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Subclinical impairment of lung function is related to mild cardiac dysfunction and manifest heart failure in the general population

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Subclinical impairment of lung function is related to mild cardiac dysfunction and manifest heart failure in the general population. / Baum, Christina; Ojeda, Francisco M; Wild, Philipp S; Rzayeva, Nargiz; Zeller, Tanja; Sinning, Christoph R; Pfeiffer, Norbert; Beutel, Manfred; Blettner, Maria; Lackner, Karl J; Blankenberg, Stefan; Münzel, Thomas; Rabe, Klaus F; Schnabel, Renate B; Gutenberg Health Study investigators.

In: INT J CARDIOL, Vol. 218, 01.09.2016, p. 298-304.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Baum, C, Ojeda, FM, Wild, PS, Rzayeva, N, Zeller, T, Sinning, CR, Pfeiffer, N, Beutel, M, Blettner, M, Lackner, KJ, Blankenberg, S, Münzel, T, Rabe, KF, Schnabel, RB & Gutenberg Health Study investigators 2016, 'Subclinical impairment of lung function is related to mild cardiac dysfunction and manifest heart failure in the general population', INT J CARDIOL, vol. 218, pp. 298-304. https://doi.org/10.1016/j.ijcard.2016.05.034

APA

Baum, C., Ojeda, F. M., Wild, P. S., Rzayeva, N., Zeller, T., Sinning, C. R., Pfeiffer, N., Beutel, M., Blettner, M., Lackner, K. J., Blankenberg, S., Münzel, T., Rabe, K. F., Schnabel, R. B., & Gutenberg Health Study investigators (2016). Subclinical impairment of lung function is related to mild cardiac dysfunction and manifest heart failure in the general population. INT J CARDIOL, 218, 298-304. https://doi.org/10.1016/j.ijcard.2016.05.034

Vancouver

Baum C, Ojeda FM, Wild PS, Rzayeva N, Zeller T, Sinning CR et al. Subclinical impairment of lung function is related to mild cardiac dysfunction and manifest heart failure in the general population. INT J CARDIOL. 2016 Sep 1;218:298-304. https://doi.org/10.1016/j.ijcard.2016.05.034

Bibtex

@article{c20ac81c0beb4cada2ef5d30791e12cf,
title = "Subclinical impairment of lung function is related to mild cardiac dysfunction and manifest heart failure in the general population",
abstract = "BACKGROUND: Lung function impairment has previously been related to heart failure, although no overt cardiovascular or structural heart disease is present. The extent to which pulmonary function is related to subclinical left ventricular impairment in the general population remains to be investigated.METHODS: 15010 individuals from the general population (mean age 55±11years, 50.5% men) in the Gutenberg Health Study underwent spirometry, transthoracic echocardiography and biomarker measurement. Forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) in percent of the predicted value and FEV1/FVC ratio were associated with echocardiographic measures of cardiac structure, systolic and diastolic function, biomarkers of cardiac necrosis (high-sensitive troponin I, hsTnI) and stress (N-terminal pro-B-type natriuretic peptide, Nt-proBNP) and heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF).RESULTS: Percent predicted FEV1 and FVC were significantly associated with hsTnI (P<0.001) and Nt-proBNP (P<0.001). Additionally, FEV1/FVC ratio was significantly related to hsTnI (P=0.0043) and Nt-proBNP (P<0.001). In the multivariable-adjusted linear regression analyses strongest associations were observed for percent predicted FEV1 and FVC with LVESD, E/e', SV and EF. FEV1/FVC ratio was significantly related with SV and EF. The three lung function parameters were significantly (P<0.001) associated with HFpEF and HFrEF. Associations remained statistically significant after exclusion of individuals with COPD.CONCLUSIONS: FEV1, FVC and FEV1/FVC ratio were associated with systolic and diastolic function and manifest heart failure. Our observations could show, that subclinical lung function impairment is related to a measurable reduction of left ventricular filling and cardiac output in the general population.",
keywords = "Adult, Aged, Female, Forced Expiratory Volume, Heart Failure/physiopathology, Heart Ventricles/physiopathology, Humans, Lung/physiopathology, Male, Middle Aged, Prospective Studies, Risk Factors, Stroke Volume",
author = "Christina Baum and Ojeda, {Francisco M} and Wild, {Philipp S} and Nargiz Rzayeva and Tanja Zeller and Sinning, {Christoph R} and Norbert Pfeiffer and Manfred Beutel and Maria Blettner and Lackner, {Karl J} and Stefan Blankenberg and Thomas M{\"u}nzel and Rabe, {Klaus F} and Schnabel, {Renate B} and {Gutenberg Health Study investigators}",
note = "Copyright {\textcopyright} 2016 Elsevier Ireland Ltd. All rights reserved.",
year = "2016",
month = sep,
day = "1",
doi = "10.1016/j.ijcard.2016.05.034",
language = "English",
volume = "218",
pages = "298--304",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Subclinical impairment of lung function is related to mild cardiac dysfunction and manifest heart failure in the general population

AU - Baum, Christina

AU - Ojeda, Francisco M

AU - Wild, Philipp S

AU - Rzayeva, Nargiz

AU - Zeller, Tanja

AU - Sinning, Christoph R

AU - Pfeiffer, Norbert

AU - Beutel, Manfred

AU - Blettner, Maria

AU - Lackner, Karl J

AU - Blankenberg, Stefan

AU - Münzel, Thomas

AU - Rabe, Klaus F

AU - Schnabel, Renate B

AU - Gutenberg Health Study investigators

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - BACKGROUND: Lung function impairment has previously been related to heart failure, although no overt cardiovascular or structural heart disease is present. The extent to which pulmonary function is related to subclinical left ventricular impairment in the general population remains to be investigated.METHODS: 15010 individuals from the general population (mean age 55±11years, 50.5% men) in the Gutenberg Health Study underwent spirometry, transthoracic echocardiography and biomarker measurement. Forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) in percent of the predicted value and FEV1/FVC ratio were associated with echocardiographic measures of cardiac structure, systolic and diastolic function, biomarkers of cardiac necrosis (high-sensitive troponin I, hsTnI) and stress (N-terminal pro-B-type natriuretic peptide, Nt-proBNP) and heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF).RESULTS: Percent predicted FEV1 and FVC were significantly associated with hsTnI (P<0.001) and Nt-proBNP (P<0.001). Additionally, FEV1/FVC ratio was significantly related to hsTnI (P=0.0043) and Nt-proBNP (P<0.001). In the multivariable-adjusted linear regression analyses strongest associations were observed for percent predicted FEV1 and FVC with LVESD, E/e', SV and EF. FEV1/FVC ratio was significantly related with SV and EF. The three lung function parameters were significantly (P<0.001) associated with HFpEF and HFrEF. Associations remained statistically significant after exclusion of individuals with COPD.CONCLUSIONS: FEV1, FVC and FEV1/FVC ratio were associated with systolic and diastolic function and manifest heart failure. Our observations could show, that subclinical lung function impairment is related to a measurable reduction of left ventricular filling and cardiac output in the general population.

AB - BACKGROUND: Lung function impairment has previously been related to heart failure, although no overt cardiovascular or structural heart disease is present. The extent to which pulmonary function is related to subclinical left ventricular impairment in the general population remains to be investigated.METHODS: 15010 individuals from the general population (mean age 55±11years, 50.5% men) in the Gutenberg Health Study underwent spirometry, transthoracic echocardiography and biomarker measurement. Forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) in percent of the predicted value and FEV1/FVC ratio were associated with echocardiographic measures of cardiac structure, systolic and diastolic function, biomarkers of cardiac necrosis (high-sensitive troponin I, hsTnI) and stress (N-terminal pro-B-type natriuretic peptide, Nt-proBNP) and heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF).RESULTS: Percent predicted FEV1 and FVC were significantly associated with hsTnI (P<0.001) and Nt-proBNP (P<0.001). Additionally, FEV1/FVC ratio was significantly related to hsTnI (P=0.0043) and Nt-proBNP (P<0.001). In the multivariable-adjusted linear regression analyses strongest associations were observed for percent predicted FEV1 and FVC with LVESD, E/e', SV and EF. FEV1/FVC ratio was significantly related with SV and EF. The three lung function parameters were significantly (P<0.001) associated with HFpEF and HFrEF. Associations remained statistically significant after exclusion of individuals with COPD.CONCLUSIONS: FEV1, FVC and FEV1/FVC ratio were associated with systolic and diastolic function and manifest heart failure. Our observations could show, that subclinical lung function impairment is related to a measurable reduction of left ventricular filling and cardiac output in the general population.

KW - Adult

KW - Aged

KW - Female

KW - Forced Expiratory Volume

KW - Heart Failure/physiopathology

KW - Heart Ventricles/physiopathology

KW - Humans

KW - Lung/physiopathology

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Risk Factors

KW - Stroke Volume

U2 - 10.1016/j.ijcard.2016.05.034

DO - 10.1016/j.ijcard.2016.05.034

M3 - SCORING: Journal article

C2 - 27240155

VL - 218

SP - 298

EP - 304

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -