -1.9; SE = 0.5; p < 0.001) than in individuals without SCD. The effect was most pronounced in SCD with related concerns (unadjusted: -5.4, 95%CI = -7.6 to -3.2; SE = 1.1; p < 0.001; adjusted: -4.3, 95%CI = -5.8 to -2.9, SE = 0.7; p < 0.001).CONCLUSION: SCD constitutes a serious issue to older cognitively unimpaired individuals that is depicted in persisting lower levels of HRQoL beyond depressive symptoms and functional impairment. Therefore, SCD should be taken seriously in clinical practice.",
keywords = "Journal Article",
author = "Susanne Roehr and Tobias Luck and Alexander Pabst and Horst Bickel and Hans-Helmut K{\"o}nig and Dagmar L{\"u}hmann and Angela Fuchs and Steffen Wolfsgruber and Birgitt Wiese and Siegfried Weyerer and Edelgard M{\"o}sch and Christian Brettschneider and Tina Mallon and Michael Pentzek and Michael Wagner and Silke Mamone and Jochen Werle and Martin Scherer and Wolfgang Maier and Frank Jessen and Riedel-Heller, {Steffi G} and {AgeCoDe Study Group}",
year = "2017",
month = dec,
doi = "10.1017/S1041610217001399",
language = "English",
volume = "29",
pages = "1939--1950",
journal = "INT PSYCHOGERIATR",
issn = "1041-6102",
publisher = "Cambridge University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Subjective cognitive decline is longitudinally associated with lower health-related quality of life

AU - Roehr, Susanne

AU - Luck, Tobias

AU - Pabst, Alexander

AU - Bickel, Horst

AU - König, Hans-Helmut

AU - Lühmann, Dagmar

AU - Fuchs, Angela

AU - Wolfsgruber, Steffen

AU - Wiese, Birgitt

AU - Weyerer, Siegfried

AU - Mösch, Edelgard

AU - Brettschneider, Christian

AU - Mallon, Tina

AU - Pentzek, Michael

AU - Wagner, Michael

AU - Mamone, Silke

AU - Werle, Jochen

AU - Scherer, Martin

AU - Maier, Wolfgang

AU - Jessen, Frank

AU - Riedel-Heller, Steffi G

AU - AgeCoDe Study Group

PY - 2017/12

Y1 - 2017/12

N2 - BACKGROUND: Subjective cognitive decline (SCD), the potentially earliest notable manifestation of preclinical Alzheimer's disease and other dementias, was consistently associated with lower quality of life in cross-sectional studies. The aim of this study was to investigate whether such an association persists longitudinally - particularly with health-related quality of life (HRQoL) in older individuals without cognitive impairment.METHODS: Data were derived from follow-up 2-6 of the prospective Germany Study on Ageing, Cognition and Dementia in Primary Care (AgeCoDe) covering a total six-year observation period. We used linear mixed effects models to estimate the effect of SCD on HRQoL measured by the EQ-5D visual analogue scale (EQ VAS).RESULTS: Of 1,387 cognitively unimpaired individuals aged 82.2 years (SD = 3.2) on average, 702 (50.6%) reported SCD and 230 (16.6%) with SCD-related concerns. Effect estimates of the linear mixed effects models revealed lower HRQoL in individuals with SCD (unadjusted: -3.7 points on the EQ VAS, 95%CI = -5.3 to -2.1; SE = 0.8; p < 0.001; adjusted: -2.9 points, 95%CI = -3.9 to -1.9; SE = 0.5; p < 0.001) than in individuals without SCD. The effect was most pronounced in SCD with related concerns (unadjusted: -5.4, 95%CI = -7.6 to -3.2; SE = 1.1; p < 0.001; adjusted: -4.3, 95%CI = -5.8 to -2.9, SE = 0.7; p < 0.001).CONCLUSION: SCD constitutes a serious issue to older cognitively unimpaired individuals that is depicted in persisting lower levels of HRQoL beyond depressive symptoms and functional impairment. Therefore, SCD should be taken seriously in clinical practice.

AB - BACKGROUND: Subjective cognitive decline (SCD), the potentially earliest notable manifestation of preclinical Alzheimer's disease and other dementias, was consistently associated with lower quality of life in cross-sectional studies. The aim of this study was to investigate whether such an association persists longitudinally - particularly with health-related quality of life (HRQoL) in older individuals without cognitive impairment.METHODS: Data were derived from follow-up 2-6 of the prospective Germany Study on Ageing, Cognition and Dementia in Primary Care (AgeCoDe) covering a total six-year observation period. We used linear mixed effects models to estimate the effect of SCD on HRQoL measured by the EQ-5D visual analogue scale (EQ VAS).RESULTS: Of 1,387 cognitively unimpaired individuals aged 82.2 years (SD = 3.2) on average, 702 (50.6%) reported SCD and 230 (16.6%) with SCD-related concerns. Effect estimates of the linear mixed effects models revealed lower HRQoL in individuals with SCD (unadjusted: -3.7 points on the EQ VAS, 95%CI = -5.3 to -2.1; SE = 0.8; p < 0.001; adjusted: -2.9 points, 95%CI = -3.9 to -1.9; SE = 0.5; p < 0.001) than in individuals without SCD. The effect was most pronounced in SCD with related concerns (unadjusted: -5.4, 95%CI = -7.6 to -3.2; SE = 1.1; p < 0.001; adjusted: -4.3, 95%CI = -5.8 to -2.9, SE = 0.7; p < 0.001).CONCLUSION: SCD constitutes a serious issue to older cognitively unimpaired individuals that is depicted in persisting lower levels of HRQoL beyond depressive symptoms and functional impairment. Therefore, SCD should be taken seriously in clinical practice.

KW - Journal Article

U2 - 10.1017/S1041610217001399

DO - 10.1017/S1041610217001399

M3 - SCORING: Journal article

C2 - 28737118

VL - 29

SP - 1939

EP - 1950

JO - INT PSYCHOGERIATR

JF - INT PSYCHOGERIATR

SN - 1041-6102

IS - 12

ER -