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Subclinical coronary atherosclerosis and resting ECG abnormalities in an unselected general population

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Subclinical coronary atherosclerosis and resting ECG abnormalities in an unselected general population. / Möhlenkamp, Stefan; Schmermund, Axel; Lehmann, Nils; Roggenbuck, Ulla; Dragano, Nico; Stang, Andreas; Moebus, Susanne; Beck, Eva-Maria; Schlüter, Christamaria; Sack, Stefan; Meinertz, Thomas; Taylor, Allen; Jöckel, Karl-Heinz; Erbel, Raimund; Heinz Nixdorf Recall Study Investigators.

In: ATHEROSCLEROSIS, Vol. 196, No. 2, 02.2008, p. 786-794.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Möhlenkamp, S, Schmermund, A, Lehmann, N, Roggenbuck, U, Dragano, N, Stang, A, Moebus, S, Beck, E-M, Schlüter, C, Sack, S, Meinertz, T, Taylor, A, Jöckel, K-H, Erbel, R & Heinz Nixdorf Recall Study Investigators 2008, 'Subclinical coronary atherosclerosis and resting ECG abnormalities in an unselected general population', ATHEROSCLEROSIS, vol. 196, no. 2, pp. 786-794. https://doi.org/10.1016/j.atherosclerosis.2007.01.012

APA

Möhlenkamp, S., Schmermund, A., Lehmann, N., Roggenbuck, U., Dragano, N., Stang, A., Moebus, S., Beck, E-M., Schlüter, C., Sack, S., Meinertz, T., Taylor, A., Jöckel, K-H., Erbel, R., & Heinz Nixdorf Recall Study Investigators (2008). Subclinical coronary atherosclerosis and resting ECG abnormalities in an unselected general population. ATHEROSCLEROSIS, 196(2), 786-794. https://doi.org/10.1016/j.atherosclerosis.2007.01.012

Vancouver

Möhlenkamp S, Schmermund A, Lehmann N, Roggenbuck U, Dragano N, Stang A et al. Subclinical coronary atherosclerosis and resting ECG abnormalities in an unselected general population. ATHEROSCLEROSIS. 2008 Feb;196(2):786-794. https://doi.org/10.1016/j.atherosclerosis.2007.01.012

Bibtex

@article{8037aba1f06640c3824485d772f77fca,
title = "Subclinical coronary atherosclerosis and resting ECG abnormalities in an unselected general population",
abstract = "OBJECTIVES: Exposure to cardiovascular (CV) risk factors may result in coronary atherosclerosis and myocardial disease, which is reflected in the extent of coronary artery calcification (CAC) and resting ECG abnormalities, respectively. We studied the association of CAC with ECG abnormalities in a general population without myocardial infarction or revascularization.METHODS: The total cohort of 4814 subjects (45-75 years) were randomly selected from the general population for the Heinz Nixdorf Recall Study, an ongoing study designed to assess the prognostic value of modern risk stratification methods. In addition to measuring standard risk factors, digitized resting ECGs and the EBT-based Agatston score were obtained. Subjects were separated into those without (n=1929) and with CV disease (CVD) or treated risk factors (tRF) (n=2558).RESULTS: In both groups, a positive CAC-score was more frequent and CAC-scores were higher in men and women with ECG abnormalities as compared to those with normal ECGs (p<0.05 each). In persons without CVD/tRF, a CAC > or =75th percentile was more frequent in those with LVH (42.4%) and QTc >440 ms (34.2%) as compared to normal ECGs (23.0%, p<0.01 for both). In persons with CVD/tRF, a CAC-score > or =75th percentile was found in subjects with A-Fib (46.3%), borderline-LVH (39.1%), ECG signs of MI (40.5%) and major ECG abnormalities (40.3%) versus 31.2% in those with normal ECGs (p<0.03 for all). In multivariate analysis, LVH (p=0.025) and major ECG abnormalities (p=0.04) remained independently associated with CAC in subjects without and with CVD/tRF, respectively.CONCLUSIONS: ECG-based evidence of myocardial disease is often associated with an elevated CAC burden, suggesting a link between epicardial and myocardial manifestations of risk factor exposure. The association of CAC burden with different ECG abnormalities in different clinical groups may have implications for the interpretation of the resting ECG and CAC burden in risk stratification.",
keywords = "Aged, Calcinosis/diagnosis, Cohort Studies, Coronary Artery Disease/diagnosis, Electrocardiography, Female, Germany, Humans, Hypertrophy, Left Ventricular/etiology, Male, Middle Aged, Predictive Value of Tests, Risk Factors, Sensitivity and Specificity",
author = "Stefan M{\"o}hlenkamp and Axel Schmermund and Nils Lehmann and Ulla Roggenbuck and Nico Dragano and Andreas Stang and Susanne Moebus and Eva-Maria Beck and Christamaria Schl{\"u}ter and Stefan Sack and Thomas Meinertz and Allen Taylor and Karl-Heinz J{\"o}ckel and Raimund Erbel and {Heinz Nixdorf Recall Study Investigators}",
year = "2008",
month = feb,
doi = "10.1016/j.atherosclerosis.2007.01.012",
language = "English",
volume = "196",
pages = "786--794",
journal = "ATHEROSCLEROSIS",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Subclinical coronary atherosclerosis and resting ECG abnormalities in an unselected general population

AU - Möhlenkamp, Stefan

AU - Schmermund, Axel

AU - Lehmann, Nils

AU - Roggenbuck, Ulla

AU - Dragano, Nico

AU - Stang, Andreas

AU - Moebus, Susanne

AU - Beck, Eva-Maria

AU - Schlüter, Christamaria

AU - Sack, Stefan

AU - Meinertz, Thomas

AU - Taylor, Allen

AU - Jöckel, Karl-Heinz

AU - Erbel, Raimund

AU - Heinz Nixdorf Recall Study Investigators

PY - 2008/2

Y1 - 2008/2

N2 - OBJECTIVES: Exposure to cardiovascular (CV) risk factors may result in coronary atherosclerosis and myocardial disease, which is reflected in the extent of coronary artery calcification (CAC) and resting ECG abnormalities, respectively. We studied the association of CAC with ECG abnormalities in a general population without myocardial infarction or revascularization.METHODS: The total cohort of 4814 subjects (45-75 years) were randomly selected from the general population for the Heinz Nixdorf Recall Study, an ongoing study designed to assess the prognostic value of modern risk stratification methods. In addition to measuring standard risk factors, digitized resting ECGs and the EBT-based Agatston score were obtained. Subjects were separated into those without (n=1929) and with CV disease (CVD) or treated risk factors (tRF) (n=2558).RESULTS: In both groups, a positive CAC-score was more frequent and CAC-scores were higher in men and women with ECG abnormalities as compared to those with normal ECGs (p<0.05 each). In persons without CVD/tRF, a CAC > or =75th percentile was more frequent in those with LVH (42.4%) and QTc >440 ms (34.2%) as compared to normal ECGs (23.0%, p<0.01 for both). In persons with CVD/tRF, a CAC-score > or =75th percentile was found in subjects with A-Fib (46.3%), borderline-LVH (39.1%), ECG signs of MI (40.5%) and major ECG abnormalities (40.3%) versus 31.2% in those with normal ECGs (p<0.03 for all). In multivariate analysis, LVH (p=0.025) and major ECG abnormalities (p=0.04) remained independently associated with CAC in subjects without and with CVD/tRF, respectively.CONCLUSIONS: ECG-based evidence of myocardial disease is often associated with an elevated CAC burden, suggesting a link between epicardial and myocardial manifestations of risk factor exposure. The association of CAC burden with different ECG abnormalities in different clinical groups may have implications for the interpretation of the resting ECG and CAC burden in risk stratification.

AB - OBJECTIVES: Exposure to cardiovascular (CV) risk factors may result in coronary atherosclerosis and myocardial disease, which is reflected in the extent of coronary artery calcification (CAC) and resting ECG abnormalities, respectively. We studied the association of CAC with ECG abnormalities in a general population without myocardial infarction or revascularization.METHODS: The total cohort of 4814 subjects (45-75 years) were randomly selected from the general population for the Heinz Nixdorf Recall Study, an ongoing study designed to assess the prognostic value of modern risk stratification methods. In addition to measuring standard risk factors, digitized resting ECGs and the EBT-based Agatston score were obtained. Subjects were separated into those without (n=1929) and with CV disease (CVD) or treated risk factors (tRF) (n=2558).RESULTS: In both groups, a positive CAC-score was more frequent and CAC-scores were higher in men and women with ECG abnormalities as compared to those with normal ECGs (p<0.05 each). In persons without CVD/tRF, a CAC > or =75th percentile was more frequent in those with LVH (42.4%) and QTc >440 ms (34.2%) as compared to normal ECGs (23.0%, p<0.01 for both). In persons with CVD/tRF, a CAC-score > or =75th percentile was found in subjects with A-Fib (46.3%), borderline-LVH (39.1%), ECG signs of MI (40.5%) and major ECG abnormalities (40.3%) versus 31.2% in those with normal ECGs (p<0.03 for all). In multivariate analysis, LVH (p=0.025) and major ECG abnormalities (p=0.04) remained independently associated with CAC in subjects without and with CVD/tRF, respectively.CONCLUSIONS: ECG-based evidence of myocardial disease is often associated with an elevated CAC burden, suggesting a link between epicardial and myocardial manifestations of risk factor exposure. The association of CAC burden with different ECG abnormalities in different clinical groups may have implications for the interpretation of the resting ECG and CAC burden in risk stratification.

KW - Aged

KW - Calcinosis/diagnosis

KW - Cohort Studies

KW - Coronary Artery Disease/diagnosis

KW - Electrocardiography

KW - Female

KW - Germany

KW - Humans

KW - Hypertrophy, Left Ventricular/etiology

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Risk Factors

KW - Sensitivity and Specificity

U2 - 10.1016/j.atherosclerosis.2007.01.012

DO - 10.1016/j.atherosclerosis.2007.01.012

M3 - SCORING: Journal article

C2 - 17350632

VL - 196

SP - 786

EP - 794

JO - ATHEROSCLEROSIS

JF - ATHEROSCLEROSIS

SN - 0021-9150

IS - 2

ER -